Arsenic, DNA damage, and cancers of bladder and kidney – a long-term follow-up of residents in arseniasis endemic area of north-eastern Taiwan

S. L. Wang, S. F. Tsai, L. I. Hsu, C. J. Chen, K. H. Hsu, H. Y. Chiou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim is to assess dose-response association between arsenic exposure, DNA damage biomarkers, and the incidence of bladder and kidney cancers. A total of 8102 men and women from 3901 households have been enrolled in 1991–1994, and followed in 2011–2014. The data collected included well water consumption, habits of cigarette smoking, alcohol consumption, exercise and diet, through standardized personal interview. The individual urinary arsenic species were quantified using high-performance liquid chromatography–inductively coupled plasma/mass spectrometry (HPLC-ICP/MS). For assessment of oxidative and methylated DNA lesions and depletion, urinary 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) and N7-methylguanine (N7-MeG) were measured respectively, using liquid chromatography/tandem mass spectrometry (LC-MS/MS). The National Cancer Registry Data using the pathology finding defined bladder and kidney cancers. Urinary levels of the two DNA adduct increased significantly with increasing urinary arsenic level (iAs+MMA+DMA) in both men (β = 0.82, β = 0.34 for 8-oxodG and N7-MeG, respectively, p < 0.0001 for both) and women (β = 1.03, 0.38, p < 0.0001) adjusted for potential confounders. Incidence rate of bladder and kidney cancer using person-years tended to be the highest for higher urinary inorganic and methylated arsenic with higher DNA adduct level than the medians. It is suggested that subjects with high arsenic exposure experienced further cancer risk with high level of DNA damage biomarker.

Original languageEnglish
Title of host publicationEnvironmental Arsenic in a ChangingWorld - 7th International Congress and Exhibition Arsenic in the Environment, 2018
EditorsYong-Guan Zhu, Yong-Guan Zhu, Huaming Guo, Huaming Guo, Prosun Bhattacharya, Prosun Bhattacharya, Jochen Bundschuh, Arslan Ahmad, Arslan Ahmad, Arslan Ahmad, Ravi Naidu, Ravi Naidu
PublisherCRC Press/Balkema
Pages317-318
Number of pages2
ISBN (Print)9781138486096
DOIs
Publication statusPublished - 2018
Event7th International Congress and Exhibition Arsenic in the Environment, 2018 - Beijing, China
Duration: Jul 1 2018Jul 6 2018

Publication series

NameEnvironmental Arsenic in a ChangingWorld - 7th International Congress and Exhibition Arsenic in the Environment, 2018

Conference

Conference7th International Congress and Exhibition Arsenic in the Environment, 2018
CountryChina
CityBeijing
Period7/1/187/6/18

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

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