Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris

Ting Yung Chang, Chien Yi Hsu, Chun Chih Chiu, Ruey Hsing Chou, Hsin Lei Huang, Chin Chou Huang, Hsin Ban Leu, Po Hsun Huang, Jaw Wen Chen, Shing Jong Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Epicardial adipose tissue is associated with coronary artery disease (CAD). Circulating endothelial progenitor cell (EPC) level represents a marker of endothelial dysfunction and vascular health. However, the relationship between epicardial fat and circulating EPC remains unknown. This study aimed to investigate association between echocardiographic epicardial fat thickness (EFT) and circulating EPC level. Hypothesis: Epicardial fat causes inflammation and contributes to progression of CAD. Methods: We enrolled 213 consecutive patients with stable angina, and EFT was determined by echocardiography. Quantification of EPC markers (defined as CD34 +, CD34 + KDR +, CD34 + KDR + CD133 + cells) in peripheral blood samples was used to measure circulating EPCs. All patients were divided into 3 tertiles according to EFT levels: group 1, low tertile of EFT; group 2, middle tertile of EFT; and group 3, high tertile of EFT. Results: Among the 3 groups, CAD disease severity determined by SXscore was negatively correlated with EFT, but the difference did not reach statistical significance (P = 0.066). Additionally, patients in the high and middle tertiles of EFT had higher circulating EPC levels than did those in the low tertile of EFT (P = 0.001 and P < 0.001, respectively). In multivariate analysis, EPC level was significantly associated with echocardiographic EFT (standardized β = −0.233, P = 0.001), independent of multiple covariates. Conclusions: Epicardial adipose tissue is associated with circulating EPC levels. There was a trend between epicardial fat and severity of CAD, though analysis did not reach statistical significance, and this may be attributed to the interaction between several risk factors of CAD.

Original languageEnglish
Pages (from-to)697-703
Number of pages7
JournalClinical Cardiology
Volume40
Issue number9
DOIs
Publication statusPublished - Sep 1 2017

Keywords

  • Atherosclerosis
  • Endothelial Progenitor Cell
  • Epicardial Fat

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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