Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population

E. W. Loh, N. L.S. Tang, D. T.S. Lee, S. I. Liu, Alfreda Stadlin

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21 Citations (Scopus)

Abstract

GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAγ2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed.

Original languageEnglish
Pages (from-to)439-443
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume144
Issue number4
DOIs
Publication statusPublished - Jun 5 2007
Externally publishedYes

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Keywords

  • 5q33
  • Chinese
  • GABA receptor subunit gene
  • Heroin dependence
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

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