Arginine methylation regulates the p53 response

Martin Jansson, Stephen T. Durant, Er Chieh Cho, Sharon Sheahan, Mariola Edelmann, Benedikt Kessler, Nicholas B. La Thangue

Research output: Contribution to journalArticle

256 Citations (Scopus)

Abstract

Activation of the p53 tumour suppressor protein in response to DNA damage leads to apoptosis or cell-cycle arrest. Enzymatic modifications are widely believed to affect and regulate p53 activity. We describe here a level of post-translational control that has an important functional consequence on the p53 response. We show that the protein arginine methyltransferase (PRMT) 5, as a co-factor in a DNA damage responsive co-activator complex that interacts with p53, is responsible for methylating p53. Arginine methylation is regulated during the p53 response and affects the target gene specificity of p53. Furthermore, PRMT5 depletion triggers p53-dependent apoptosis. Thus, methylation on arginine residues is an underlying mechanism of control during the p53 response.

Original languageEnglish
Pages (from-to)1431-1439
Number of pages9
JournalNature cell biology.
Volume10
Issue number12
DOIs
Publication statusPublished - 2008
Externally publishedYes

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Methylation
DNA Damage
Arginine
Protein-Arginine N-Methyltransferases
Apoptosis
Tumor Suppressor Protein p53
p53 Genes
Cell Cycle Checkpoints

ASJC Scopus subject areas

  • Cell Biology

Cite this

Jansson, M., Durant, S. T., Cho, E. C., Sheahan, S., Edelmann, M., Kessler, B., & La Thangue, N. B. (2008). Arginine methylation regulates the p53 response. Nature cell biology., 10(12), 1431-1439. https://doi.org/10.1038/ncb1802

Arginine methylation regulates the p53 response. / Jansson, Martin; Durant, Stephen T.; Cho, Er Chieh; Sheahan, Sharon; Edelmann, Mariola; Kessler, Benedikt; La Thangue, Nicholas B.

In: Nature cell biology., Vol. 10, No. 12, 2008, p. 1431-1439.

Research output: Contribution to journalArticle

Jansson, M, Durant, ST, Cho, EC, Sheahan, S, Edelmann, M, Kessler, B & La Thangue, NB 2008, 'Arginine methylation regulates the p53 response', Nature cell biology., vol. 10, no. 12, pp. 1431-1439. https://doi.org/10.1038/ncb1802
Jansson M, Durant ST, Cho EC, Sheahan S, Edelmann M, Kessler B et al. Arginine methylation regulates the p53 response. Nature cell biology. 2008;10(12):1431-1439. https://doi.org/10.1038/ncb1802
Jansson, Martin ; Durant, Stephen T. ; Cho, Er Chieh ; Sheahan, Sharon ; Edelmann, Mariola ; Kessler, Benedikt ; La Thangue, Nicholas B. / Arginine methylation regulates the p53 response. In: Nature cell biology. 2008 ; Vol. 10, No. 12. pp. 1431-1439.
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