Association analysis of dopamine D2-like receptor genes and methamphetamine abuse

Chih Ken Chen, Xun Hu, Shih Ku Lin, Pak C. Sham, El Wui Loh, Tao Li, Robin M. Murray, David M. Ball

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objectives: Substance use disorders are familial, and genetic factors explain a substantial degree of their familial aggregation. This study employs an association approach to examine the genetic underpinning of methamphetamine (MAMP) use and MAMP-induced psychosis. Methods: A total of 416 MAMP abusers from a hospital and a detention center in Taipei were interviewed with the Diagnostic Interview for Genetic Study and the Family Interview for Genetic Study. Genetic polymorphisms of D2-like dopamine receptor genes, DRD2 Taql A, DRD3 Ser-9-Gly, and DRD4 exon III variable number of tandem repeats, were compared between: (a) MAMP users as a whole and 435 normal controls, and (b) those 154 individuals with MAMP-induced psychosis and the 252 MAMP users with no psychosis. Results: None of the three markers we studied were associated with predisposition to psychosis among the MAMP abusers. The MAMP abusers had a higher (P = 0.011) prevalence of the seven-repeat allele of DRD4 than normal controls. Conclusions: Chance fluctuations in the frequency of rare alleles and ascertainment differences in the case and control samples cannot be ruled out. Therefore, further studies of the seven-repeat allele in MAMP abusers and controls should be performed before an association can be established.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalPsychiatric Genetics
Volume14
Issue number4
DOIs
Publication statusPublished - Dec 1 2004
Externally publishedYes

Fingerprint

Dopamine D2 Receptors
Methamphetamine
Genes
Psychotic Disorders
Alleles
Interviews
Minisatellite Repeats
Genetic Polymorphisms
Gene Frequency
Substance-Related Disorders
Exons

Keywords

  • Amphetamine-related disorders
  • Genes
  • Methamphetamine
  • Psychoses
  • Psychotic disorders
  • Substance induced

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Cite this

Association analysis of dopamine D2-like receptor genes and methamphetamine abuse. / Chen, Chih Ken; Hu, Xun; Lin, Shih Ku; Sham, Pak C.; Loh, El Wui; Li, Tao; Murray, Robin M.; Ball, David M.

In: Psychiatric Genetics, Vol. 14, No. 4, 01.12.2004, p. 223-226.

Research output: Contribution to journalArticle

Chen, CK, Hu, X, Lin, SK, Sham, PC, Loh, EW, Li, T, Murray, RM & Ball, DM 2004, 'Association analysis of dopamine D2-like receptor genes and methamphetamine abuse', Psychiatric Genetics, vol. 14, no. 4, pp. 223-226. https://doi.org/10.1097/00041444-200412000-00011
Chen, Chih Ken ; Hu, Xun ; Lin, Shih Ku ; Sham, Pak C. ; Loh, El Wui ; Li, Tao ; Murray, Robin M. ; Ball, David M. / Association analysis of dopamine D2-like receptor genes and methamphetamine abuse. In: Psychiatric Genetics. 2004 ; Vol. 14, No. 4. pp. 223-226.
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