122 Citations (Scopus)


Objective: To investigate the correlation of blood flow detected by color Doppler sonography in the endometrial-subendometrial unit with pregnancy outcome of IVF-ET treatments. Design: Prospective clinical study. Setting: University setting. Patient(s): Six hundred twenty-three patients selected prospectively on the day of ET. Intervention(s): Transvaginal ultrasound examination was performed before ET. Main Outcome Measure(s): Association between pregnancy outcome and distribution of endometrial-subendometrial blood flow (primary outcome measure) and between pregnancy rate and endometrial measurements as well as uterine arterial blood flow (secondary outcome measures). Result(s): The overall pregnancy rate was 28.4% (177/623) per ET. The pregnancy and implantation rates of patients with the presence of both endometrial and subendometrial flow were 47.8% (64/134) and 24.2% (94/388); for patients with subendometrial flow only, 29.7% (102/343) and 15.8% (153/967); and for patients with no detectable endometrial-subendometrial flow, 7.5% (11/146) and 3.5% (13/376), respectively. The presence of both endometrial and subendometrial blood flow is indicative of good endometrial receptivity, whereas the absence of both represents a poor uterine environment. Nondetectable endometrial-subendometrial flow was associated with women who were older, had a thinner endometrium, and had higher uterine arterial resistance compared with those women who had detectable flow. Conclusion(s): Endometrial-subendometrial blood flow distribution pattern assessed by transvaginal color Doppler before ET is correlated with the implantation and pregnancy rate of IVF treatment.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalFertility and Sterility
Issue number2
Publication statusPublished - 2002


  • Blood flow
  • Color Doppler
  • Endometrial receptivity
  • Endometrial-subendometrial unit
  • In vitro fertilization

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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