Assessment of left ventricular end-systolic elastance from aortic pressure-left ventricular volume relations

Wen Shin Lee, Masaru Nakayama, Wen Pin Huang, Kuan Rau Chiou, Chih Cheng Wu, Erez Nevo, Barry Fetics, David A. Kass, Philip Yu An Ding, C. H. Chen

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Abstract

The left ventricular (LV) end-systolic pressure-volume relation (ESPVR) is a load-insensitive method for evaluating LV contractility, which needs invasive measurement. Some noninvasive methods substitute peak aortic pressure (Ps) for end-systolic LV pressure by assuming there is no difference between these pressures. However, this assumption has not been directly validated. With conductance catheter and dual micromanometers, ESPVRs and the slope (EesLV) were constructed from simultaneous LV pressures (LVP) and volumes, aortic pressures (AOP) and LV volumes (EesAO), and Ps and LV end-ejection volumes (VEE) (EesPP-EEV) during preload reduction in 50 subjects. The ratio of steady-state Ps over VEE (Ps/VEE) was also checked. AOP and LVP displayed differences of 11 ± 6 and -30 ± 12 mmHg at the onset and end-ejection, respectively, and -2 ± 4 mmHg at end-systole. EesAO and EesLV were nearly identical: EesAO = 0.97 × EesLV + 0.05, r2 = 0.99. EesPP-EEV correlated with EesLV (EesPP-EEV = 0.57 × EesLV + 0.61, r2 = 0.46) but with much more scatter. Ps/VEE correlated worst with EesLV. Central AOP can be substituted for LVP to derive EesLV. Other estimation methods yield weaker and poor correlations to directly measured Ees.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalHeart and Vessels
Volume16
Issue number3
DOIs
Publication statusPublished - May 14 2002
Externally publishedYes

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Keywords

  • Central aortic pressure
  • End-systolic pressure-volume relationship
  • Hemodynamics
  • Left ventricular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, W. S., Nakayama, M., Huang, W. P., Chiou, K. R., Wu, C. C., Nevo, E., Fetics, B., Kass, D. A., Ding, P. Y. A., & Chen, C. H. (2002). Assessment of left ventricular end-systolic elastance from aortic pressure-left ventricular volume relations. Heart and Vessels, 16(3), 99-104. https://doi.org/10.1007/s003800200003