Arsenic in drinking water and incidence of urinary cancers

How Ran Guo, Han-Sun Chiang, Howard Hu, Stuart R. Lipsitz, Richard R. Monson

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The associations between arsenic ingestion and cancers of the bladder and kidney have been documented in Taiwan. To evaluate further such associations for urinary cancers of various cell types, we conducted an ecologic study encompassing 243 townships using cancer registry data of patients diagnosed between 1980 and 1987. We used the proportions of wells with various specified arsenic levels in each township as indicators of exposure and evaluated the effects of urbanization and smoking by an urbanization index and the number of cigarettes sold per capita. In both genders, we observed associations of high arsenic levels in drinking water with transitional cell carcinomas of the bladder, kidney, and ureter and all urethral cancers combined. We also observed such associations in adenocarcinomas of the bladder in males, but not in squamous cell carcinomas of the bladder or renal cell carcinomas or nephroblastomas of the kidney. There was also a positive association between the urbanization index and transitional cell carcinomas of the ureter in males. The number of cigarettes sold per capita was not a good predictor for urinary cancers. The results indicate that the carcinogenicity of arsenic may be cell type specific.

Original languageEnglish
Pages (from-to)545-550
Number of pages6
JournalEpidemiology
Volume8
Issue number5
DOIs
Publication statusPublished - Sep 1997

Fingerprint

Arsenic
Drinking Water
Urbanization
Urinary Bladder
Transitional Cell Carcinoma
Incidence
Ureter
Tobacco Products
Neoplasms
Urethral Neoplasms
Kidney
Wilms Tumor
Kidney Neoplasms
Taiwan
Renal Cell Carcinoma
Urinary Bladder Neoplasms
Registries
Squamous Cell Carcinoma
Adenocarcinoma
Eating

Keywords

  • Arsenic
  • Cancer
  • Cigarette smoking
  • Drinking water
  • Ecologic study
  • Histologic subtypes
  • Urbanization
  • Urinary system

ASJC Scopus subject areas

  • Epidemiology

Cite this

Guo, H. R., Chiang, H-S., Hu, H., Lipsitz, S. R., & Monson, R. R. (1997). Arsenic in drinking water and incidence of urinary cancers. Epidemiology, 8(5), 545-550. https://doi.org/10.1097/00001648-199709000-00012

Arsenic in drinking water and incidence of urinary cancers. / Guo, How Ran; Chiang, Han-Sun; Hu, Howard; Lipsitz, Stuart R.; Monson, Richard R.

In: Epidemiology, Vol. 8, No. 5, 09.1997, p. 545-550.

Research output: Contribution to journalArticle

Guo, HR, Chiang, H-S, Hu, H, Lipsitz, SR & Monson, RR 1997, 'Arsenic in drinking water and incidence of urinary cancers', Epidemiology, vol. 8, no. 5, pp. 545-550. https://doi.org/10.1097/00001648-199709000-00012
Guo, How Ran ; Chiang, Han-Sun ; Hu, Howard ; Lipsitz, Stuart R. ; Monson, Richard R. / Arsenic in drinking water and incidence of urinary cancers. In: Epidemiology. 1997 ; Vol. 8, No. 5. pp. 545-550.
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