Arsenic methylation and skin cancer risk in Southwestern Taiwan

Yen Ching Chen, Yu Liang Leon Guo, Huey Jen Jenny Su, Yu Mei Hsueh, Thomas J. Smith, Louise M. Ryan, Meei Shyuan Lee, Sheau Chiou Chao, Julia Yu Yun Lee, David C. Christiani

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Arsenic is a known carcinogen, but data are especially lacking on the health effects of low-level exposure, and on the health significance of methylation ability We conducted a case-control study (76 cases and 224 controls from 1996 to 1999) in southwestern Taiwan to explore the association among primary and secondary arsenic methylation index (PMI and SMI, respectively), cumulative arsenic exposure (CAE), and the risk of skin cancer. As compared with the controls, the skin cancer group reported more sun exposure (P = 0.02) and had a lower BMI (P = 0.03), as well as lower education level (P = 0.01). Skin cancer patients and controls were similar with regard to age, gender, smoking and alcohol consumption. Given a low SMI (≤5), CAE > 15 mg/L-year was associated with an increased risk of skin cancer (OR, 7.48; 95% CI, 1.65-33.99) compared to a CAE ≤ 2 mg/L-year. Given the same level of PMI, SMI, and CAE, men had a higher risk of skin cancer (OR, 4.04; 95% CI, 1.46-11.22) when compared to women. Subjects with low SMI and high CAE have a substantially increased risk of skin cancer. Males in all strata of arsenic exposure and methylation ability had a higher risk of skin cancer than women.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalJournal of Occupational and Environmental Medicine
Volume45
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

Fingerprint

Arsenic
Skin Neoplasms
Taiwan
Methylation
Aptitude
Health
Solar System
Alcohol Drinking
Carcinogens
Case-Control Studies
Smoking
Education

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Chen, Y. C., Guo, Y. L. L., Su, H. J. J., Hsueh, Y. M., Smith, T. J., Ryan, L. M., ... Christiani, D. C. (2003). Arsenic methylation and skin cancer risk in Southwestern Taiwan. Journal of Occupational and Environmental Medicine, 45(3), 241-248. https://doi.org/10.1097/01.jom.0000058336.05741.e8

Arsenic methylation and skin cancer risk in Southwestern Taiwan. / Chen, Yen Ching; Guo, Yu Liang Leon; Su, Huey Jen Jenny; Hsueh, Yu Mei; Smith, Thomas J.; Ryan, Louise M.; Lee, Meei Shyuan; Chao, Sheau Chiou; Lee, Julia Yu Yun; Christiani, David C.

In: Journal of Occupational and Environmental Medicine, Vol. 45, No. 3, 01.03.2003, p. 241-248.

Research output: Contribution to journalArticle

Chen, YC, Guo, YLL, Su, HJJ, Hsueh, YM, Smith, TJ, Ryan, LM, Lee, MS, Chao, SC, Lee, JYY & Christiani, DC 2003, 'Arsenic methylation and skin cancer risk in Southwestern Taiwan', Journal of Occupational and Environmental Medicine, vol. 45, no. 3, pp. 241-248. https://doi.org/10.1097/01.jom.0000058336.05741.e8
Chen, Yen Ching ; Guo, Yu Liang Leon ; Su, Huey Jen Jenny ; Hsueh, Yu Mei ; Smith, Thomas J. ; Ryan, Louise M. ; Lee, Meei Shyuan ; Chao, Sheau Chiou ; Lee, Julia Yu Yun ; Christiani, David C. / Arsenic methylation and skin cancer risk in Southwestern Taiwan. In: Journal of Occupational and Environmental Medicine. 2003 ; Vol. 45, No. 3. pp. 241-248.
@article{05e0e11352d54200bc84f118d3b35c80,
title = "Arsenic methylation and skin cancer risk in Southwestern Taiwan",
abstract = "Arsenic is a known carcinogen, but data are especially lacking on the health effects of low-level exposure, and on the health significance of methylation ability We conducted a case-control study (76 cases and 224 controls from 1996 to 1999) in southwestern Taiwan to explore the association among primary and secondary arsenic methylation index (PMI and SMI, respectively), cumulative arsenic exposure (CAE), and the risk of skin cancer. As compared with the controls, the skin cancer group reported more sun exposure (P = 0.02) and had a lower BMI (P = 0.03), as well as lower education level (P = 0.01). Skin cancer patients and controls were similar with regard to age, gender, smoking and alcohol consumption. Given a low SMI (≤5), CAE > 15 mg/L-year was associated with an increased risk of skin cancer (OR, 7.48; 95{\%} CI, 1.65-33.99) compared to a CAE ≤ 2 mg/L-year. Given the same level of PMI, SMI, and CAE, men had a higher risk of skin cancer (OR, 4.04; 95{\%} CI, 1.46-11.22) when compared to women. Subjects with low SMI and high CAE have a substantially increased risk of skin cancer. Males in all strata of arsenic exposure and methylation ability had a higher risk of skin cancer than women.",
author = "Chen, {Yen Ching} and Guo, {Yu Liang Leon} and Su, {Huey Jen Jenny} and Hsueh, {Yu Mei} and Smith, {Thomas J.} and Ryan, {Louise M.} and Lee, {Meei Shyuan} and Chao, {Sheau Chiou} and Lee, {Julia Yu Yun} and Christiani, {David C.}",
year = "2003",
month = "3",
day = "1",
doi = "10.1097/01.jom.0000058336.05741.e8",
language = "English",
volume = "45",
pages = "241--248",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Arsenic methylation and skin cancer risk in Southwestern Taiwan

AU - Chen, Yen Ching

AU - Guo, Yu Liang Leon

AU - Su, Huey Jen Jenny

AU - Hsueh, Yu Mei

AU - Smith, Thomas J.

AU - Ryan, Louise M.

AU - Lee, Meei Shyuan

AU - Chao, Sheau Chiou

AU - Lee, Julia Yu Yun

AU - Christiani, David C.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Arsenic is a known carcinogen, but data are especially lacking on the health effects of low-level exposure, and on the health significance of methylation ability We conducted a case-control study (76 cases and 224 controls from 1996 to 1999) in southwestern Taiwan to explore the association among primary and secondary arsenic methylation index (PMI and SMI, respectively), cumulative arsenic exposure (CAE), and the risk of skin cancer. As compared with the controls, the skin cancer group reported more sun exposure (P = 0.02) and had a lower BMI (P = 0.03), as well as lower education level (P = 0.01). Skin cancer patients and controls were similar with regard to age, gender, smoking and alcohol consumption. Given a low SMI (≤5), CAE > 15 mg/L-year was associated with an increased risk of skin cancer (OR, 7.48; 95% CI, 1.65-33.99) compared to a CAE ≤ 2 mg/L-year. Given the same level of PMI, SMI, and CAE, men had a higher risk of skin cancer (OR, 4.04; 95% CI, 1.46-11.22) when compared to women. Subjects with low SMI and high CAE have a substantially increased risk of skin cancer. Males in all strata of arsenic exposure and methylation ability had a higher risk of skin cancer than women.

AB - Arsenic is a known carcinogen, but data are especially lacking on the health effects of low-level exposure, and on the health significance of methylation ability We conducted a case-control study (76 cases and 224 controls from 1996 to 1999) in southwestern Taiwan to explore the association among primary and secondary arsenic methylation index (PMI and SMI, respectively), cumulative arsenic exposure (CAE), and the risk of skin cancer. As compared with the controls, the skin cancer group reported more sun exposure (P = 0.02) and had a lower BMI (P = 0.03), as well as lower education level (P = 0.01). Skin cancer patients and controls were similar with regard to age, gender, smoking and alcohol consumption. Given a low SMI (≤5), CAE > 15 mg/L-year was associated with an increased risk of skin cancer (OR, 7.48; 95% CI, 1.65-33.99) compared to a CAE ≤ 2 mg/L-year. Given the same level of PMI, SMI, and CAE, men had a higher risk of skin cancer (OR, 4.04; 95% CI, 1.46-11.22) when compared to women. Subjects with low SMI and high CAE have a substantially increased risk of skin cancer. Males in all strata of arsenic exposure and methylation ability had a higher risk of skin cancer than women.

UR - http://www.scopus.com/inward/record.url?scp=0347296273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347296273&partnerID=8YFLogxK

U2 - 10.1097/01.jom.0000058336.05741.e8

DO - 10.1097/01.jom.0000058336.05741.e8

M3 - Article

VL - 45

SP - 241

EP - 248

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

SN - 1076-2752

IS - 3

ER -