Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population

Chun Chin Chang, Chien Yi Hsu, Po Hsun Huang, Li Kuo Liu, Liang-Kung Chen, Jaw Wen J.W. Chen, Shing Jong Lin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: Frailty is a highly prevalent geriatric syndrome, characterized by increased vulnerability to subsequent morbidity and mortality. The association between frailty and preclinical atherosclerosis remains uncertain. The aim of the present study was to clarify the relationship between frailty, preclinical atherosclerosis and inflammatory markers in older adults. Methods: We enrolled 1798 inhabitants of I-Lan County of Taiwan (855 men, 47.5%; mean age 64 ± 9 years, range 50–92 years). Assessment of frailty was based on the Cardiovascular Health Study criteria. Common carotid artery intima-media thickness (CIMT) was determined using carotid Doppler ultrasonography. Results: Overall, 955 participants (53.1%) were non-frail, 724 (40.2%) were pre-frail and 119 (6.7%) were frail. Frail and pre-frail participants had significantly increased CIMT, high-sensitivity C-reactive protein, glycated hemoglobin and urine albumin-to-creatinine ratio, but had lower insulin-like growth factor-1 level and decreased femoral neck bone mineral density (BMD). By multivariate analysis, age (OR 2.53, 95% CI 1.92–3.33), C-reactive protein (OR 1.19, 95% CI 1.00–1.42), CIMT (OR 1.27, 95% CI 1.04–1.55) and femoral neck BMD (OR 0.49, 95% CI 0.38–0.65) were independently associated with frailty. Conclusions: The present study showed the epidemiology of frailty, and the strong connection to aging, increased CIMT, enhanced inflammation and decreased femoral neck BMD. These results suggested that preclinical atherosclerosis, inflammation and femoral neck BMD were potentially modifiable risk factors for frailty. Geriatr Gerontol Int 2017; 17: 2449–2454. © 2017 Japan Geriatrics Society
Original languageEnglish
Pages (from-to)2449-2454
Number of pages6
JournalGeriatrics and Gerontology International
Volume17
Issue number12
DOIs
Publication statusPublished - 2017

Fingerprint

Carotid Intima-Media Thickness
Femur Neck
Bone Density
Carotid Arteries
Atherosclerosis
geriatrics
Geriatrics
C-Reactive Protein
Population
Inflammation
Doppler Ultrasonography
Common Carotid Artery
Glycosylated Hemoglobin A
Somatomedins
epidemiology
Taiwan
multivariate analysis
morbidity
inhabitant
Albumins

Keywords

  • atherosclerosis
  • frailty
  • inflammation
  • albumin
  • biological marker
  • C reactive protein
  • creatinine
  • glycosylated hemoglobin
  • somatomedin C
  • adult
  • aged
  • arterial wall thickness
  • Article
  • bone density
  • controlled study
  • cross-sectional study
  • disease association
  • Doppler ultrasonography
  • elderly care
  • female
  • femoral neck
  • human
  • major clinical study
  • male
  • priority journal
  • Taiwan
  • urinary excretion
  • frail elderly
  • middle aged
  • risk factor
  • very elderly
  • Aged
  • Aged, 80 and over
  • Atherosclerosis
  • Biomarkers
  • Bone Density
  • C-Reactive Protein
  • Carotid Intima-Media Thickness
  • Frail Elderly
  • Frailty
  • Humans
  • Inflammation
  • Male
  • Middle Aged
  • Risk Factors

Cite this

Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population. / Chang, Chun Chin; Hsu, Chien Yi; Huang, Po Hsun; Liu, Li Kuo; Chen, Liang-Kung; Chen, Jaw Wen J.W.; Lin, Shing Jong.

In: Geriatrics and Gerontology International, Vol. 17, No. 12, 2017, p. 2449-2454.

Research output: Contribution to journalArticle

Chang, Chun Chin ; Hsu, Chien Yi ; Huang, Po Hsun ; Liu, Li Kuo ; Chen, Liang-Kung ; Chen, Jaw Wen J.W. ; Lin, Shing Jong. / Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population. In: Geriatrics and Gerontology International. 2017 ; Vol. 17, No. 12. pp. 2449-2454.
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abstract = "Aim: Frailty is a highly prevalent geriatric syndrome, characterized by increased vulnerability to subsequent morbidity and mortality. The association between frailty and preclinical atherosclerosis remains uncertain. The aim of the present study was to clarify the relationship between frailty, preclinical atherosclerosis and inflammatory markers in older adults. Methods: We enrolled 1798 inhabitants of I-Lan County of Taiwan (855 men, 47.5{\%}; mean age 64 ± 9 years, range 50–92 years). Assessment of frailty was based on the Cardiovascular Health Study criteria. Common carotid artery intima-media thickness (CIMT) was determined using carotid Doppler ultrasonography. Results: Overall, 955 participants (53.1{\%}) were non-frail, 724 (40.2{\%}) were pre-frail and 119 (6.7{\%}) were frail. Frail and pre-frail participants had significantly increased CIMT, high-sensitivity C-reactive protein, glycated hemoglobin and urine albumin-to-creatinine ratio, but had lower insulin-like growth factor-1 level and decreased femoral neck bone mineral density (BMD). By multivariate analysis, age (OR 2.53, 95{\%} CI 1.92–3.33), C-reactive protein (OR 1.19, 95{\%} CI 1.00–1.42), CIMT (OR 1.27, 95{\%} CI 1.04–1.55) and femoral neck BMD (OR 0.49, 95{\%} CI 0.38–0.65) were independently associated with frailty. Conclusions: The present study showed the epidemiology of frailty, and the strong connection to aging, increased CIMT, enhanced inflammation and decreased femoral neck BMD. These results suggested that preclinical atherosclerosis, inflammation and femoral neck BMD were potentially modifiable risk factors for frailty. Geriatr Gerontol Int 2017; 17: 2449–2454. {\circledC} 2017 Japan Geriatrics Society",
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T1 - Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population

AU - Chang, Chun Chin

AU - Hsu, Chien Yi

AU - Huang, Po Hsun

AU - Liu, Li Kuo

AU - Chen, Liang-Kung

AU - Chen, Jaw Wen J.W.

AU - Lin, Shing Jong

N1 - 引用次數:1 Export Date: 18 September 2018 通訊地址: Chen, L.-K.; Center for Geriatrics and Gerontology, Taipei Veterans General HospitalTaiwan; 電子郵件: lkchen2@vghtpe.gov.tw

PY - 2017

Y1 - 2017

N2 - Aim: Frailty is a highly prevalent geriatric syndrome, characterized by increased vulnerability to subsequent morbidity and mortality. The association between frailty and preclinical atherosclerosis remains uncertain. The aim of the present study was to clarify the relationship between frailty, preclinical atherosclerosis and inflammatory markers in older adults. Methods: We enrolled 1798 inhabitants of I-Lan County of Taiwan (855 men, 47.5%; mean age 64 ± 9 years, range 50–92 years). Assessment of frailty was based on the Cardiovascular Health Study criteria. Common carotid artery intima-media thickness (CIMT) was determined using carotid Doppler ultrasonography. Results: Overall, 955 participants (53.1%) were non-frail, 724 (40.2%) were pre-frail and 119 (6.7%) were frail. Frail and pre-frail participants had significantly increased CIMT, high-sensitivity C-reactive protein, glycated hemoglobin and urine albumin-to-creatinine ratio, but had lower insulin-like growth factor-1 level and decreased femoral neck bone mineral density (BMD). By multivariate analysis, age (OR 2.53, 95% CI 1.92–3.33), C-reactive protein (OR 1.19, 95% CI 1.00–1.42), CIMT (OR 1.27, 95% CI 1.04–1.55) and femoral neck BMD (OR 0.49, 95% CI 0.38–0.65) were independently associated with frailty. Conclusions: The present study showed the epidemiology of frailty, and the strong connection to aging, increased CIMT, enhanced inflammation and decreased femoral neck BMD. These results suggested that preclinical atherosclerosis, inflammation and femoral neck BMD were potentially modifiable risk factors for frailty. Geriatr Gerontol Int 2017; 17: 2449–2454. © 2017 Japan Geriatrics Society

AB - Aim: Frailty is a highly prevalent geriatric syndrome, characterized by increased vulnerability to subsequent morbidity and mortality. The association between frailty and preclinical atherosclerosis remains uncertain. The aim of the present study was to clarify the relationship between frailty, preclinical atherosclerosis and inflammatory markers in older adults. Methods: We enrolled 1798 inhabitants of I-Lan County of Taiwan (855 men, 47.5%; mean age 64 ± 9 years, range 50–92 years). Assessment of frailty was based on the Cardiovascular Health Study criteria. Common carotid artery intima-media thickness (CIMT) was determined using carotid Doppler ultrasonography. Results: Overall, 955 participants (53.1%) were non-frail, 724 (40.2%) were pre-frail and 119 (6.7%) were frail. Frail and pre-frail participants had significantly increased CIMT, high-sensitivity C-reactive protein, glycated hemoglobin and urine albumin-to-creatinine ratio, but had lower insulin-like growth factor-1 level and decreased femoral neck bone mineral density (BMD). By multivariate analysis, age (OR 2.53, 95% CI 1.92–3.33), C-reactive protein (OR 1.19, 95% CI 1.00–1.42), CIMT (OR 1.27, 95% CI 1.04–1.55) and femoral neck BMD (OR 0.49, 95% CI 0.38–0.65) were independently associated with frailty. Conclusions: The present study showed the epidemiology of frailty, and the strong connection to aging, increased CIMT, enhanced inflammation and decreased femoral neck BMD. These results suggested that preclinical atherosclerosis, inflammation and femoral neck BMD were potentially modifiable risk factors for frailty. Geriatr Gerontol Int 2017; 17: 2449–2454. © 2017 Japan Geriatrics Society

KW - atherosclerosis

KW - frailty

KW - inflammation

KW - albumin

KW - biological marker

KW - C reactive protein

KW - creatinine

KW - glycosylated hemoglobin

KW - somatomedin C

KW - adult

KW - aged

KW - arterial wall thickness

KW - Article

KW - bone density

KW - controlled study

KW - cross-sectional study

KW - disease association

KW - Doppler ultrasonography

KW - elderly care

KW - female

KW - femoral neck

KW - human

KW - major clinical study

KW - male

KW - priority journal

KW - Taiwan

KW - urinary excretion

KW - frail elderly

KW - middle aged

KW - risk factor

KW - very elderly

KW - Aged

KW - Aged, 80 and over

KW - Atherosclerosis

KW - Biomarkers

KW - Bone Density

KW - C-Reactive Protein

KW - Carotid Intima-Media Thickness

KW - Frail Elderly

KW - Frailty

KW - Humans

KW - Inflammation

KW - Male

KW - Middle Aged

KW - Risk Factors

U2 - 10.1111/ggi.13099

DO - 10.1111/ggi.13099

M3 - Article

VL - 17

SP - 2449

EP - 2454

JO - Geriatrics and Gerontology International

JF - Geriatrics and Gerontology International

SN - 1447-0594

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