Arsenic-induced QT dispersion is associated with atherosclerotic diseases and predicts long-term cardiovascular mortality in subjects with previous exposure to arsenic

A 17-year follow-up study

Chih Hao Wang, Chi Ling Chen, Chuhsing Kate Hsiao, Fu Tien Chiang, Ling I. Hsu, Hung Yi Chiou, Yu Mei Hsueh, Meei Maan Wu, Chien Jen Chen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Chronic arsenic poisoning is a major worldwide public health problem. Recently, we had reported chronic arsenic poisoning was dose-dependently associated with ventricular abnormalities quantified by electrocardiographic QT prolongation linking to atherosclerotic diseases. An association of chronic arsenic poisoning with ventricular repolarization inhomogeneity quantified by QT dispersion (QTD) is of particular interest from a theoretical and practical perspective. We aimed to further elucidate (1) the association of chronic arsenic exposure with ventricular abnormalities quantified by QTD, (2) the association of QTD with atherosclerotic diseases and (3) the predictability of QTD for long-term mortality in subjects with chronic arsenic poisoning. We followed up 280 men and 355 women living in arseniasis-endemic area in southwestern coast in Taiwan for 17 years. QTD in electrocardiogram and carotid intima-media thickness by ultrasonography were measured. Coronary artery disease was diagnosed by an abnormal electrocardiogram and a definite history. Cumulative arsenic exposure was significantly associated with QTD showing a dose-response relationship (P <0.001). Significant associations of the QTD with coronary artery disease and carotid atherosclerosis existed after adjustment for potential confounders in the multiple linear regression analysis (all P values <0.05). In the multivariate Cox regression analyses, the hazard ratios (95% confidence interval, P value) of cumulative cardiovascular and all-cause mortality were 3.9 (2.1-6.2, P = 0.002) and 1.4 (0.9-2.3, P = 0.10), respectively, for QTD ≥ 65 ms compared with QTD <65. QTD may be indicated as an early biomarker for atherosclerotic diseases and a significant and strong predictor of cardiovascular mortality in population with chronic arsenic exposure.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalCardiovascular Toxicology
Volume10
Issue number1
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Arsenic Poisoning
A 17
Arsenic
Mortality
Coronary Artery Disease
Electrocardiography
Regression Analysis
Carotid Intima-Media Thickness
Carotid Artery Diseases
Taiwan
Association reactions
Linear Models
Ultrasonography
Public Health
Biomarkers
History
Confidence Intervals
Population
Public health
Medical problems

Keywords

  • Arsenic
  • Atherosclerotic diseases
  • Cardiovascular mortality
  • Coronary artery disease
  • QT dispersion

ASJC Scopus subject areas

  • Toxicology
  • Cardiology and Cardiovascular Medicine
  • Molecular Biology

Cite this

Arsenic-induced QT dispersion is associated with atherosclerotic diseases and predicts long-term cardiovascular mortality in subjects with previous exposure to arsenic : A 17-year follow-up study. / Wang, Chih Hao; Chen, Chi Ling; Hsiao, Chuhsing Kate; Chiang, Fu Tien; Hsu, Ling I.; Chiou, Hung Yi; Hsueh, Yu Mei; Wu, Meei Maan; Chen, Chien Jen.

In: Cardiovascular Toxicology, Vol. 10, No. 1, 03.2010, p. 17-26.

Research output: Contribution to journalArticle

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abstract = "Chronic arsenic poisoning is a major worldwide public health problem. Recently, we had reported chronic arsenic poisoning was dose-dependently associated with ventricular abnormalities quantified by electrocardiographic QT prolongation linking to atherosclerotic diseases. An association of chronic arsenic poisoning with ventricular repolarization inhomogeneity quantified by QT dispersion (QTD) is of particular interest from a theoretical and practical perspective. We aimed to further elucidate (1) the association of chronic arsenic exposure with ventricular abnormalities quantified by QTD, (2) the association of QTD with atherosclerotic diseases and (3) the predictability of QTD for long-term mortality in subjects with chronic arsenic poisoning. We followed up 280 men and 355 women living in arseniasis-endemic area in southwestern coast in Taiwan for 17 years. QTD in electrocardiogram and carotid intima-media thickness by ultrasonography were measured. Coronary artery disease was diagnosed by an abnormal electrocardiogram and a definite history. Cumulative arsenic exposure was significantly associated with QTD showing a dose-response relationship (P <0.001). Significant associations of the QTD with coronary artery disease and carotid atherosclerosis existed after adjustment for potential confounders in the multiple linear regression analysis (all P values <0.05). In the multivariate Cox regression analyses, the hazard ratios (95{\%} confidence interval, P value) of cumulative cardiovascular and all-cause mortality were 3.9 (2.1-6.2, P = 0.002) and 1.4 (0.9-2.3, P = 0.10), respectively, for QTD ≥ 65 ms compared with QTD <65. QTD may be indicated as an early biomarker for atherosclerotic diseases and a significant and strong predictor of cardiovascular mortality in population with chronic arsenic exposure.",
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