Arsenic methylation capability and human health

Yu Mei Hsueh, Yung Kai Huang, Chi Jung Chung

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The metabolism of inorganic arsenic takes place through a series of reactions, including reduction and oxidative methylation reactions. Biomethylation is considered a major detoxification pathway for inorganic arsenic. However, interspecies differences exist according to the efficiency with which inorganic arsenic is metabolized and excreted in urine. Intermediate trivalent methylated arsenic species are more cytotoxic and genotoxic than inorganic compounds. The arsenic methylation profile is influenced by demographic characteristics, lifestyle, diet and genetic susceptibility. Inefficient methylation is related to the risk of cancer and noncancer disease.

Original languageEnglish
Title of host publicationHealth Hazards of Arsenic Poisoning Environmental: From Epidemic to Pandemic
PublisherWorld Scientific Publishing Co.
Pages193-212
Number of pages20
ISBN (Electronic)9789814291828
ISBN (Print)9814291811, 9789814291811
DOIs
Publication statusPublished - Jan 1 2011

Fingerprint

methylation
Arsenic
Methylation
arsenic
Health
inorganic compound
Genetic Predisposition to Disease
detoxification
lifestyle
urine
Life Style
cancer
metabolism
Demography
human health
Urine
diet
Diet
Neoplasms

ASJC Scopus subject areas

  • Environmental Science(all)
  • Medicine(all)

Cite this

Hsueh, Y. M., Huang, Y. K., & Chung, C. J. (2011). Arsenic methylation capability and human health. In Health Hazards of Arsenic Poisoning Environmental: From Epidemic to Pandemic (pp. 193-212). World Scientific Publishing Co.. https://doi.org/10.1142/9789814291828_0012

Arsenic methylation capability and human health. / Hsueh, Yu Mei; Huang, Yung Kai; Chung, Chi Jung.

Health Hazards of Arsenic Poisoning Environmental: From Epidemic to Pandemic. World Scientific Publishing Co., 2011. p. 193-212.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hsueh, YM, Huang, YK & Chung, CJ 2011, Arsenic methylation capability and human health. in Health Hazards of Arsenic Poisoning Environmental: From Epidemic to Pandemic. World Scientific Publishing Co., pp. 193-212. https://doi.org/10.1142/9789814291828_0012
Hsueh YM, Huang YK, Chung CJ. Arsenic methylation capability and human health. In Health Hazards of Arsenic Poisoning Environmental: From Epidemic to Pandemic. World Scientific Publishing Co. 2011. p. 193-212 https://doi.org/10.1142/9789814291828_0012
Hsueh, Yu Mei ; Huang, Yung Kai ; Chung, Chi Jung. / Arsenic methylation capability and human health. Health Hazards of Arsenic Poisoning Environmental: From Epidemic to Pandemic. World Scientific Publishing Co., 2011. pp. 193-212
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