Association between Gastroesophageal Reflux Disease and Appendicitis

A Population-Based Case-Control Study

Li Ting Kao, Ming Chieh Tsai, Herng Ching Lin, Cha Ze Lee

Research output: Contribution to journalArticle

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Abstract

Appendicitis and gastroesophageal reflux disease (GERD) are both prevalent diseases and might share similar pathological mechanisms. The aim of this study was to investigate the association between GERD and appendicitis using a large population-based dataset. This study used administrative claims data from the Taiwan Longitudinal Health Insurance Database 2005. We identified 7113 patients with appendicitis as cases, and 28452 matched patients without appendicitis as controls. This study revealed that GERD was found in 359 (5.05%) cases and 728 (2.56%) controls (p <0.001). Conditional logistic regression shows that the adjusted odds ratio (OR) of GERD for cases was 2.05 (95% confidence interval (CI): 1.08∼2.33) compared to controls. The adjusted ORs of prior GERD for patients aged 18∼39, 40∼59, and ≥60 years with appendicitis were 1.96 (95% CI: 1.56∼2.47), 2.36 (95% CI: 1.94∼2.88), and 1.71 (95% CI: 1.31∼2.22) than controls, respectively. We concluded that patients with appendicitis had higher odds of prior GERD than those without appendicitis regardless of age group.

Original languageEnglish
Article number22430
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Mar 2 2016

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Appendicitis
Gastroesophageal Reflux
Case-Control Studies
Population
Confidence Intervals
Health Insurance
Taiwan
Age Groups
Logistic Models
Odds Ratio
Databases

ASJC Scopus subject areas

  • General

Cite this

Association between Gastroesophageal Reflux Disease and Appendicitis : A Population-Based Case-Control Study. / Kao, Li Ting; Tsai, Ming Chieh; Lin, Herng Ching; Lee, Cha Ze.

In: Scientific Reports, Vol. 6, 22430, 02.03.2016.

Research output: Contribution to journalArticle

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