Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: Focus on the cancer hallmark of tumor angiogenesis

Zhiwei Hu, Samira A. Brooks, Valérian Dormoy, Chia Wen Hsu, Hsue Yin Hsu, Liang Tzung Lin, Thierry Massfelder, W. Kimryn Rathmell, Menghang Xia, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Dustin G. Brown, Kalan R. Prudhomme, Annamaria Colacci, Roslida A. Hamid, Chiara Mondello, Jayadev Raju, Elizabeth P. Ryan, Jordan WoodrickA. Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano Forte, Lorenzo Memeo, Hosni K. Salem, Leroy Lowe, Lasse Jensen, William H. Bisson, Nicole Kleinstreuer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

One of the important 'hallmarks' of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is well balanced and controlled by endogenous proangiogenic factors and antiangiogenic factors. However, factors produced by cancer cells, cancer stem cells and other cell types in the tumor stroma can disrupt the balance so that the tumor microenvironment favors tumor angiogenesis. These factors include vascular endothelial growth factor, endothelial tissue factor and other membrane bound receptors that mediate multiple intracellular signaling pathways that contribute to tumor angiogenesis. Though environmental exposures to certain chemicals have been found to initiate and promote tumor development, the role of these exposures (particularly to low doses of multiple substances), is largely unknown in relation to tumor angiogenesis. This review summarizes the evidence of the role of environmental chemical bioactivity and exposure in tumor angiogenesis and carcinogenesis. We identify a number of ubiquitous (prototypical) chemicals with disruptive potential that may warrant further investigation given their selectivity for high-throughput screening assay targets associated with proangiogenic pathways. We also consider the cross-hallmark relationships of a number of important angiogenic pathway targets with other cancer hallmarks and we make recommendations for future research. Understanding of the role of low-dose exposure of chemicals with disruptive potential could help us refine our approach to cancer risk assessment, and may ultimately aid in preventing cancer by reducing or eliminating exposures to synergistic mixtures of chemicals with carcinogenic potential.

Original languageEnglish
Pages (from-to)S184-S202
JournalCarcinogenesis
Volume36
DOIs
Publication statusPublished - Jun 1 2015

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Neoplasms
Physiologic Neovascularization
Vascular Tissue Neoplasms
High-Throughput Screening Assays
Tumor Microenvironment
Neoplastic Stem Cells
Environmental Exposure
Thromboplastin
Vascular Endothelial Growth Factor A
Endothelium
Carcinogenesis
Neoplasm Metastasis
Membranes

ASJC Scopus subject areas

  • Cancer Research

Cite this

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment : Focus on the cancer hallmark of tumor angiogenesis. / Hu, Zhiwei; Brooks, Samira A.; Dormoy, Valérian; Hsu, Chia Wen; Hsu, Hsue Yin; Lin, Liang Tzung; Massfelder, Thierry; Kimryn Rathmell, W.; Xia, Menghang; Al-Mulla, Fahd; Al-Temaimi, Rabeah; Amedei, Amedeo; Brown, Dustin G.; Prudhomme, Kalan R.; Colacci, Annamaria; Hamid, Roslida A.; Mondello, Chiara; Raju, Jayadev; Ryan, Elizabeth P.; Woodrick, Jordan; Ivana Scovassi, A.; Singh, Neetu; Vaccari, Monica; Roy, Rabindra; Forte, Stefano; Memeo, Lorenzo; Salem, Hosni K.; Lowe, Leroy; Jensen, Lasse; Bisson, William H.; Kleinstreuer, Nicole.

In: Carcinogenesis, Vol. 36, 01.06.2015, p. S184-S202.

Research output: Contribution to journalArticle

Hu, Z, Brooks, SA, Dormoy, V, Hsu, CW, Hsu, HY, Lin, LT, Massfelder, T, Kimryn Rathmell, W, Xia, M, Al-Mulla, F, Al-Temaimi, R, Amedei, A, Brown, DG, Prudhomme, KR, Colacci, A, Hamid, RA, Mondello, C, Raju, J, Ryan, EP, Woodrick, J, Ivana Scovassi, A, Singh, N, Vaccari, M, Roy, R, Forte, S, Memeo, L, Salem, HK, Lowe, L, Jensen, L, Bisson, WH & Kleinstreuer, N 2015, 'Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: Focus on the cancer hallmark of tumor angiogenesis', Carcinogenesis, vol. 36, pp. S184-S202. https://doi.org/10.1093/carcin/bgv036
Hu, Zhiwei ; Brooks, Samira A. ; Dormoy, Valérian ; Hsu, Chia Wen ; Hsu, Hsue Yin ; Lin, Liang Tzung ; Massfelder, Thierry ; Kimryn Rathmell, W. ; Xia, Menghang ; Al-Mulla, Fahd ; Al-Temaimi, Rabeah ; Amedei, Amedeo ; Brown, Dustin G. ; Prudhomme, Kalan R. ; Colacci, Annamaria ; Hamid, Roslida A. ; Mondello, Chiara ; Raju, Jayadev ; Ryan, Elizabeth P. ; Woodrick, Jordan ; Ivana Scovassi, A. ; Singh, Neetu ; Vaccari, Monica ; Roy, Rabindra ; Forte, Stefano ; Memeo, Lorenzo ; Salem, Hosni K. ; Lowe, Leroy ; Jensen, Lasse ; Bisson, William H. ; Kleinstreuer, Nicole. / Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment : Focus on the cancer hallmark of tumor angiogenesis. In: Carcinogenesis. 2015 ; Vol. 36. pp. S184-S202.
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AU - Hsu, Chia Wen

AU - Hsu, Hsue Yin

AU - Lin, Liang Tzung

AU - Massfelder, Thierry

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AU - Xia, Menghang

AU - Al-Mulla, Fahd

AU - Al-Temaimi, Rabeah

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AU - Brown, Dustin G.

AU - Prudhomme, Kalan R.

AU - Colacci, Annamaria

AU - Hamid, Roslida A.

AU - Mondello, Chiara

AU - Raju, Jayadev

AU - Ryan, Elizabeth P.

AU - Woodrick, Jordan

AU - Ivana Scovassi, A.

AU - Singh, Neetu

AU - Vaccari, Monica

AU - Roy, Rabindra

AU - Forte, Stefano

AU - Memeo, Lorenzo

AU - Salem, Hosni K.

AU - Lowe, Leroy

AU - Jensen, Lasse

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