Association between apolipoprotein E genotype and outcome of traumatic brain injury

Ming F. Chiang; J. G. Chang; C. J. Hu; L. Dunn; J. A R Nicoll

doi:10.1007/s00701-003-0069-3

Association between apolipoprotein E genotype and outcome of traumatic brain injury

Ming F. Chiang, J. G. Chang, C. J. Hu, L. Dunn, J. A R Nicoll

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Background. The prognosis of traumatic brain injury is quite variable and not fully explained by the known factors. This study is to examine if the polymorphism of apolipoprotein E (apoE) influences the outcome of traumatic brain injury. Methods. Over a period of twelve months, we prospectively studied 100 patients who sustained traumatic brain injuries and were admitted to our neurosurgical unit. Findings. Nineteen patients were apoE4(+) and 81 patients were apoE4(-). There was no significant difference between apoE4(+) and apoE4(-) groups in the cause of injury (p = 0.288), type of brain injury (p = 0.983) and choice of treatment (p = 0.88). The proportion of patients with a lower GCS (

Original language	English
Pages (from-to)	649-654
Number of pages	6
Journal	Acta Neurochirurgica
Volume	145
Issue number	8
DOIs	https://doi.org/10.1007/s00701-003-0069-3
Publication status	Published - Aug 1 2003
Externally published	Yes

Keywords

Apolipoprotein E
Genotype
PCR
Traumatic brain injury

ASJC Scopus subject areas

Clinical Neurology
Surgery

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10.1007/s00701-003-0069-3

Cite this

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abstract = "Background. The prognosis of traumatic brain injury is quite variable and not fully explained by the known factors. This study is to examine if the polymorphism of apolipoprotein E (apoE) influences the outcome of traumatic brain injury. Methods. Over a period of twelve months, we prospectively studied 100 patients who sustained traumatic brain injuries and were admitted to our neurosurgical unit. Findings. Nineteen patients were apoE4(+) and 81 patients were apoE4(-). There was no significant difference between apoE4(+) and apoE4(-) groups in the cause of injury (p = 0.288), type of brain injury (p = 0.983) and choice of treatment (p = 0.88). The proportion of patients with a lower GCS (",

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AU - Chiang, Ming F.

AU - Chang, J. G.

AU - Hu, C. J.

AU - Dunn, L.

AU - Nicoll, J. A R

PY - 2003/8/1

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Association between apolipoprotein E genotype and outcome of traumatic brain injury

Abstract

Keywords

ASJC Scopus subject areas

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