Arterial spin labeling perfusion study in the patients with subacute mild traumatic brain injury

Che Ming Lin, Ying Chi Tseng, Hui Ling Hsu, Chi Jen Chen, David Yen Ting Chen, Feng Xian Yan, Wen Ta Chiu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: This study uses a MRI technique, three-dimension pulse continuous arterial spin labeling (3D-PCASL), to measure the patient's cerebral blood flow (CBF) at the subacute stage of mild traumatic brain injury (MTBI) in order to analyze the relationship between cerebral blood flow and neurocognitive deficits. Objective: To provide the relationship between cortical CBF and neuropsychological dysfunction for the subacute MTBI patients. Methods: After MTBI, perfusion MR imaging technique (3D-PCASL) measures the CBF of MTBI patients (n = 23) within 1 month and that of normal controls (n = 22) to determine the quantity and location of perfusion defect. The correlation between CBF abnormalities and cognitive deficits was elucidated by combining the results of the neuropsychological tests of the patients. Result: We observed a substantial reduction in CBF in the bilateral frontal and left occipital cortex as compared with the normal persons. In addition, there were correlation between post concussive symptoms (including dizziness and simulator sickness) and CBF in the hypoperfused areas. The more severe symptom was correlated with higher CBF in bilateral frontal and left occipital lobes. Conclusion: First, this study determined that despite no significant abnormality detected on conventional CT and MRI studies, hypoperfusion was observed in MTBI group using 3D-PCASL technique in subacute stage, which suggested that this approach may increase sensitivity to MTBI. Second, the correlation between CBF and the severity of post concussive symptoms suggested that changes in cerebral hemodynamicsmay play a role in pathophysiology underlies the symptoms.

Original languageEnglish
Article numbere0149109
JournalPLoS One
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Cerebrovascular Circulation
Brain Concussion
Labeling
blood flow
Brain
Blood
Perfusion
brain
signs and symptoms (animals and humans)
Post-Concussion Syndrome
Occipital Lobe
Magnetic resonance imaging
Perfusion Imaging
Neuropsychological Tests
Dizziness
pathophysiology
methodology
cortex
Simulators

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Arterial spin labeling perfusion study in the patients with subacute mild traumatic brain injury. / Lin, Che Ming; Tseng, Ying Chi; Hsu, Hui Ling; Chen, Chi Jen; Chen, David Yen Ting; Yan, Feng Xian; Chiu, Wen Ta.

In: PLoS One, Vol. 11, No. 2, e0149109, 01.02.2016.

Research output: Contribution to journalArticle

@article{1784b68f71ab4591818608fea6a2977c,
title = "Arterial spin labeling perfusion study in the patients with subacute mild traumatic brain injury",
abstract = "Background: This study uses a MRI technique, three-dimension pulse continuous arterial spin labeling (3D-PCASL), to measure the patient's cerebral blood flow (CBF) at the subacute stage of mild traumatic brain injury (MTBI) in order to analyze the relationship between cerebral blood flow and neurocognitive deficits. Objective: To provide the relationship between cortical CBF and neuropsychological dysfunction for the subacute MTBI patients. Methods: After MTBI, perfusion MR imaging technique (3D-PCASL) measures the CBF of MTBI patients (n = 23) within 1 month and that of normal controls (n = 22) to determine the quantity and location of perfusion defect. The correlation between CBF abnormalities and cognitive deficits was elucidated by combining the results of the neuropsychological tests of the patients. Result: We observed a substantial reduction in CBF in the bilateral frontal and left occipital cortex as compared with the normal persons. In addition, there were correlation between post concussive symptoms (including dizziness and simulator sickness) and CBF in the hypoperfused areas. The more severe symptom was correlated with higher CBF in bilateral frontal and left occipital lobes. Conclusion: First, this study determined that despite no significant abnormality detected on conventional CT and MRI studies, hypoperfusion was observed in MTBI group using 3D-PCASL technique in subacute stage, which suggested that this approach may increase sensitivity to MTBI. Second, the correlation between CBF and the severity of post concussive symptoms suggested that changes in cerebral hemodynamicsmay play a role in pathophysiology underlies the symptoms.",
author = "Lin, {Che Ming} and Tseng, {Ying Chi} and Hsu, {Hui Ling} and Chen, {Chi Jen} and Chen, {David Yen Ting} and Yan, {Feng Xian} and Chiu, {Wen Ta}",
year = "2016",
month = "2",
day = "1",
doi = "10.1371/journal.pone.0149109",
language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

TY - JOUR

T1 - Arterial spin labeling perfusion study in the patients with subacute mild traumatic brain injury

AU - Lin, Che Ming

AU - Tseng, Ying Chi

AU - Hsu, Hui Ling

AU - Chen, Chi Jen

AU - Chen, David Yen Ting

AU - Yan, Feng Xian

AU - Chiu, Wen Ta

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background: This study uses a MRI technique, three-dimension pulse continuous arterial spin labeling (3D-PCASL), to measure the patient's cerebral blood flow (CBF) at the subacute stage of mild traumatic brain injury (MTBI) in order to analyze the relationship between cerebral blood flow and neurocognitive deficits. Objective: To provide the relationship between cortical CBF and neuropsychological dysfunction for the subacute MTBI patients. Methods: After MTBI, perfusion MR imaging technique (3D-PCASL) measures the CBF of MTBI patients (n = 23) within 1 month and that of normal controls (n = 22) to determine the quantity and location of perfusion defect. The correlation between CBF abnormalities and cognitive deficits was elucidated by combining the results of the neuropsychological tests of the patients. Result: We observed a substantial reduction in CBF in the bilateral frontal and left occipital cortex as compared with the normal persons. In addition, there were correlation between post concussive symptoms (including dizziness and simulator sickness) and CBF in the hypoperfused areas. The more severe symptom was correlated with higher CBF in bilateral frontal and left occipital lobes. Conclusion: First, this study determined that despite no significant abnormality detected on conventional CT and MRI studies, hypoperfusion was observed in MTBI group using 3D-PCASL technique in subacute stage, which suggested that this approach may increase sensitivity to MTBI. Second, the correlation between CBF and the severity of post concussive symptoms suggested that changes in cerebral hemodynamicsmay play a role in pathophysiology underlies the symptoms.

AB - Background: This study uses a MRI technique, three-dimension pulse continuous arterial spin labeling (3D-PCASL), to measure the patient's cerebral blood flow (CBF) at the subacute stage of mild traumatic brain injury (MTBI) in order to analyze the relationship between cerebral blood flow and neurocognitive deficits. Objective: To provide the relationship between cortical CBF and neuropsychological dysfunction for the subacute MTBI patients. Methods: After MTBI, perfusion MR imaging technique (3D-PCASL) measures the CBF of MTBI patients (n = 23) within 1 month and that of normal controls (n = 22) to determine the quantity and location of perfusion defect. The correlation between CBF abnormalities and cognitive deficits was elucidated by combining the results of the neuropsychological tests of the patients. Result: We observed a substantial reduction in CBF in the bilateral frontal and left occipital cortex as compared with the normal persons. In addition, there were correlation between post concussive symptoms (including dizziness and simulator sickness) and CBF in the hypoperfused areas. The more severe symptom was correlated with higher CBF in bilateral frontal and left occipital lobes. Conclusion: First, this study determined that despite no significant abnormality detected on conventional CT and MRI studies, hypoperfusion was observed in MTBI group using 3D-PCASL technique in subacute stage, which suggested that this approach may increase sensitivity to MTBI. Second, the correlation between CBF and the severity of post concussive symptoms suggested that changes in cerebral hemodynamicsmay play a role in pathophysiology underlies the symptoms.

UR - http://www.scopus.com/inward/record.url?scp=84960502254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960502254&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0149109

DO - 10.1371/journal.pone.0149109

M3 - Article

C2 - 26871696

AN - SCOPUS:84960502254

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 2

M1 - e0149109

ER -