Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: Statistical evaluation of epistasis

Li Sheng Chen, Jean Ching Yuan Fann, Sherry Yueh Hsia Chiu, Amy Ming Fang Yen, Tiina Wahlfors, Teuvo L. Tammela, Hsiu Hsi Chen, Anssi Auvinen, Johanna Schleutker

Research output: Contribution to journalArticle

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Abstract

Understanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the joint effect of two loci on rs4242382 at 8q24 and rs10486567 at 7p15.2 to this end. We analyzed the data from a Finnish family-based genetic study, which was composed of 947 men including 228 cases in 75 families, to evaluate the respective effects of the two loci on the disease penetrance; in particular, the occurrence and number of prostate cancer cases within a family were utilized to evaluate the interactions between the two loci under the additive and multiplicative Poisson regression models. The risk alleles A at rs4242382 (OR = 1.14, 95% CI 1.08-1.19, P2 = 13.89, P

Original languageEnglish
Article numbere89508
JournalPLoS One
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 25 2014

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epistasis
prostatic neoplasms
penetrance
Penetrance
loci
carcinogenesis
Prostatic Neoplasms
Carcinogenesis
Alleles
alleles
Familial Prostate cancer

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer : Statistical evaluation of epistasis. / Chen, Li Sheng; Fann, Jean Ching Yuan; Chiu, Sherry Yueh Hsia; Yen, Amy Ming Fang; Wahlfors, Tiina; Tammela, Teuvo L.; Chen, Hsiu Hsi; Auvinen, Anssi; Schleutker, Johanna.

In: PLoS One, Vol. 9, No. 2, e89508, 25.02.2014.

Research output: Contribution to journalArticle

Chen, Li Sheng ; Fann, Jean Ching Yuan ; Chiu, Sherry Yueh Hsia ; Yen, Amy Ming Fang ; Wahlfors, Tiina ; Tammela, Teuvo L. ; Chen, Hsiu Hsi ; Auvinen, Anssi ; Schleutker, Johanna. / Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer : Statistical evaluation of epistasis. In: PLoS One. 2014 ; Vol. 9, No. 2.
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