Areca nut (AN, Areca catechu L.) is a popular but carcinogenic chewing material used by approximately 200-600 million people worldwide. In the past few decades, AN has been discovered to possess genotoxic, cytostatic, and cytotoxic effects on cells. Some ingredients of AN, such as AN extract (ANE), arecoline, hydroxychavicol, and oligomeric procyanidins were demonstrated to stimulate apoptotic and/or growth arresting phenotypes in treated cells. However, our recent studies showed that ANE predominantly induces the autophagic responses, albeit the simultaneous initiation of apoptotic pathway. This finding may renew the knowledge about the cytotoxic effects of AN on oral cells in physiological conditions.
|Title of host publication||Nuts: Properties, Consumption and Nutrition|
|Publisher||Nova Science Publishers Inc|
|Number of pages||6|
|Publication status||Published - 2011|
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)