精神分裂症病患飲食攝取及血液脂肪酸組成之評估

Translated title of the contribution: Assessment of Dietary Intake and Blood Fatty Acid Composition in Patients with Schizophrenia

Shih-Yi Huang, Sia Shan Wu, Chih Chiang Chiu, Chian Jue Kuo, Kuan Pin Su, Mong-Liang Lu

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate the dietary intake and blood fatty acid composition of patients with schizophrenia. A dietary assessment and blood fatty acids analysis of medicated day care schizophrenic patients (n=20) were measured and compared with a healthy control group (n=20). The results showed that BMl and calorie intake of patients were significantly higher than those of control subjects(p<0.05). For the adjusted nutrient intake, there were no significant differences in protein, fats and carbohydrate intakes between patients and control subjects. Oleic acid, linoleic acid, α-linolenic acid, and total unsaturated fatty acid intake of patients were significant higher(p<0.05). However, intake of other unsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were lower in patients than in control subjects. Percentage of plasma DHA and erythrocytic arachidonic acid (AA) in patients were significant lower than control subjects (p<0.05). A lower composition of both EPA and DHA in erythrocytes was also found in schizophrenic patients (p=0.064 and p=0.197), unfortunately, there were no significant difference. We concluded that the difference in dietary intake of patients could affect blood fatty acid composition. Since the specific polyunsaturated fatty acids as AA, EPA or DHA might play an important role in the psychopathology of schizophrenia in some studies; the symptoms of schizophrenia may be improved by education and nutritional intervention in the future.
Original languageTraditional Chinese
Pages (from-to)21-30
Number of pages10
JournalJournal of the Chinese Nutrition Society
Volume29
Issue number1
Publication statusPublished - 2004

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Schizophrenia
Fatty Acids
Docosahexaenoic Acids
Eicosapentaenoic Acid
Unsaturated Fatty Acids
Arachidonic Acid
Oleic Acid
Psychopathology
Erythrocytes
Fats
Carbohydrates
Education
Food
Control Groups
Proteins

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精神分裂症病患飲食攝取及血液脂肪酸組成之評估. / Huang, Shih-Yi; Wu, Sia Shan; Chiu, Chih Chiang; Kuo, Chian Jue; Su, Kuan Pin; Lu, Mong-Liang.

In: Journal of the Chinese Nutrition Society, Vol. 29, No. 1, 2004, p. 21-30.

Research output: Contribution to journalArticle

Huang, Shih-Yi ; Wu, Sia Shan ; Chiu, Chih Chiang ; Kuo, Chian Jue ; Su, Kuan Pin ; Lu, Mong-Liang. / 精神分裂症病患飲食攝取及血液脂肪酸組成之評估. In: Journal of the Chinese Nutrition Society. 2004 ; Vol. 29, No. 1. pp. 21-30.
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abstract = "The aim of this study was to evaluate the dietary intake and blood fatty acid composition of patients with schizophrenia. A dietary assessment and blood fatty acids analysis of medicated day care schizophrenic patients (n=20) were measured and compared with a healthy control group (n=20). The results showed that BMl and calorie intake of patients were significantly higher than those of control subjects(p<0.05). For the adjusted nutrient intake, there were no significant differences in protein, fats and carbohydrate intakes between patients and control subjects. Oleic acid, linoleic acid, α-linolenic acid, and total unsaturated fatty acid intake of patients were significant higher(p<0.05). However, intake of other unsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were lower in patients than in control subjects. Percentage of plasma DHA and erythrocytic arachidonic acid (AA) in patients were significant lower than control subjects (p<0.05). A lower composition of both EPA and DHA in erythrocytes was also found in schizophrenic patients (p=0.064 and p=0.197), unfortunately, there were no significant difference. We concluded that the difference in dietary intake of patients could affect blood fatty acid composition. Since the specific polyunsaturated fatty acids as AA, EPA or DHA might play an important role in the psychopathology of schizophrenia in some studies; the symptoms of schizophrenia may be improved by education and nutritional intervention in the future.",
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AU - Kuo, Chian Jue

AU - Su, Kuan Pin

AU - Lu, Mong-Liang

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N2 - The aim of this study was to evaluate the dietary intake and blood fatty acid composition of patients with schizophrenia. A dietary assessment and blood fatty acids analysis of medicated day care schizophrenic patients (n=20) were measured and compared with a healthy control group (n=20). The results showed that BMl and calorie intake of patients were significantly higher than those of control subjects(p<0.05). For the adjusted nutrient intake, there were no significant differences in protein, fats and carbohydrate intakes between patients and control subjects. Oleic acid, linoleic acid, α-linolenic acid, and total unsaturated fatty acid intake of patients were significant higher(p<0.05). However, intake of other unsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were lower in patients than in control subjects. Percentage of plasma DHA and erythrocytic arachidonic acid (AA) in patients were significant lower than control subjects (p<0.05). A lower composition of both EPA and DHA in erythrocytes was also found in schizophrenic patients (p=0.064 and p=0.197), unfortunately, there were no significant difference. We concluded that the difference in dietary intake of patients could affect blood fatty acid composition. Since the specific polyunsaturated fatty acids as AA, EPA or DHA might play an important role in the psychopathology of schizophrenia in some studies; the symptoms of schizophrenia may be improved by education and nutritional intervention in the future.

AB - The aim of this study was to evaluate the dietary intake and blood fatty acid composition of patients with schizophrenia. A dietary assessment and blood fatty acids analysis of medicated day care schizophrenic patients (n=20) were measured and compared with a healthy control group (n=20). The results showed that BMl and calorie intake of patients were significantly higher than those of control subjects(p<0.05). For the adjusted nutrient intake, there were no significant differences in protein, fats and carbohydrate intakes between patients and control subjects. Oleic acid, linoleic acid, α-linolenic acid, and total unsaturated fatty acid intake of patients were significant higher(p<0.05). However, intake of other unsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were lower in patients than in control subjects. Percentage of plasma DHA and erythrocytic arachidonic acid (AA) in patients were significant lower than control subjects (p<0.05). A lower composition of both EPA and DHA in erythrocytes was also found in schizophrenic patients (p=0.064 and p=0.197), unfortunately, there were no significant difference. We concluded that the difference in dietary intake of patients could affect blood fatty acid composition. Since the specific polyunsaturated fatty acids as AA, EPA or DHA might play an important role in the psychopathology of schizophrenia in some studies; the symptoms of schizophrenia may be improved by education and nutritional intervention in the future.

KW - n-3多元不飽和脂肪酸

KW - 飲食攝取

KW - 精神分裂症

KW - n-3 polyunsaturated fatty acid

KW - dietary intake

KW - schizophrenia

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