Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction

A cohort study of 10,612 women in Taiwan

Li Chung Chuang, Hui Chi Chen, San Lin You, Ching Yu Lin, Mei Hung Pan, Yi Chun Chou, Chang Yao Hsieh, Chien Jen Chen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This study aimed at assessing the association between the type-specific human papillomavirus (HPV) infection and the risk of adenocarcinoma of the rectum and recto-sigmoid junction. A total of 10,612 women aged 30-65 years old were enrolled from seven townships in Taiwan. Cervical cells collected at study entry were tested for 39 types of HPV infection by polymerase chain reactions and HPV blot kit. Newly developed adenocarcinomas of rectum and recto-sigmoid junction were ascertained through computerized linkage with national cancer registry profiles. An increased risk of adenocarcinomas of the rectum and recto-sigmoid junction was observed with HPV infection, showing a hazard ratio [HR] (95% confidence interval [CI]) of 1.99 (0.98-4.04) after adjustment for age and body mass index. The adjusted HR (95% CI) for the infection of HPV types other than 6 and 11 was 2.18 (1.04-4.60). Women with cervical infection of HPV types other than 6 and 11 at study entry may have an increased risk of adenocarcinomas of the rectum and recto-sigmoid junction, which deserves further validation by large-scale studies.

Original languageEnglish
Pages (from-to)2123-2128
Number of pages6
JournalCancer Causes and Control
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Fingerprint

Sigmoid Colon
Taiwan
Rectum
Papillomavirus Infections
Adenocarcinoma
Cohort Studies
Human papillomavirus 11
Human papillomavirus 6
Confidence Intervals
Infection
Registries
Body Mass Index
Polymerase Chain Reaction
Neoplasms

Keywords

  • Adenocarcinoma
  • Human papillomavirus
  • Rectum

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction : A cohort study of 10,612 women in Taiwan. / Chuang, Li Chung; Chen, Hui Chi; You, San Lin; Lin, Ching Yu; Pan, Mei Hung; Chou, Yi Chun; Hsieh, Chang Yao; Chen, Chien Jen.

In: Cancer Causes and Control, Vol. 21, No. 12, 12.2010, p. 2123-2128.

Research output: Contribution to journalArticle

Chuang, Li Chung ; Chen, Hui Chi ; You, San Lin ; Lin, Ching Yu ; Pan, Mei Hung ; Chou, Yi Chun ; Hsieh, Chang Yao ; Chen, Chien Jen. / Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction : A cohort study of 10,612 women in Taiwan. In: Cancer Causes and Control. 2010 ; Vol. 21, No. 12. pp. 2123-2128.
@article{e9798e1962c04f98bd1d0a10710855e9,
title = "Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction: A cohort study of 10,612 women in Taiwan",
abstract = "This study aimed at assessing the association between the type-specific human papillomavirus (HPV) infection and the risk of adenocarcinoma of the rectum and recto-sigmoid junction. A total of 10,612 women aged 30-65 years old were enrolled from seven townships in Taiwan. Cervical cells collected at study entry were tested for 39 types of HPV infection by polymerase chain reactions and HPV blot kit. Newly developed adenocarcinomas of rectum and recto-sigmoid junction were ascertained through computerized linkage with national cancer registry profiles. An increased risk of adenocarcinomas of the rectum and recto-sigmoid junction was observed with HPV infection, showing a hazard ratio [HR] (95{\%} confidence interval [CI]) of 1.99 (0.98-4.04) after adjustment for age and body mass index. The adjusted HR (95{\%} CI) for the infection of HPV types other than 6 and 11 was 2.18 (1.04-4.60). Women with cervical infection of HPV types other than 6 and 11 at study entry may have an increased risk of adenocarcinomas of the rectum and recto-sigmoid junction, which deserves further validation by large-scale studies.",
keywords = "Adenocarcinoma, Human papillomavirus, Rectum",
author = "Chuang, {Li Chung} and Chen, {Hui Chi} and You, {San Lin} and Lin, {Ching Yu} and Pan, {Mei Hung} and Chou, {Yi Chun} and Hsieh, {Chang Yao} and Chen, {Chien Jen}",
year = "2010",
month = "12",
doi = "10.1007/s10552-010-9631-5",
language = "English",
volume = "21",
pages = "2123--2128",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "12",

}

TY - JOUR

T1 - Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction

T2 - A cohort study of 10,612 women in Taiwan

AU - Chuang, Li Chung

AU - Chen, Hui Chi

AU - You, San Lin

AU - Lin, Ching Yu

AU - Pan, Mei Hung

AU - Chou, Yi Chun

AU - Hsieh, Chang Yao

AU - Chen, Chien Jen

PY - 2010/12

Y1 - 2010/12

N2 - This study aimed at assessing the association between the type-specific human papillomavirus (HPV) infection and the risk of adenocarcinoma of the rectum and recto-sigmoid junction. A total of 10,612 women aged 30-65 years old were enrolled from seven townships in Taiwan. Cervical cells collected at study entry were tested for 39 types of HPV infection by polymerase chain reactions and HPV blot kit. Newly developed adenocarcinomas of rectum and recto-sigmoid junction were ascertained through computerized linkage with national cancer registry profiles. An increased risk of adenocarcinomas of the rectum and recto-sigmoid junction was observed with HPV infection, showing a hazard ratio [HR] (95% confidence interval [CI]) of 1.99 (0.98-4.04) after adjustment for age and body mass index. The adjusted HR (95% CI) for the infection of HPV types other than 6 and 11 was 2.18 (1.04-4.60). Women with cervical infection of HPV types other than 6 and 11 at study entry may have an increased risk of adenocarcinomas of the rectum and recto-sigmoid junction, which deserves further validation by large-scale studies.

AB - This study aimed at assessing the association between the type-specific human papillomavirus (HPV) infection and the risk of adenocarcinoma of the rectum and recto-sigmoid junction. A total of 10,612 women aged 30-65 years old were enrolled from seven townships in Taiwan. Cervical cells collected at study entry were tested for 39 types of HPV infection by polymerase chain reactions and HPV blot kit. Newly developed adenocarcinomas of rectum and recto-sigmoid junction were ascertained through computerized linkage with national cancer registry profiles. An increased risk of adenocarcinomas of the rectum and recto-sigmoid junction was observed with HPV infection, showing a hazard ratio [HR] (95% confidence interval [CI]) of 1.99 (0.98-4.04) after adjustment for age and body mass index. The adjusted HR (95% CI) for the infection of HPV types other than 6 and 11 was 2.18 (1.04-4.60). Women with cervical infection of HPV types other than 6 and 11 at study entry may have an increased risk of adenocarcinomas of the rectum and recto-sigmoid junction, which deserves further validation by large-scale studies.

KW - Adenocarcinoma

KW - Human papillomavirus

KW - Rectum

UR - http://www.scopus.com/inward/record.url?scp=78751528793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751528793&partnerID=8YFLogxK

U2 - 10.1007/s10552-010-9631-5

DO - 10.1007/s10552-010-9631-5

M3 - Article

VL - 21

SP - 2123

EP - 2128

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 12

ER -