Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H: quinone oxidoreductase 1 C609T polymorphism in human breast tissues

Ling Ming Tseng, Pen Hui Yin, Yi Fang Tsai, Chin Wen Chi, Chew Wun Wu, Liang Ming Lee, Hsin Chen Lee

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12 Citations (Scopus)

Abstract

The NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme is implicated in protection against oxidative stress and carcinogenesis. NQO1 C609T genetic polymorphism was reported to be associated with an increased risk for cancers, including breast cancer. However, there is still lack of evidence whether higher oxidative stress occurs in breast tissues of patients with NQO1 609 C/T and/or T/T genotypes. Mitochondrial DNA (MtDNA) 4,977-bp deletion, the most common mutation of mtDNA, was frequently detected in post-mitotic tissues of aged subjects and associated with oxidative damage. In this study, we detected the mtDNA 4,977-bp deletion in 60 breast cancers and corresponding non-cancerous breast tissues. The incidence of the common 4,977-bp deletion in non-cancerous breast tissues (48.3%) was higher than that in breast cancer (5.0%). Moreover, 63.4% of the breast cancer patients with NQO1 C/ T or T/T genotypes had the deletion in their non-cancerous breast tissues. The mtDNA deletion was more frequently detected in breast tissue of NQO1 C/T carriers (65.2%) and T/T carriers (61.1%) as compared with the NQO1 C/C carriers (15.8%, P=0.003). Similar results were observed in the

Original languageEnglish
Pages (from-to)1169-1174
Number of pages6
JournalOncology Reports
Volume21
Issue number5
DOIs
Publication statusPublished - 2009

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Keywords

  • Breast cancer
  • Mitochondrial DNA deletion
  • NAD(P)H:quinone oxidoreductase 1
  • Oxidative stress

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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