Association analysis of dopamine D2-like receptor genes and methamphetamine abuse

Chih Ken Chen, Xun Hu, Shih Ku Lin, Pak C. Sham, El Wui Loh, Tao Li, Robin M. Murray, David M. Ball

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objectives: Substance use disorders are familial, and genetic factors explain a substantial degree of their familial aggregation. This study employs an association approach to examine the genetic underpinning of methamphetamine (MAMP) use and MAMP-induced psychosis. Methods: A total of 416 MAMP abusers from a hospital and a detention center in Taipei were interviewed with the Diagnostic Interview for Genetic Study and the Family Interview for Genetic Study. Genetic polymorphisms of D2-like dopamine receptor genes, DRD2 Taql A, DRD3 Ser-9-Gly, and DRD4 exon III variable number of tandem repeats, were compared between: (a) MAMP users as a whole and 435 normal controls, and (b) those 154 individuals with MAMP-induced psychosis and the 252 MAMP users with no psychosis. Results: None of the three markers we studied were associated with predisposition to psychosis among the MAMP abusers. The MAMP abusers had a higher (P = 0.011) prevalence of the seven-repeat allele of DRD4 than normal controls. Conclusions: Chance fluctuations in the frequency of rare alleles and ascertainment differences in the case and control samples cannot be ruled out. Therefore, further studies of the seven-repeat allele in MAMP abusers and controls should be performed before an association can be established.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalPsychiatric Genetics
Volume14
Issue number4
DOIs
Publication statusPublished - Dec 1 2004
Externally publishedYes

Keywords

  • Amphetamine-related disorders
  • Genes
  • Methamphetamine
  • Psychoses
  • Psychotic disorders
  • Substance induced

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Association analysis of dopamine D2-like receptor genes and methamphetamine abuse'. Together they form a unique fingerprint.

  • Cite this

    Chen, C. K., Hu, X., Lin, S. K., Sham, P. C., Loh, E. W., Li, T., Murray, R. M., & Ball, D. M. (2004). Association analysis of dopamine D2-like receptor genes and methamphetamine abuse. Psychiatric Genetics, 14(4), 223-226. https://doi.org/10.1097/00041444-200412000-00011