Abstract
Long-term exposure to ingested arsenic from drinking water has been well documented to be associated with an increased risk of diabetes mellitus and hypertension in a dose-response relationship among residents of arseniasis-endemic areas in southwestern Taiwan and Bangladesh. An increased risk of self-reported hypertension but not diabetes was reported in a community-based study of residents who consumed drinking water with a low level of arsenic. Increased glycosylated hemoglobin level and systolic blood pressure were observed in workers occupationally exposed to arsenic. Inconsistent findings of arsenic and diabetes in occupational studies may result from the healthy worker effect and the variation in exposure measurement, age composition, number of patients, accuracy in diagnosis and classification of underlying causes of death, competing causes of death, and method to detect diabetes. The dose-response relationship and toxicological mechanisms of arsenic-induced diabetes and hypertension need further elucidation.
| Original language | English |
|---|---|
| Pages (from-to) | 298-304 |
| Number of pages | 7 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 222 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 1 2007 |
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Keywords
- Arsenic
- Diabetes mellitus
- Dose-response relationship
- Human populations
- Hypertension
ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Arsenic and diabetes and hypertension in human populations : A review. / Chen, Chien Jen; Wang, Shu Li; Chiou, Jeng Min; Tseng, Chin Hsiao; Chiou, Hung Yi; Hsueh, Yu Mei; Chen, Shu Yuan; Wu, Meei Maan; Lai, Mei Shu.
In: Toxicology and Applied Pharmacology, Vol. 222, No. 3, 01.08.2007, p. 298-304.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Arsenic and diabetes and hypertension in human populations
T2 - A review
AU - Chen, Chien Jen
AU - Wang, Shu Li
AU - Chiou, Jeng Min
AU - Tseng, Chin Hsiao
AU - Chiou, Hung Yi
AU - Hsueh, Yu Mei
AU - Chen, Shu Yuan
AU - Wu, Meei Maan
AU - Lai, Mei Shu
PY - 2007/8/1
Y1 - 2007/8/1
N2 - Long-term exposure to ingested arsenic from drinking water has been well documented to be associated with an increased risk of diabetes mellitus and hypertension in a dose-response relationship among residents of arseniasis-endemic areas in southwestern Taiwan and Bangladesh. An increased risk of self-reported hypertension but not diabetes was reported in a community-based study of residents who consumed drinking water with a low level of arsenic. Increased glycosylated hemoglobin level and systolic blood pressure were observed in workers occupationally exposed to arsenic. Inconsistent findings of arsenic and diabetes in occupational studies may result from the healthy worker effect and the variation in exposure measurement, age composition, number of patients, accuracy in diagnosis and classification of underlying causes of death, competing causes of death, and method to detect diabetes. The dose-response relationship and toxicological mechanisms of arsenic-induced diabetes and hypertension need further elucidation.
AB - Long-term exposure to ingested arsenic from drinking water has been well documented to be associated with an increased risk of diabetes mellitus and hypertension in a dose-response relationship among residents of arseniasis-endemic areas in southwestern Taiwan and Bangladesh. An increased risk of self-reported hypertension but not diabetes was reported in a community-based study of residents who consumed drinking water with a low level of arsenic. Increased glycosylated hemoglobin level and systolic blood pressure were observed in workers occupationally exposed to arsenic. Inconsistent findings of arsenic and diabetes in occupational studies may result from the healthy worker effect and the variation in exposure measurement, age composition, number of patients, accuracy in diagnosis and classification of underlying causes of death, competing causes of death, and method to detect diabetes. The dose-response relationship and toxicological mechanisms of arsenic-induced diabetes and hypertension need further elucidation.
KW - Arsenic
KW - Diabetes mellitus
KW - Dose-response relationship
KW - Human populations
KW - Hypertension
KW - Arsenic
KW - Diabetes mellitus
KW - Dose-response relationship
KW - Human populations
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=34547571754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547571754&partnerID=8YFLogxK
U2 - 10.1016/j.taap.2006.12.032
DO - 10.1016/j.taap.2006.12.032
M3 - Article
VL - 222
SP - 298
EP - 304
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 3
ER -