Arthrospira Enhances Seroclearance in Patients with Chronic Hepatitis B Receiving Nucleos(t)ide Analogue through Modulation of TNF-α/IFN-γ Profile

Sheng Jie Shiue, Chao Ling Cheng, Han Shiang Shiue, Chun Nan Chen, Sheng Wei Cheng, Li Wei Wu, Ganbolor Jargalsaikhan, Tze Sian Chan, Hsin Yi Lin, Ming Shun Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic hepatitis B (CHB) virus infection, causing immune dysfunction and chronic hep-atitis, is one of the leading risk factors for hepatocellular cancer. We investigated how Arthrospira affected hepatitis B surface antigen (HBsAg) reduction in CHB patients under continued nucleos(t)ide analogues (NA). Sixty CHB patients who had been receiving NA for at least one year with unde-tectable HBV DNA were randomized into three groups: control and oral Arthrospira at 3 or 6 g daily add-on therapy groups. Patients were followed up for 6 months. Oral Arthrospira-diet mice were established to investigate the possible immunological mechanism of Arthrospira against HBV. Within 6 months, mean quantitative HBsAg (qHBsAg) decreased in the oral Arthrospira add-on therapy group. Interestingly, interferon gamma (IFN-γ) increased but TNF-α, interleukin 6 (IL-6), hepatic fibrosis, and steatosis decreased in the add-on groups. In mice, Arthrospira enhanced both innate and adaptive immune system, especially natural killer (NK) cell cytotoxicity, B cell activation, and the interleukin 2 (IL-2), IFN-γ immune response. Arthrospira may modulate IL-2-and TNF-α/IFN-γ-mediated B and T cell activation to reduce HBsAg. Also, Arthrospira has the potential to restore immune tolerance and enhance HBsAg seroclearance in CHB patients through promoting T, B, and NK cell activation.

Original languageEnglish
Article number2790
JournalNutrients
Volume14
Issue number14
DOIs
Publication statusPublished - Jul 2022

Keywords

  • B cell activation
  • chronic hepatitis B
  • IFN-γ
  • NK cell activation
  • quantitative hepatitis B surface antigen

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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