Association between dietary patterns and serum hepatic enzyme levels in adults with dyslipidemia and impaired fasting plasma glucose

Li Yin Lin, Chien Yeh Hsu, Hung Yi Chiou, Hsiu An Lee, Li Ming Hsu, Po Ya Chang, Adi Lukas Kurniawan, Jane C.J. Chao

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the association between dietary patterns and serum hepatic enzyme levels in adults with dyslipidemia and impaired fasting glucose in Taiwan. A total of 15,005 subjects (5452 men and 9553 women) aged 35–69 years were selected. Two major dietary patterns were identified by principal component analysis: Western dietary pattern and Mediterranean dietary pattern. Subjects in the highest quartile (Q4) of the Western dietary pattern showed an increased risk of elevated serum alanine aminotransferase (ALT) levels (OR: 1.24, 95% CI: 1.06–1.45, p‐trend = 0.01). Fur‐thermore, in the highest quartile of the Western dietary pattern, subjects with high waist circum‐ference were observed to have a greater risk for developing abnormal serum ALT levels compared to those in the lowest quartile (Q1) (OR: 1.43, 95% CI: 1.04–1.97, p‐trend = 0.01). In the highest quartile of the Western dietary pattern, only women were at an increased risk for having abnormal serum ALT levels (OR: 1.28, 95% CI: 1.04–1.59, p‐trend = 0.03). By contrast, in the highest quartile of the Mediterranean dietary pattern, only men were at a reduced risk for having abnormal serum gamma‐glutamyl transferase (GGT) levels (OR: 0.72, 95% CI: 0.53–0.97, p‐trend = 0.048). We report a positive association between the Western dietary pattern and abnormal serum ALT levels.

Original languageEnglish
Article number987
Pages (from-to)1-17
Number of pages17
JournalNutrients
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Cross‐sectional study
  • Dietary patterns
  • Dyslipidemia
  • Factor analysis
  • Impaired fasting plasma glucose
  • Serum hepatic enzyme
  • Taiwan

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Association between dietary patterns and serum hepatic enzyme levels in adults with dyslipidemia and impaired fasting plasma glucose'. Together they form a unique fingerprint.

Cite this