Association between chronic hepatitis C virus infection and bone mineral density

Jung-Chun Lin, Tsai-Yuan Hsieh, Chia-Chun Wu, Peng-Jen Chen, Tung-Hung Chueh, Wei-Kuo Chang, Heng-Cheng Chu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Whether chronic hepatitis C virus (HCV) infection is a risk factor for the development of bone disease has long been controversial. For this reason, chronic HCV-infected participants (n = 69) were recruited into a prospective cohort study and underwent dual-energy X-ray absorptiometry for determination of bone mineral density (BMD). Fibrosis staging was evaluated according to the noninvasive index FIB-4. T scores at the femoral neck and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease and BMD. The study cohort was 41 % male with a mean age of 53.6 years. The mean BMD, Z score, and T score values of lumbar spine in chronic hepatitis C (CHC) patients were significantly lower than those in healthy controls (p
Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalCalcified Tissue International
Volume91
Issue number6
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Chronic Hepatitis C
Virus Diseases
Hepacivirus
Bone Density
Spine
Cohort Studies
Bone Diseases
Femur Neck
Photon Absorptiometry
Liver Diseases
Fibrosis
Prospective Studies

Keywords

  • Bone mineral density
  • Osteodystrophy
  • Osteoporosis
  • Viral hepatitis
  • alkaline phosphatase bone isoenzyme
  • carboxy terminal telopeptide
  • adult
  • article
  • body composition
  • bone density
  • disease association
  • disease severity
  • dual energy X ray absorptiometry
  • female
  • femur neck
  • hepatitis C
  • human
  • liver fibrosis
  • lumbar spine
  • major clinical study
  • male
  • osteoporosis
  • premenopause
  • priority journal
  • scoring system
  • Absorptiometry, Photon
  • Bone Density
  • Bone Diseases, Metabolic
  • Case-Control Studies
  • Female
  • Hepatitis C, Chronic
  • Humans
  • Liver Cirrhosis
  • Male
  • Middle Aged
  • Premenopause

Cite this

Association between chronic hepatitis C virus infection and bone mineral density. / Lin, Jung-Chun; Hsieh, Tsai-Yuan; Wu, Chia-Chun; Chen, Peng-Jen; Chueh, Tung-Hung; Chang, Wei-Kuo; Chu, Heng-Cheng.

In: Calcified Tissue International, Vol. 91, No. 6, 2012, p. 423-429.

Research output: Contribution to journalArticle

Lin, Jung-Chun ; Hsieh, Tsai-Yuan ; Wu, Chia-Chun ; Chen, Peng-Jen ; Chueh, Tung-Hung ; Chang, Wei-Kuo ; Chu, Heng-Cheng. / Association between chronic hepatitis C virus infection and bone mineral density. In: Calcified Tissue International. 2012 ; Vol. 91, No. 6. pp. 423-429.
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abstract = "Whether chronic hepatitis C virus (HCV) infection is a risk factor for the development of bone disease has long been controversial. For this reason, chronic HCV-infected participants (n = 69) were recruited into a prospective cohort study and underwent dual-energy X-ray absorptiometry for determination of bone mineral density (BMD). Fibrosis staging was evaluated according to the noninvasive index FIB-4. T scores at the femoral neck and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease and BMD. The study cohort was 41 {\%} male with a mean age of 53.6 years. The mean BMD, Z score, and T score values of lumbar spine in chronic hepatitis C (CHC) patients were significantly lower than those in healthy controls (p",
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author = "Jung-Chun Lin and Tsai-Yuan Hsieh and Chia-Chun Wu and Peng-Jen Chen and Tung-Hung Chueh and Wei-Kuo Chang and Heng-Cheng Chu",
note = "被引用次數:10 Export Date: 22 March 2016 CODEN: CTIND 通訊地址: Chu, H.-C.; Division of Gastroenterology, Tri-Service General Hospital, National Defense Medical Center, Cheng-Kung Road, Taipei, Taiwan; 電子郵件: doc10272@yahoo.com 參考文獻: Raisz, L.G., Clinical practice. Screening for osteoporosis (2005) N Engl J Med, 353, pp. 164-171; Bone disorders in chronic liver disease (2007) Hepatology, 46, pp. 1271-1278. , Collier J; Hay, J.E., Guichelaar, M.M., Evaluation and management of osteoporosis in liver disease (2005) Clin Liver Dis, 9, pp. 747-766; Leslie, W.D., Bernstein, C.N., Leboff, M.S., Aga technical review on osteoporosis in hepatic disorders (2003) Gastroenterology, 125, pp. 941-966; Monegal, A., Navasa, M., Guanabens, N., Peris, P., Pons, F., Martinez De Osaba, M.J., Rimola, A., Munoz-Gomez, J., Osteoporosis and bone mineral metabolism disorders in cirrhotic patients referred for orthotopic liver transplantation (1997) Calcif Tissue Int, 60, pp. 148-154; Crosbie, O.M., Freaney, R., McKenna, M.J., Hegarty, J.E., Bone density, vitamin d status, and disordered bone remodeling in endstage chronic liver disease (1999) Calcif Tissue Int, 64, pp. 295-300; Bagur, A., Mautalen, C., Findor, J., Sorda, J., Somoza, J., Risk factors for the development of vertebral and total skeleton osteoporosis in patients with primary biliary cirrhosis (1998) Calcif Tissue Int, 63, pp. 385-390; Guidelines on the management of osteoporosis associated with chronic liver disease (2002) Gut, 50 (SUPPL. 1), pp. i1-i9. , Collier JD, Ninkovic M, Compston JE; Global surveillance and control of hepatitis c (1999) J Viral Hepat, 6, pp. 35-47. , WHO, Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium; Yucel, A.E., Kart-Koseoglu, H., Isiklar, I., Kuruinci, E., Ozdemir, F.N., Arslan, H., Bone mineral density in patients on maintenance hemodialysis and effect of chronic hepatitis c virus infection (2004) Ren Fail, 26, pp. 159-164; Luchi, S., Fiorini, I., Meini, M., Scasso, A., Alterations of bone metabolism in patients with chronic c virus hepatitis [in italian] (2005) Infez Med, 13, pp. 23-27; Schiefke, I., Fach, A., Wiedmann, M., Aretin, A.V., Schenker, E., Borte, G., Wiese, M., Moessner, J., Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis b or c infection (2005) World J Gastroenterol, 11, pp. 1843-1847; Yenice, N., Gumrah, M., Mehtap, O., Kozan, A., Turkmen, S., Assessment of bone metabolism and mineral density in chronic viral hepatitis (2006) Turk J Gastroenterol, 17, pp. 260-266; Lo Re III, V., Guaraldi, G., Leonard, M.B., Localio, A.R., Lin, J., Orlando, G., Zirilli, L., Tebas, P., Viral hepatitis is associated with reduced bone mineral density in hiv-infected women but not men (2009) AIDS, 23, pp. 2191-2198; Nanda, K.S., Ryan, E.J., Murray, B.F., Brady, J.J., McKenna, M.J., Nolan, N., O'Farrelly, C., Hegarty, J.E., Effect of chronic hepatitis c virus infection on bone disease in postmenopausal women (2009) Clin Gastroenterol Hepatol, 7, pp. 894-899; El-Maouche, D., Mehta, S.H., Sutcliffe, C., Higgins, Y., Torbenson, M.S., Moore, R.D., Thomas, D.L., Brown, T.T., Controlled hiv viral replication, not liver disease severity associated with low bone mineral density in hiv/hcv co-infection (2011) J Hepatol, 55, pp. 770-776; Wiegard, C., Schramm, C., Lohse, A.W., Scoring systems for the diagnosis of autoimmune hepatitis: Past, present, and future (2009) Semin Liver Dis, 29, pp. 254-261; Garnero, P., Sornay-Rendu, E., Claustrat, B., Delmas, P.D., Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The ofely study (2000) J Bone Miner Res, 15, pp. 1526-1536; Garnero, P., Gineyts, E., Riou, J.P., Delmas, P.D., Assessment of bone resorption with a new marker of collagen degradation in patients with metabolic bone disease (1994) J Clin Endocrinol Metab, 79, pp. 780-785; Vallet-Pichard, A., Mallet, V., Nalpas, B., Verkarre, V., Nalpas, A., Dhalluin-Venier, V., Fontaine, H., Pol, S., Fib-4: An inexpensive and accurate marker of fibrosis in hcv infection. Comparison with liver biopsy and fibrotest (2007) Hepatology, 46, pp. 32-36; LaForgia, J., Dollman, J., Dale, M.J., Withers, R.T., Hill, A.M., Validation of dxa body composition estimates in obese men and women (2009) Obesity (Silver Spring, 17, pp. 821-826; Bredella, M.A., Ghomi, R.H., Thomas, B.J., Torriani, M., Brick, D.J., Gerweck, A.V., Misra, M., Miller, K.K., Comparison of dxa and ct in the assessment of body composition in premenopausal women with obesity and anorexia nervosa (2010) Obesity (Silver Spring, 18, pp. 2227-2233; Huang, G.S., Chu, T.S., Lou, M.F., Hwang, S.L., Yang, R.S., Factors associated with low bone mass in the hemodialysis patients -A cross-sectional correlation study (2009) BMC Musculoskelet Disord, 10, p. 60; Mauck, K.F., Clarke, B.L., Diagnosis, screening, prevention, and treatment of osteoporosis (2006) Mayo Clin Proc, 81, pp. 662-672; McCaughan, G.W., Feller, R.B., Osteoporosis in chronic liver disease: Pathogenesis, risk factors, and management (1994) Dig Dis, 12, pp. 223-231; Rouillard, S., Lane, N.E., Hepatic osteodystrophy (2001) Hepatology, 33, pp. 301-307; Hsu, S.H., Tsai, K.S., Different age-related trends of bone and nonbone forms of alkaline phosphatase in chinese men and women (1997) Clin Chem, 43, pp. 186-188; Iki, M., Kajita, E., Dohi, Y., Nishino, H., Kusaka, Y., Tsuchida, C., Yamamoto, K., Ishii, Y., Age, menopause, bone turnover markers and lumbar bone loss in healthy japanese women (1996) Maturitas, 25, pp. 59-67; Melton III, L.J., Khosla, S., Atkinson, E.J., O'Fallon, W.M., Riggs, B.L., Relationship of bone turnover to bone density and fractures (1997) J Bone Miner Res, 12, pp. 1083-1091; Tsai, K.S., Pan, W.H., Hsu, S.H., Cheng, W.C., Chen, C.K., Chieng, P.U., Yang, R.S., Twu, S.T., Sexual differences in bone markers and bone mineral density of normal chinese (1996) Calcif Tissue Int, 59, pp. 454-460",
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language = "English",
volume = "91",
pages = "423--429",
journal = "Calcified Tissue International",
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}

TY - JOUR

T1 - Association between chronic hepatitis C virus infection and bone mineral density

AU - Lin, Jung-Chun

AU - Hsieh, Tsai-Yuan

AU - Wu, Chia-Chun

AU - Chen, Peng-Jen

AU - Chueh, Tung-Hung

AU - Chang, Wei-Kuo

AU - Chu, Heng-Cheng

N1 - 被引用次數:10 Export Date: 22 March 2016 CODEN: CTIND 通訊地址: Chu, H.-C.; Division of Gastroenterology, Tri-Service General Hospital, National Defense Medical Center, Cheng-Kung Road, Taipei, Taiwan; 電子郵件: doc10272@yahoo.com 參考文獻: Raisz, L.G., Clinical practice. Screening for osteoporosis (2005) N Engl J Med, 353, pp. 164-171; Bone disorders in chronic liver disease (2007) Hepatology, 46, pp. 1271-1278. , Collier J; Hay, J.E., Guichelaar, M.M., Evaluation and management of osteoporosis in liver disease (2005) Clin Liver Dis, 9, pp. 747-766; Leslie, W.D., Bernstein, C.N., Leboff, M.S., Aga technical review on osteoporosis in hepatic disorders (2003) Gastroenterology, 125, pp. 941-966; Monegal, A., Navasa, M., Guanabens, N., Peris, P., Pons, F., Martinez De Osaba, M.J., Rimola, A., Munoz-Gomez, J., Osteoporosis and bone mineral metabolism disorders in cirrhotic patients referred for orthotopic liver transplantation (1997) Calcif Tissue Int, 60, pp. 148-154; Crosbie, O.M., Freaney, R., McKenna, M.J., Hegarty, J.E., Bone density, vitamin d status, and disordered bone remodeling in endstage chronic liver disease (1999) Calcif Tissue Int, 64, pp. 295-300; Bagur, A., Mautalen, C., Findor, J., Sorda, J., Somoza, J., Risk factors for the development of vertebral and total skeleton osteoporosis in patients with primary biliary cirrhosis (1998) Calcif Tissue Int, 63, pp. 385-390; Guidelines on the management of osteoporosis associated with chronic liver disease (2002) Gut, 50 (SUPPL. 1), pp. i1-i9. , Collier JD, Ninkovic M, Compston JE; Global surveillance and control of hepatitis c (1999) J Viral Hepat, 6, pp. 35-47. , WHO, Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium; Yucel, A.E., Kart-Koseoglu, H., Isiklar, I., Kuruinci, E., Ozdemir, F.N., Arslan, H., Bone mineral density in patients on maintenance hemodialysis and effect of chronic hepatitis c virus infection (2004) Ren Fail, 26, pp. 159-164; Luchi, S., Fiorini, I., Meini, M., Scasso, A., Alterations of bone metabolism in patients with chronic c virus hepatitis [in italian] (2005) Infez Med, 13, pp. 23-27; Schiefke, I., Fach, A., Wiedmann, M., Aretin, A.V., Schenker, E., Borte, G., Wiese, M., Moessner, J., Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis b or c infection (2005) World J Gastroenterol, 11, pp. 1843-1847; Yenice, N., Gumrah, M., Mehtap, O., Kozan, A., Turkmen, S., Assessment of bone metabolism and mineral density in chronic viral hepatitis (2006) Turk J Gastroenterol, 17, pp. 260-266; Lo Re III, V., Guaraldi, G., Leonard, M.B., Localio, A.R., Lin, J., Orlando, G., Zirilli, L., Tebas, P., Viral hepatitis is associated with reduced bone mineral density in hiv-infected women but not men (2009) AIDS, 23, pp. 2191-2198; Nanda, K.S., Ryan, E.J., Murray, B.F., Brady, J.J., McKenna, M.J., Nolan, N., O'Farrelly, C., Hegarty, J.E., Effect of chronic hepatitis c virus infection on bone disease in postmenopausal women (2009) Clin Gastroenterol Hepatol, 7, pp. 894-899; El-Maouche, D., Mehta, S.H., Sutcliffe, C., Higgins, Y., Torbenson, M.S., Moore, R.D., Thomas, D.L., Brown, T.T., Controlled hiv viral replication, not liver disease severity associated with low bone mineral density in hiv/hcv co-infection (2011) J Hepatol, 55, pp. 770-776; Wiegard, C., Schramm, C., Lohse, A.W., Scoring systems for the diagnosis of autoimmune hepatitis: Past, present, and future (2009) Semin Liver Dis, 29, pp. 254-261; Garnero, P., Sornay-Rendu, E., Claustrat, B., Delmas, P.D., Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The ofely study (2000) J Bone Miner Res, 15, pp. 1526-1536; Garnero, P., Gineyts, E., Riou, J.P., Delmas, P.D., Assessment of bone resorption with a new marker of collagen degradation in patients with metabolic bone disease (1994) J Clin Endocrinol Metab, 79, pp. 780-785; Vallet-Pichard, A., Mallet, V., Nalpas, B., Verkarre, V., Nalpas, A., Dhalluin-Venier, V., Fontaine, H., Pol, S., Fib-4: An inexpensive and accurate marker of fibrosis in hcv infection. Comparison with liver biopsy and fibrotest (2007) Hepatology, 46, pp. 32-36; LaForgia, J., Dollman, J., Dale, M.J., Withers, R.T., Hill, A.M., Validation of dxa body composition estimates in obese men and women (2009) Obesity (Silver Spring, 17, pp. 821-826; Bredella, M.A., Ghomi, R.H., Thomas, B.J., Torriani, M., Brick, D.J., Gerweck, A.V., Misra, M., Miller, K.K., Comparison of dxa and ct in the assessment of body composition in premenopausal women with obesity and anorexia nervosa (2010) Obesity (Silver Spring, 18, pp. 2227-2233; Huang, G.S., Chu, T.S., Lou, M.F., Hwang, S.L., Yang, R.S., Factors associated with low bone mass in the hemodialysis patients -A cross-sectional correlation study (2009) BMC Musculoskelet Disord, 10, p. 60; Mauck, K.F., Clarke, B.L., Diagnosis, screening, prevention, and treatment of osteoporosis (2006) Mayo Clin Proc, 81, pp. 662-672; McCaughan, G.W., Feller, R.B., Osteoporosis in chronic liver disease: Pathogenesis, risk factors, and management (1994) Dig Dis, 12, pp. 223-231; Rouillard, S., Lane, N.E., Hepatic osteodystrophy (2001) Hepatology, 33, pp. 301-307; Hsu, S.H., Tsai, K.S., Different age-related trends of bone and nonbone forms of alkaline phosphatase in chinese men and women (1997) Clin Chem, 43, pp. 186-188; Iki, M., Kajita, E., Dohi, Y., Nishino, H., Kusaka, Y., Tsuchida, C., Yamamoto, K., Ishii, Y., Age, menopause, bone turnover markers and lumbar bone loss in healthy japanese women (1996) Maturitas, 25, pp. 59-67; Melton III, L.J., Khosla, S., Atkinson, E.J., O'Fallon, W.M., Riggs, B.L., Relationship of bone turnover to bone density and fractures (1997) J Bone Miner Res, 12, pp. 1083-1091; Tsai, K.S., Pan, W.H., Hsu, S.H., Cheng, W.C., Chen, C.K., Chieng, P.U., Yang, R.S., Twu, S.T., Sexual differences in bone markers and bone mineral density of normal chinese (1996) Calcif Tissue Int, 59, pp. 454-460

PY - 2012

Y1 - 2012

N2 - Whether chronic hepatitis C virus (HCV) infection is a risk factor for the development of bone disease has long been controversial. For this reason, chronic HCV-infected participants (n = 69) were recruited into a prospective cohort study and underwent dual-energy X-ray absorptiometry for determination of bone mineral density (BMD). Fibrosis staging was evaluated according to the noninvasive index FIB-4. T scores at the femoral neck and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease and BMD. The study cohort was 41 % male with a mean age of 53.6 years. The mean BMD, Z score, and T score values of lumbar spine in chronic hepatitis C (CHC) patients were significantly lower than those in healthy controls (p

AB - Whether chronic hepatitis C virus (HCV) infection is a risk factor for the development of bone disease has long been controversial. For this reason, chronic HCV-infected participants (n = 69) were recruited into a prospective cohort study and underwent dual-energy X-ray absorptiometry for determination of bone mineral density (BMD). Fibrosis staging was evaluated according to the noninvasive index FIB-4. T scores at the femoral neck and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease and BMD. The study cohort was 41 % male with a mean age of 53.6 years. The mean BMD, Z score, and T score values of lumbar spine in chronic hepatitis C (CHC) patients were significantly lower than those in healthy controls (p

KW - Bone mineral density

KW - Osteodystrophy

KW - Osteoporosis

KW - Viral hepatitis

KW - alkaline phosphatase bone isoenzyme

KW - carboxy terminal telopeptide

KW - adult

KW - article

KW - body composition

KW - bone density

KW - disease association

KW - disease severity

KW - dual energy X ray absorptiometry

KW - female

KW - femur neck

KW - hepatitis C

KW - human

KW - liver fibrosis

KW - lumbar spine

KW - major clinical study

KW - male

KW - osteoporosis

KW - premenopause

KW - priority journal

KW - scoring system

KW - Absorptiometry, Photon

KW - Bone Density

KW - Bone Diseases, Metabolic

KW - Case-Control Studies

KW - Female

KW - Hepatitis C, Chronic

KW - Humans

KW - Liver Cirrhosis

KW - Male

KW - Middle Aged

KW - Premenopause

U2 - 10.1007/s00223-012-9653-y

DO - 10.1007/s00223-012-9653-y

M3 - Article

VL - 91

SP - 423

EP - 429

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 6

ER -