Abstract
Major depressive disorder (MDD) is highly prevalent, recurrent, and associated with functional impairment, morbidity, and mortality. Herein, we aimed to identify disruptions in functional connectomics among subjects with MDD by using resting-state functional magnetic resonance imaging (rs-fMRI). Sixteen subjects with MDD and thirty health controls completed resting-state fMRI scans and clinical assessments (e.g., Hamilton Depression Rating Scale (HAMD) and Hospital Anxiety and Depression Scale (HADS)). We found higher amplitude of low frequency fluctuations (ALFF) bilaterally in the hippocampus and amygdala among MDD subjects when compared to healthy controls. Using graph theoretical analysis, we found decreased clustering coefficient, local efficiency, and transitivity in the MDD patients. Our findings suggest a potential biomarker for differentiating individuals with MDD from individuals without MDD.
| Original language | English |
|---|---|
| Article number | e3147 |
| Journal | PeerJ |
| Volume | 2017 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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Keywords
- Functional connectome
- Graph theoretical analysis
- Major depressive disorder
- Resting-state functional magnetic resonance imaging
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
Cite this
Assessment of brain functional connectome alternations and correlation with depression and anxiety in major depressive disorders. / Chen, Vincent Chin Hung; Shen, Chao Yu; Liang, Sophie Hsin Yi; Li, Zhen Hui; Hsieh, Ming Hong; Tyan, Yeu Sheng; Lu, Mong Liang; Lee, Yena; McIntyre, Roger S.; Weng, Jun Cheng.
In: PeerJ, Vol. 2017, No. 11, e3147, 01.01.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of brain functional connectome alternations and correlation with depression and anxiety in major depressive disorders
AU - Chen, Vincent Chin Hung
AU - Shen, Chao Yu
AU - Liang, Sophie Hsin Yi
AU - Li, Zhen Hui
AU - Hsieh, Ming Hong
AU - Tyan, Yeu Sheng
AU - Lu, Mong Liang
AU - Lee, Yena
AU - McIntyre, Roger S.
AU - Weng, Jun Cheng
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Major depressive disorder (MDD) is highly prevalent, recurrent, and associated with functional impairment, morbidity, and mortality. Herein, we aimed to identify disruptions in functional connectomics among subjects with MDD by using resting-state functional magnetic resonance imaging (rs-fMRI). Sixteen subjects with MDD and thirty health controls completed resting-state fMRI scans and clinical assessments (e.g., Hamilton Depression Rating Scale (HAMD) and Hospital Anxiety and Depression Scale (HADS)). We found higher amplitude of low frequency fluctuations (ALFF) bilaterally in the hippocampus and amygdala among MDD subjects when compared to healthy controls. Using graph theoretical analysis, we found decreased clustering coefficient, local efficiency, and transitivity in the MDD patients. Our findings suggest a potential biomarker for differentiating individuals with MDD from individuals without MDD.
AB - Major depressive disorder (MDD) is highly prevalent, recurrent, and associated with functional impairment, morbidity, and mortality. Herein, we aimed to identify disruptions in functional connectomics among subjects with MDD by using resting-state functional magnetic resonance imaging (rs-fMRI). Sixteen subjects with MDD and thirty health controls completed resting-state fMRI scans and clinical assessments (e.g., Hamilton Depression Rating Scale (HAMD) and Hospital Anxiety and Depression Scale (HADS)). We found higher amplitude of low frequency fluctuations (ALFF) bilaterally in the hippocampus and amygdala among MDD subjects when compared to healthy controls. Using graph theoretical analysis, we found decreased clustering coefficient, local efficiency, and transitivity in the MDD patients. Our findings suggest a potential biomarker for differentiating individuals with MDD from individuals without MDD.
KW - Functional connectome
KW - Graph theoretical analysis
KW - Major depressive disorder
KW - Resting-state functional magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=85034624793&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034624793&partnerID=8YFLogxK
U2 - 10.7717/peerj.3147
DO - 10.7717/peerj.3147
M3 - Article
AN - SCOPUS:85034624793
VL - 2017
JO - PeerJ
JF - PeerJ
SN - 2167-8359
IS - 11
M1 - e3147
ER -