Ascorbigen induces dermal papilla cell proliferation in vitro, but fails to modulate chemotherapy-induced alopecia in vivo

Chih Hsiu Wang, Hsu Shan Huang, Niann Tzyy Dai, Ming Jen Sheu, Deh Ming Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Ascorbigen (ABG) is the predominant indole-derived compound from Brassica vegetables. In this study, we attempted to evaluate the effects of ABG on hair growth. To this end, we examined the proliferation of isolated human dermal papilla (DP) cells and keratinocytes after incubation in various concentrations (0-1.25 mM) of ABG. Furthermore, hair shaft regrowth was monitored in a mouse model of chemotherapy-induced alopecia (CIA), and hematoxylin and eosin staining was performed for histological analyses. We found that 1.25 mM ABG induced a 1.2-fold increase in the growth of DP cells, but not keratinocytes. However, ABG did not exert significant protective effects against CIA in the mouse model. These findings suggest that ABG may not be able to counteract CIA and that further investigation of the therapeutic potential of ABG in disease models is required.

Original languageEnglish
Pages (from-to)1863-1867
Number of pages5
JournalPhytotherapy Research
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 2013
Externally publishedYes

Keywords

  • ascorbigen
  • chemotherapy-induced alopecia
  • dermal papilla

ASJC Scopus subject areas

  • Pharmacology

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