Association between emphysema score, six-minute walk and cardiopulmonary exercise tests in COPD

Li Fei Chen, Chun Hua Wang, Pai Chien Chou, Shu Chuan Ho, Wen Ching Joa, Te Fang Sheng, Han Pin Kuo

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background: High-resolution computed tomography (HRCT) has allowed in detection of airway wall abnormalities and emphysema, whose extent may correlate with the clinical severity of the disease in patients with chronic obstructive pulmonary disease (COPD). Six minute walk test (6MWT) and cardiopulmonary exercise test (CPET) can determine functional status. Methods: A study was undertaken to investigate whether the extent of emphysema in COPD patients quantitatively confirmed by HRCT scoring was associated with distance walked, inspiratory capacity (IC) changes after exercise, anaerobic threshold of cardiopulmonary exercise and the BODE index (body mass index, airflow obstruction, dyspnea, exercise performance). Results: Seventeen patients with COPD underwent HRCT scanning, 6MWT and CPET. The emphysema score was highly correlated to forced vital capacity (FVC) (r=-0.748, p2 max (r=-0.514, p

Original languageEnglish
Pages (from-to)104-110
Number of pages7
JournalOpen Respiratory Medicine Journal
Issue number1
Publication statusPublished - 2012
Externally publishedYes


  • Cardiopulmonary exercise test
  • Chronic obstructive pulmonary disease
  • High-resolution computed tomography
  • Inspiratory capacity
  • Six-minute walk test

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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