Aryl hydrocarbon receptor controls murine mast cell homeostasis

Yufeng Zhou, Hui Ying Tung, Ying Ming Tsai, Shih Chang Hsu, Hui Wen Chang, Hirokazu Kawasaki, Hsiao Chun Tseng, Beverly Plunkett, Peisong Gao, Chih Hsing Hung, Becky M. Vonakis, Shau Ku Huang

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We propose that the aryl hydrocarbon receptor (AhR), a unique chemical sensor, is critical in controlling mast cell differentiation, growth, and function in vitro and in vivo. In antigen-stimulated mast cells, exposure to AhR ligands resulted in a calcium- and reactive oxygen species (ROS)-dependent increase of reversible oxidation in and reduced activity of SHP-2 phosphatase, leading to enhanced mast cell signaling, degranulation, and mediator and cytokine release, as well as the in vivo anaphylactic response. Surprisingly, significant mast cell deficiency was noted in AhR-null mice due to defective calcium signaling and mitochondrial function, concomitant with reduced expression of c-kit and cytosolic STAT proteins, as well as enhanced intracellular ROS and apoptosis. Consequently, AhR-null mast cells responded poorly to stimulation, demonstrating a critical role of AhR signaling in maintaining mast cell homeostasis.

Original languageEnglish
Pages (from-to)3195-3204
Number of pages10
JournalBlood
Volume121
Issue number16
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes

Fingerprint

Aryl Hydrocarbon Receptors
Mast Cells
Homeostasis
Reactive Oxygen Species
Cell signaling
Calcium
Cell Degranulation
Null Lymphocytes
Chemical sensors
Calcium Signaling
Phosphoric Monoester Hydrolases
Cell Differentiation
Apoptosis
Cytokines
Ligands
Antigens
Oxidation
Growth
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Zhou, Y., Tung, H. Y., Tsai, Y. M., Hsu, S. C., Chang, H. W., Kawasaki, H., ... Huang, S. K. (2013). Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood, 121(16), 3195-3204. https://doi.org/10.1182/blood-2012-08-453597

Aryl hydrocarbon receptor controls murine mast cell homeostasis. / Zhou, Yufeng; Tung, Hui Ying; Tsai, Ying Ming; Hsu, Shih Chang; Chang, Hui Wen; Kawasaki, Hirokazu; Tseng, Hsiao Chun; Plunkett, Beverly; Gao, Peisong; Hung, Chih Hsing; Vonakis, Becky M.; Huang, Shau Ku.

In: Blood, Vol. 121, No. 16, 01.01.2013, p. 3195-3204.

Research output: Contribution to journalArticle

Zhou, Y, Tung, HY, Tsai, YM, Hsu, SC, Chang, HW, Kawasaki, H, Tseng, HC, Plunkett, B, Gao, P, Hung, CH, Vonakis, BM & Huang, SK 2013, 'Aryl hydrocarbon receptor controls murine mast cell homeostasis', Blood, vol. 121, no. 16, pp. 3195-3204. https://doi.org/10.1182/blood-2012-08-453597
Zhou Y, Tung HY, Tsai YM, Hsu SC, Chang HW, Kawasaki H et al. Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood. 2013 Jan 1;121(16):3195-3204. https://doi.org/10.1182/blood-2012-08-453597
Zhou, Yufeng ; Tung, Hui Ying ; Tsai, Ying Ming ; Hsu, Shih Chang ; Chang, Hui Wen ; Kawasaki, Hirokazu ; Tseng, Hsiao Chun ; Plunkett, Beverly ; Gao, Peisong ; Hung, Chih Hsing ; Vonakis, Becky M. ; Huang, Shau Ku. / Aryl hydrocarbon receptor controls murine mast cell homeostasis. In: Blood. 2013 ; Vol. 121, No. 16. pp. 3195-3204.
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