Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy

Chia Hui Chang, Ya Hui Hu, Yao Chou Tsai, Che Hsiung Wu, Shuo Meng Wang, Lian Yu Lin, Yen Hung Lin, Fumitoshi Satoh, Kwan Dun Wu, Vin Cent Wu

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The aim of this study was to show the effect of KCNJ5 mutational status on arterial stiffness in aldosterone-producing adenomas after adrenalectomy. Between February 2008 and January 2010, we prospectively enrolled 108 aldosteroneproducing adenoma patients undergoing adrenalectomy. We conducted repeated measurements of pulse wave velocity at baseline, 6 months, and 12 months after adrenalectomy, grouped by KCNJ5 mutational status. Prognostic factors of arterial stiffness and risk for hypertension at 12 months after adrenalectomy were analyzed after propensity score matching in a 1:1 ratio. After matching for age, sex and body mass index, 88 patients were divided equally into KCNJ5-mutant and non-mutant groups. KCNJ5 mutational status was not an independent variable in either the generalized estimating equation model (p = 0.147) or the percentage change of brachial-ankle pulse wave velocity (p = 0.106). The generalized additive model smoothing plot showed that aldosterone-producing adenoma patients who carried the KCNJ5 mutation and were aged between 37 and 60 may have a hypertension recovery advantage. According to our observations during a 12-month follow-up after adrenalectomy, KCNJ5 mutational status was not associated with improvement in arterial stiffness.

Original languageEnglish
Pages (from-to)29984-29995
Number of pages12
JournalOncotarget
Volume8
Issue number18
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Arterial stiffness
  • CAKS
  • KCNJ5 gene
  • PWV
  • TAIPAI

ASJC Scopus subject areas

  • Oncology

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