Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

Hsiu Chen Lin, Yung Kai Huang, Horng Sheng Shiue, Liang Sien Chen, Cheuk Sing Choy, Shiau Rung Huang, Bor Cheng Han, Yu Mei Hsueh

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMAV percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p <0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalFood and Chemical Toxicology
Volume74
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Methylation
Arsenic
arsenic
insulin resistance
methylation
Insulin Resistance
obesity
Obesity
Insulin
middle school students
Students
elementary students
Taiwan
cacodylic acid
Cacodylic Acid
hydrides
arsenites
Atomic absorption spectrometry
arsenates
elementary schools

Keywords

  • Adolescents
  • Arsenic methylation capability
  • HOMA-IR
  • Insulin resistance
  • Obesity

ASJC Scopus subject areas

  • Food Science
  • Toxicology
  • Medicine(all)

Cite this

Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents. / Lin, Hsiu Chen; Huang, Yung Kai; Shiue, Horng Sheng; Chen, Liang Sien; Choy, Cheuk Sing; Huang, Shiau Rung; Han, Bor Cheng; Hsueh, Yu Mei.

In: Food and Chemical Toxicology, Vol. 74, 01.12.2014, p. 60-67.

Research output: Contribution to journalArticle

Lin, Hsiu Chen ; Huang, Yung Kai ; Shiue, Horng Sheng ; Chen, Liang Sien ; Choy, Cheuk Sing ; Huang, Shiau Rung ; Han, Bor Cheng ; Hsueh, Yu Mei. / Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents. In: Food and Chemical Toxicology. 2014 ; Vol. 74. pp. 60-67.
@article{3339c82f78a342658d8a3448d851185d,
title = "Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents",
abstract = "The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMAV percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p <0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.",
keywords = "Adolescents, Arsenic methylation capability, HOMA-IR, Insulin resistance, Obesity",
author = "Lin, {Hsiu Chen} and Huang, {Yung Kai} and Shiue, {Horng Sheng} and Chen, {Liang Sien} and Choy, {Cheuk Sing} and Huang, {Shiau Rung} and Han, {Bor Cheng} and Hsueh, {Yu Mei}",
year = "2014",
month = "12",
day = "1",
doi = "10.1016/j.fct.2014.08.018",
language = "English",
volume = "74",
pages = "60--67",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

AU - Lin, Hsiu Chen

AU - Huang, Yung Kai

AU - Shiue, Horng Sheng

AU - Chen, Liang Sien

AU - Choy, Cheuk Sing

AU - Huang, Shiau Rung

AU - Han, Bor Cheng

AU - Hsueh, Yu Mei

PY - 2014/12/1

Y1 - 2014/12/1

N2 - The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMAV percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p <0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.

AB - The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMAV percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p <0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.

KW - Adolescents

KW - Arsenic methylation capability

KW - HOMA-IR

KW - Insulin resistance

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84907819657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907819657&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2014.08.018

DO - 10.1016/j.fct.2014.08.018

M3 - Article

C2 - 25241017

AN - SCOPUS:84907819657

VL - 74

SP - 60

EP - 67

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -