Association between apolipoprotein E genotype and outcome of traumatic brain injury

Ming F. Chiang, J. G. Chang, C. J. Hu, L. Dunn, J. A R Nicoll

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

Background. The prognosis of traumatic brain injury is quite variable and not fully explained by the known factors. This study is to examine if the polymorphism of apolipoprotein E (apoE) influences the outcome of traumatic brain injury. Methods. Over a period of twelve months, we prospectively studied 100 patients who sustained traumatic brain injuries and were admitted to our neurosurgical unit. Findings. Nineteen patients were apoE4(+) and 81 patients were apoE4(-). There was no significant difference between apoE4(+) and apoE4(-) groups in the cause of injury (p = 0.288), type of brain injury (p = 0.983) and choice of treatment (p = 0.88). The proportion of patients with a lower GCS (

Original languageEnglish
Pages (from-to)649-654
Number of pages6
JournalActa Neurochirurgica
Volume145
Issue number8
DOIs
Publication statusPublished - Aug 1 2003
Externally publishedYes

Keywords

  • Apolipoprotein E
  • Genotype
  • PCR
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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