烏腳病盛行地區缺血性心臟病之病例對照研究

Translated title of the contribution: Arsenic and Ischemic Heart Disease in the Blackfoot Disease-Endemic Area

Li Ju Lin, Shan Far Horng, Kun-Fu Liaw, Yu-Mei Hsueh, Hung-Yi Chiou, Ming-His Chiang, Tung-Yuan Tai, Chin Hsiao Tseng, Chien Jen Chen

Research output: Contribution to journalArticle

Abstract

Arsenic-induced atherogenicity has been well documented. Morbidity of ischemic heart disease was examined among residents in the blackfoot disease-endemic area in southwestern Taiwan to explore the relationship between long-term arsenic exposure and ischemic heart disease. A total of 78 prevalent cases of electrocardiogram-diagnosed ischemic heart disease identified from a community-based surrey and 384 age-sex-matched healthy controls were included. Multiple logistic regression analysis showed a statistically significant association of ischemic heart disease with long-term arsenic exposure. After adjustment for age, sex, hypertension, diabetes mellitus, ratio of total cholesterol to high-density lipoprotein cholesterol, body mass index, and alcohol consumption, the odds ratio of developing ischemic heart disease was 1.60 and 3.60, respectively, for those who had a cumulative arsenic exposure of 0.1-14.9 and >=15.0ppm-years compared with those who had no exposure to arsenic through drinking water. Arsenic is an important and independent risk factor for ischemic heart disease in the blackfoot disease-endemic area.
Original languageTraditional Chinese
Pages (from-to)502-511
Number of pages10
JournalChinese Journal of Public Health
Volume14
Issue number6
Publication statusPublished - Dec 1 1995

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Keywords

  • 缺血性心臟病
  • 病例對照研究
  • Arsenic
  • Ischemic Heart Disease
  • Case-Control Study

Cite this

Lin, L. J., Horng, S. F., Liaw, K-F., Hsueh, Y-M., Chiou, H-Y., Chiang, M-H., Tai, T-Y., Tseng, C. H., & Chen, C. J. (1995). 烏腳病盛行地區缺血性心臟病之病例對照研究. Chinese Journal of Public Health, 14(6), 502-511.