Association between chronic hepatitis C virus infection and bone mineral density

Jung-Chun Lin, Tsai-Yuan Hsieh, Chia-Chun Wu, Peng-Jen Chen, Tung-Hung Chueh, Wei-Kuo Chang, Heng-Cheng Chu

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Whether chronic hepatitis C virus (HCV) infection is a risk factor for the development of bone disease has long been controversial. For this reason, chronic HCV-infected participants (n = 69) were recruited into a prospective cohort study and underwent dual-energy X-ray absorptiometry for determination of bone mineral density (BMD). Fibrosis staging was evaluated according to the noninvasive index FIB-4. T scores at the femoral neck and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease and BMD. The study cohort was 41 % male with a mean age of 53.6 years. The mean BMD, Z score, and T score values of lumbar spine in chronic hepatitis C (CHC) patients were significantly lower than those in healthy controls (p
Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalCalcified Tissue International
Volume91
Issue number6
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Bone mineral density
  • Osteodystrophy
  • Osteoporosis
  • Viral hepatitis
  • alkaline phosphatase bone isoenzyme
  • carboxy terminal telopeptide
  • adult
  • article
  • body composition
  • bone density
  • disease association
  • disease severity
  • dual energy X ray absorptiometry
  • female
  • femur neck
  • hepatitis C
  • human
  • liver fibrosis
  • lumbar spine
  • major clinical study
  • male
  • osteoporosis
  • premenopause
  • priority journal
  • scoring system
  • Absorptiometry, Photon
  • Bone Density
  • Bone Diseases, Metabolic
  • Case-Control Studies
  • Female
  • Hepatitis C, Chronic
  • Humans
  • Liver Cirrhosis
  • Male
  • Middle Aged
  • Premenopause

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  • Cite this

    Lin, J-C., Hsieh, T-Y., Wu, C-C., Chen, P-J., Chueh, T-H., Chang, W-K., & Chu, H-C. (2012). Association between chronic hepatitis C virus infection and bone mineral density. Calcified Tissue International, 91(6), 423-429. https://doi.org/10.1007/s00223-012-9653-y