Association between autoimmune rheumatic diseases and the risk of dementia

Kang Lu, Hao Kuang Wang, Chih Ching Yeh, Chih Yuan Huang, Pi Shan Sung, Liang Chao Wang, Chih Hsin Muo, Fung Chang Sung, Han Jung Chen, Ying Chun Li, Li Ching Chang, Kuen Jer Tsai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim. Autoimmune rheumatic diseases (ARD) are characterized by systemic inflammation and may affect multiple organs and cause vascular events such as ischemic stroke and acute myocardial infarction. However, the association between ARD and increased risk of dementia is uncertain. This is a retrospective cohort study to investigate and compare the risk of dementia between patients clinically diagnosed with ARD and non-ARD patients during a 5-year follow-up period. Methods. Data were obtained from the Longitudinal Health Insurance Database 2000 (LHID2000). We included 1221 patients receiving ambulatory or hospitalization care and 6105 non-ARD patients; patients were matched by sex, age, and the year of index use of health care. Each patient was studied for 5 years to identify the subsequent manifestation of dementia. The data obtained were analyzed by Cox proportional hazard regression. Results. During the 5-year follow-up period, 30 ARD (2.48%) and 141 non-ARD patients (2.31%) developed dementia. During the 5-year follow-up period, there were no significant differences in the risks of any type of dementia (adjusted hazard ratio (HR), 1.18; 95% CI, 0.79-1.76) in the ARD group after adjusting for demographics and comorbidities. Conclusions. Within the 5-year period, patients with and without ARD were found to have similar risks of developing dementia.

Original languageEnglish
Article number861812
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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Rheumatic Diseases
Autoimmune Diseases
Dementia
Hazards
Health insurance
Health Insurance
Health care
Blood Vessels
Comorbidity
Hospitalization
Cohort Studies
Retrospective Studies
Stroke
Myocardial Infarction
Demography
Databases
Inflammation
Delivery of Health Care

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Lu, K., Wang, H. K., Yeh, C. C., Huang, C. Y., Sung, P. S., Wang, L. C., ... Tsai, K. J. (2014). Association between autoimmune rheumatic diseases and the risk of dementia. BioMed Research International, 2014, [861812]. https://doi.org/10.1155/2014/861812

Association between autoimmune rheumatic diseases and the risk of dementia. / Lu, Kang; Wang, Hao Kuang; Yeh, Chih Ching; Huang, Chih Yuan; Sung, Pi Shan; Wang, Liang Chao; Muo, Chih Hsin; Sung, Fung Chang; Chen, Han Jung; Li, Ying Chun; Chang, Li Ching; Tsai, Kuen Jer.

In: BioMed Research International, Vol. 2014, 861812, 2014.

Research output: Contribution to journalArticle

Lu, K, Wang, HK, Yeh, CC, Huang, CY, Sung, PS, Wang, LC, Muo, CH, Sung, FC, Chen, HJ, Li, YC, Chang, LC & Tsai, KJ 2014, 'Association between autoimmune rheumatic diseases and the risk of dementia', BioMed Research International, vol. 2014, 861812. https://doi.org/10.1155/2014/861812
Lu, Kang ; Wang, Hao Kuang ; Yeh, Chih Ching ; Huang, Chih Yuan ; Sung, Pi Shan ; Wang, Liang Chao ; Muo, Chih Hsin ; Sung, Fung Chang ; Chen, Han Jung ; Li, Ying Chun ; Chang, Li Ching ; Tsai, Kuen Jer. / Association between autoimmune rheumatic diseases and the risk of dementia. In: BioMed Research International. 2014 ; Vol. 2014.
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AU - Muo, Chih Hsin

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