Aristolochic acid-induced accumulation of methylglyoxal and N ε-(carboxymethyl)lysine

An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy

Yi Chieh Li, Shin Han Tsai, Shih Ming Chen, Ya Min Chang, Tzu Chuan Huang, Yu Ping Huang, Chen Tien Chang, Jen Ai Lee

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19 Citations (Scopus)

Abstract

Aristolochic acid, found in the Aristolochia species, causes aristolochic acid nephropathy (AAN) and can develop into renal failure. Methylglyoxal (MGO) is a highly cytotoxic compound generated from the metabolic process of glucose or fatty acids. It binds to proteins and forms N ε-(carboxymethyl)lysine (CML), which contributes to aging and diabetes mellitus complications. However, no relevant literature explores the relationship of MGO and CML with AAN. By injecting AA (10mg/kg BW) into C3H/He mice for 5 consecutive days, we successfully developed an AAN model and observed tubular atrophy with decreased renal function. Creatinine clearance also decreased from 10.32±0.79ml/min/kg to 2.19±0.29ml/min/kg (p

Original languageEnglish
Pages (from-to)832-837
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume423
Issue number4
DOIs
Publication statusPublished - Jul 13 2012

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Pyruvaldehyde
Aristolochia
Inbred C3H Mouse
Diabetes Complications
Medical problems
Atrophy
Renal Insufficiency
Creatinine
Fatty Acids
Aging of materials
Kidney
Glucose
aristolochic acid I
N(6)-carboxymethyllysine
Proteins

Keywords

  • Advanced glycation end products
  • Aristolochic acid
  • Aristolochic acid nephropathy
  • Glutathione
  • Methylglyoxal
  • N -(carboxymethyl)lysine

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

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title = "Aristolochic acid-induced accumulation of methylglyoxal and N ε-(carboxymethyl)lysine: An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy",
abstract = "Aristolochic acid, found in the Aristolochia species, causes aristolochic acid nephropathy (AAN) and can develop into renal failure. Methylglyoxal (MGO) is a highly cytotoxic compound generated from the metabolic process of glucose or fatty acids. It binds to proteins and forms N ε-(carboxymethyl)lysine (CML), which contributes to aging and diabetes mellitus complications. However, no relevant literature explores the relationship of MGO and CML with AAN. By injecting AA (10mg/kg BW) into C3H/He mice for 5 consecutive days, we successfully developed an AAN model and observed tubular atrophy with decreased renal function. Creatinine clearance also decreased from 10.32±0.79ml/min/kg to 2.19±0.29ml/min/kg (p",
keywords = "Advanced glycation end products, Aristolochic acid, Aristolochic acid nephropathy, Glutathione, Methylglyoxal, N -(carboxymethyl)lysine",
author = "Li, {Yi Chieh} and Tsai, {Shin Han} and Chen, {Shih Ming} and Chang, {Ya Min} and Huang, {Tzu Chuan} and Huang, {Yu Ping} and Chang, {Chen Tien} and Lee, {Jen Ai}",
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T1 - Aristolochic acid-induced accumulation of methylglyoxal and N ε-(carboxymethyl)lysine

T2 - An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy

AU - Li, Yi Chieh

AU - Tsai, Shin Han

AU - Chen, Shih Ming

AU - Chang, Ya Min

AU - Huang, Tzu Chuan

AU - Huang, Yu Ping

AU - Chang, Chen Tien

AU - Lee, Jen Ai

PY - 2012/7/13

Y1 - 2012/7/13

N2 - Aristolochic acid, found in the Aristolochia species, causes aristolochic acid nephropathy (AAN) and can develop into renal failure. Methylglyoxal (MGO) is a highly cytotoxic compound generated from the metabolic process of glucose or fatty acids. It binds to proteins and forms N ε-(carboxymethyl)lysine (CML), which contributes to aging and diabetes mellitus complications. However, no relevant literature explores the relationship of MGO and CML with AAN. By injecting AA (10mg/kg BW) into C3H/He mice for 5 consecutive days, we successfully developed an AAN model and observed tubular atrophy with decreased renal function. Creatinine clearance also decreased from 10.32±0.79ml/min/kg to 2.19±0.29ml/min/kg (p

AB - Aristolochic acid, found in the Aristolochia species, causes aristolochic acid nephropathy (AAN) and can develop into renal failure. Methylglyoxal (MGO) is a highly cytotoxic compound generated from the metabolic process of glucose or fatty acids. It binds to proteins and forms N ε-(carboxymethyl)lysine (CML), which contributes to aging and diabetes mellitus complications. However, no relevant literature explores the relationship of MGO and CML with AAN. By injecting AA (10mg/kg BW) into C3H/He mice for 5 consecutive days, we successfully developed an AAN model and observed tubular atrophy with decreased renal function. Creatinine clearance also decreased from 10.32±0.79ml/min/kg to 2.19±0.29ml/min/kg (p

KW - Advanced glycation end products

KW - Aristolochic acid

KW - Aristolochic acid nephropathy

KW - Glutathione

KW - Methylglyoxal

KW - N -(carboxymethyl)lysine

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