Are auditory hallucinations related to the brain's resting state activity? A 'neurophenomenal resting state hypothesis'

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21 Citations (Scopus)

Abstract

While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenal, i.e., subjective-experiential features as explored in phenomenological accounts. Therefore I speak of a 'neurophenomenal resting state hypothesis' of auditory hallucinations in schizophrenia. Copyright© 2014, Korean College of Neuropsychopharmacology
Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalClinical Psychopharmacology and Neuroscience
Volume12
Issue number3
DOIs
Publication statusPublished - 2014

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Hallucinations
Auditory Cortex
Brain
Schizophrenia

Keywords

  • Auditory cortex
  • Hallucinations
  • Intrinsic activity
  • Schizophrenia
  • Article
  • auditory cortex
  • auditory hallucination
  • brain depth stimulation
  • brain mapping
  • default mode network
  • human
  • neuromodulation
  • resting state network

Cite this

@article{aa9c16af80024584baacd06fefd45e2b,
title = "Are auditory hallucinations related to the brain's resting state activity? A 'neurophenomenal resting state hypothesis'",
abstract = "While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenal, i.e., subjective-experiential features as explored in phenomenological accounts. Therefore I speak of a 'neurophenomenal resting state hypothesis' of auditory hallucinations in schizophrenia. Copyright{\circledC} 2014, Korean College of Neuropsychopharmacology",
keywords = "Auditory cortex, Hallucinations, Intrinsic activity, Schizophrenia, Article, auditory cortex, auditory hallucination, brain depth stimulation, brain mapping, default mode network, human, neuromodulation, resting state network",
author = "Northoff, {Georg Franz Josef}",
note = "Cited By :3 Export Date: 11 May 2016 Correspondence Address: Northoff, G.; Research Unit Director, Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research (IMHR), 1145 Carling Avenue, Canada Funding Details: CIHR, Canadian Institutes of Health Research References: Javitt, D.C., When doors of perception close: Bottom-up models of disrupted cognition in schizophrenia (2009) Annu Rev Clin Psychol, 5, pp. 249-275; Langdon, R., Jones, S.R., Connaughton, E., Fernyhough, C., The phenomenology of inner speech: Comparison of schizophrenia patients with auditory verbal hallucinations and healthy controls (2009) Psychol Med, 39, pp. 655-663; Jones, S.R., Do we need multiple models of auditory verbal hallucinations? Examining the phenomenological fit of cognitive and neurological models (2010) Schizophr Bull, 36, pp. 566-575; Allen, P., Laroi, F., McGuire, P.K., Aleman, A., The hallucinating brain: A review of structural and functional neuroimaging studies of hallucinations (2008) Neurosci Biobehav Rev, 32, pp. 175-191; Fletcher, P.C., Frith, C.D., Perceiving is believing: A Bayesian approach to explaining the positive symptoms of schizophrenia (2009) Nat Rev Neurosci, 10, pp. 48-58; Hugdahl, K., {"}Hearing voices{"}: Auditory hallucinations as failure of top-down control of bottom-up perceptual processes (2009) Scand J Psychol, 50, pp. 553-560; Hoffman, R.E., A social deafferentation hypothesis for induction of active schizophrenia (2007) Schizophr Bull, 33, pp. 1066-1070; Hoffman, R.E., Auditory/Verbal hallucinations, speech perception neurocircuitry, and the social deafferentation hypothesis (2008) Clin EEG Neurosci, 39, pp. 87-90; Buckner, R.L., Andrews-Hanna, J.R., Schacter, D.L., The brain's default network: Anatomy, function, and relevance to disease (2008) Ann N Y Acad Sci, 1124, pp. 1-38; Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., Shulman, G.L., A default mode of brain function (2001) Proc Natl Acad Sci U S A, 98, pp. 676-682; Northoff, G., Qin, P., Nakao, T., Rest-stimulus interaction in the brain: A review (2010) Trends Neurosci, 33, pp. 277-284; Northoff, G., Unlocking the brain (2014) Volume I: Coding, , New York:Oxford University Press; Northoff, G., Unlocking the brain (2014) Volume II: Consciousness, , New York: Oxford:Oxford University Press; Hunter, M.D., Eickhoff, S.B., Miller, T.W., Farrow, T.F., Wilkinson, I.D., Woodruff, P.W., Neural activity in speech-sensitive auditory cortex during silence (2006) Proc Natl Acad Sci U S A, 103, pp. 189-194; Dierks, T., Linden, D.E., Jandl, M., Formisano, E., Goebel, R., Lanfermann, H., Activation of Heschl's gyrus during auditory hallucinations (1999) Neuron, 22, pp. 615-621; Diederen, K.M., Van Lutterveld, R., Sommer, I.E., Neuroimaging of voice hearing in non-psychotic individuals: A mini review (2012) Front Hum Neurosci, 6, p. 111; Ford, J.M., Dierks, T., Fisher, D.J., Herrmann, C.S., Hubl, D., Kindler, J., Neurophysiological studies of auditory verbal hallucinations (2012) Schizophr Bull, 38, pp. 715-723; Northoff, G., Qin, P., How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations (2011) Schizophr Res, 127, pp. 202-214; Waters, F., Woodward, T., Allen, P., Aleman, A., Sommer, I., Self-recognition deficits in schizophrenia patients with auditory hallucinations: A meta-analysis of the literature (2012) Schizophr Bull, 38, pp. 741-750; Liddle, P.F., Regional brain abnormalities associated with specific syndromes of persistent schizophrenic symptoms (1992) Clin Neuropharmacol, 15 (Part A), pp. 401A-402A; Gur, R.E., Mozley, P.D., Resnick, S.M., Mozley, L.H., Shtasel, D.L., Gallacher, F., Resting cerebral glucose metabolism in first-episode and previously treated patients with schizophrenia relates to clinical features (1995) Arch Gen Psychiatry, 52, pp. 657-667; Homan, P., Kindler, J., Hauf, M., Walther, S., Hubl, D., Dierks, T., Repeated measurements of cerebral blood flow in the left superior temporal gyrus reveal tonic hyperactivity in patients with auditory verbal hallucinations: A possible trait marker (2013) Front Hum Neurosci, 7, p. 304; Diederen, K.M., Neggers, S.F., De Weijer, A.D., Van Lutterveld, R., Daalman, K., Eickhoff, S.B., Aberrant resting-state connectivity in non-psychotic individuals with auditory hallucinations (2013) Psychol Med, 43, pp. 1685-1696; Sommer, I.E., Clos, M., Meijering, A.L., Diederen, K.M., Eickhoff, S.B., Resting state functional connectivity in patients with chronic hallucinations (2012) PLoS One, 7; Shin, S.E., Lee, J.S., Kang, M.H., Kim, C.E., Bae, J.N., Jung, G., Segmented volumes of cerebrum and cerebellum in first episode schizophrenia with auditory hallucinations (2005) Psychiatry Res, 138, pp. 33-42; Wolf, N.D., Sambataro, F., Vasic, N., Frasch, K., Schmid, M., Sch{\"o}nfeldt-Lecuona, C., Dysconnectivity of multiple resting-state networks in patients with schizophrenia who have persistent auditory verbal hallucinations (2011) J Psychiatry Neurosci, 36, pp. 366-374; Whitfield-Gabrieli, S., Thermenos, H.W., Milanovic, S., Tsuang, M.T., Faraone, S.V., McCarley, R.W., Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia (2009) Proc Natl Acad Sci U S A, 106, pp. 1279-1284; Rotarska-Jagiela, A., Van De Ven, V., Oertel-Kn{\"o}chel, V., Uhlhaas, P.J., Vogeley, K., Linden, D.E., Resting-state functional network correlates of psychotic symptoms in schizophrenia (2010) Schizophr Res, 117, pp. 21-30; Karbasforoushan, H., Woodward, N.D., Resting-state networks in schizophrenia (2012) Curr Top Med Chem, 12, pp. 2404-2414; Yu, Q., Allen, E.A., Sui, J., Arbabshirani, M.R., Pearlson, G., Calhoun, V.D., Brain connectivity networks in schizophrenia underlying resting state functional magnetic resonance imaging (2012) Curr Top Med Chem, 12, pp. 2415-2425; Hoptman, M.J., Zuo, X.N., Butler, P.D., Javitt, D.C., D'Angelo, D., Mauro, C.J., Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study (2010) Schizophr Res, 117, pp. 13-20; Liu, H., Kaneko, Y., Ouyang, X., Li, L., Hao, Y., Chen, E.Y., Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network (2012) Schizophr Bull, 38, pp. 285-294; Northoff, G., Bermpohl, F., Cortical midline structures and the self (2004) Trends Cogn Sci, 8, pp. 102-107; Carhart-Harris, R.L., Leech, R., Erritzoe, D., Williams, T.M., Stone, J.M., Evans, J., Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis (2013) Schizophr Bull, 39, pp. 1343-1351; Enzi, B., De Greck, M., Pr{\"o}sch, U., Tempelmann, C., Northoff, G., Is our self nothing but reward? Neuronal overlap and distinction between reward and personal relevance and its relation to human personality (2009) PLoS One, 4; Northoff, G., Heinzel, A., De Greck, M., Bermpohl, F., Dobrowolny, H., Panksepp, J., Self-referential processing in our brain - A meta-analysis of imaging studies on the self (2006) Neuroimage, 31, pp. 440-457; Qin, P., Northoff, G., How is our self related to midline regions and the default-mode network? (2011) Neuroimage, 57, pp. 1221-1233; Whitfield-Gabrieli, S., Moran, J.M., Nieto-Casta{\~n}{\'o}n, A., Triantafyllou, C., Saxe, R., Gabrieli, J.D., Associations and dissociations between default and self-reference networks in the human brain (2011) Neuroimage, 55, pp. 225-232; Gawęda L, Woodward TS, Moritz S, Kokoszka A. Impaired action self-monitoring in schizophrenia patients with auditory hallucinations (2013) Schizophr Res, 144, pp. 72-79; Ford, J.M., Roach, B.J., Jorgensen, K.W., Turner, J.A., Brown, G.G., Notestine, R., Tuning in to the voices: A multisite FMRI study of auditory hallucinations (2009) Schizophr Bull, 35, pp. 58-66; Smith, D.M., Grant, B., Fisher, D.J., Borracci, G., Labelle, A., Knott, V.J., Auditory verbal hallucinations in schizophrenia correlate with P50 gating (2013) Clin Neurophysiol, 124, pp. 1329-1335; Shergill, S.S., Brammer, M.J., Amaro, E., Williams, S.C., Murray, R.M., McGuire, P.K., Temporal course of auditory hallucinations (2004) Br J Psychiatry, 185, pp. 516-517; Shergill, S.S., Bullmore, E., Simmons, A., Murray, R., McGuire, P., Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations (2000) Am J Psychiatry, 157, pp. 1691-1693; Hoffman, R.E., Anderson, A.W., Varanko, M., Gore, J.C., Hampson, M., Time course of regional brain activation associated with onset of auditory/verbal hallucinations (2008) Br J Psychiatry, 193, pp. 424-425; Van De Ven, V.G., Formisano, E., R{\"o}der, C.H., Prvulovic, D., Bittner, R.A., Dietz, M.G., The spatiotemporal pattern of auditory cortical responses during verbal hallucinations (2005) Neuroimage, 27, pp. 644-655; Hoffman, R.E., Hampson, M., Wu, K., Anderson, A.W., Gore, J.C., Buchanan, R.J., Probing the pathophysiology of auditory/verbal hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation (2007) Cereb Cortex, 17, pp. 2733-2743; Mechelli, A., Allen, P., Amaro, E., Jr., Fu, C.H., Williams, S.C., Brammer, M.J., Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations (2007) Hum Brain Mapp, 28, pp. 1213-1222; Raij, T.T., Valkonen-Korhonen, M., Holi, M., Therman, S., Lehtonen, J., Hari, R., Reality of auditory verbal hallucinations (2009) Brain, 132, pp. 2994-3001; Blankenburg, W., Approach to the psychopathology of common sense (1969) Confin Psychiatr, 12, pp. 144-163; Lysaker, P., Lysaker, J., (2008) Schizophrenia and the Fate of the Self, , New York:Oxford University Press; Minkowski, E., The essential disorder underlying schizophrenia and schizophrenic thought (1987) The Clinical Roots of the Schizophrenia Concept: Translations of Seminal European Contributions on Schizophrenia. Orignal Work Published 1927, , Cutting J, Shepherd M, editors. New York:Cambridge University Press; Parnas, J., Self and schizophrenia: A phenomenological perspective (2003) The Self in Neuroscience and Psychiatry, , Kircher T, David AS, editors. New York:Cambridge University Press; Parnas, J., Handest, P., Phenomenology of anomalous self-experience in early schizophrenia (2003) Compr Psychiatry, 44, pp. 121-134; Parnas, J., Raballo, A., Handest, P., Jansson, L., Voller-Larsen, A., Saetbye, D., Self-experience in the early prodromal phases of schizophrenia. 5-year follow-up of the Copenhagen Prodromal study (2011) World Psychiatry, 10, pp. 200-204; Sass, L.A., Schizophrenia, self-experience, and the so-called 'negative symptoms' (2000) Exploring the Self: Philosophical and Psychopathological Perspectives on Self-experience, , Zahavi D, editor. Amsterdam:John Benjamins Pub; Sass, L.A., Self-disturbance in schizophrenia: Hyperreflexivity and diminished (2003) The Self in Neuroscience and Psychiatry, , Kircher T, David AS, editors. New York:Cambridge University Press; Sass, L.A., Parnas, J., Phenomenology of self disturbances in schizophrenia: Some research findings and directions (2001) Philos Psychiatry Psychol, 8, pp. 347-356; Sass, L.A., Kircher, T., David, A., Self-disturbance in schizophrenia: Hyperreflexivity and diminished self-affection (2003) The Self in Neuroscience and Psychiatry, , Kircher T, editor. New York:Cambridge University Press; No. 870539117; Bin Kimura, B., The self and its time (1997) Evol Psychiatr, 62, pp. 225-348; Parnas, J., Handest, P., Saebye, D., Jansson, L., Anomalies of subjective experience in schizophrenia and psychotic bipolar illness (2003) Acta Psychiatr Scand, 108, pp. 126-133; Sass, L., Schizophrenia, self-experience, and the so-called negative symptoms (2000) Exploring the Self: Philosophical and Psychopathological Perspectives on Self-experience, pp. 149-182. , Zahavi D, editor. Amsterdam:John Benjamins Pub",
year = "2014",
doi = "10.9758/cpn.2014.12.3.189",
language = "English",
volume = "12",
pages = "189--195",
journal = "Clinical Psychopharmacology and Neuroscience",
issn = "1738-1088",
publisher = "Korean College of Neuropsychopharmacology",
number = "3",

}

TY - JOUR

T1 - Are auditory hallucinations related to the brain's resting state activity? A 'neurophenomenal resting state hypothesis'

AU - Northoff, Georg Franz Josef

N1 - Cited By :3 Export Date: 11 May 2016 Correspondence Address: Northoff, G.; Research Unit Director, Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research (IMHR), 1145 Carling Avenue, Canada Funding Details: CIHR, Canadian Institutes of Health Research References: Javitt, D.C., When doors of perception close: Bottom-up models of disrupted cognition in schizophrenia (2009) Annu Rev Clin Psychol, 5, pp. 249-275; Langdon, R., Jones, S.R., Connaughton, E., Fernyhough, C., The phenomenology of inner speech: Comparison of schizophrenia patients with auditory verbal hallucinations and healthy controls (2009) Psychol Med, 39, pp. 655-663; Jones, S.R., Do we need multiple models of auditory verbal hallucinations? Examining the phenomenological fit of cognitive and neurological models (2010) Schizophr Bull, 36, pp. 566-575; Allen, P., Laroi, F., McGuire, P.K., Aleman, A., The hallucinating brain: A review of structural and functional neuroimaging studies of hallucinations (2008) Neurosci Biobehav Rev, 32, pp. 175-191; Fletcher, P.C., Frith, C.D., Perceiving is believing: A Bayesian approach to explaining the positive symptoms of schizophrenia (2009) Nat Rev Neurosci, 10, pp. 48-58; Hugdahl, K., "Hearing voices": Auditory hallucinations as failure of top-down control of bottom-up perceptual processes (2009) Scand J Psychol, 50, pp. 553-560; Hoffman, R.E., A social deafferentation hypothesis for induction of active schizophrenia (2007) Schizophr Bull, 33, pp. 1066-1070; Hoffman, R.E., Auditory/Verbal hallucinations, speech perception neurocircuitry, and the social deafferentation hypothesis (2008) Clin EEG Neurosci, 39, pp. 87-90; Buckner, R.L., Andrews-Hanna, J.R., Schacter, D.L., The brain's default network: Anatomy, function, and relevance to disease (2008) Ann N Y Acad Sci, 1124, pp. 1-38; Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., Shulman, G.L., A default mode of brain function (2001) Proc Natl Acad Sci U S A, 98, pp. 676-682; Northoff, G., Qin, P., Nakao, T., Rest-stimulus interaction in the brain: A review (2010) Trends Neurosci, 33, pp. 277-284; Northoff, G., Unlocking the brain (2014) Volume I: Coding, , New York:Oxford University Press; Northoff, G., Unlocking the brain (2014) Volume II: Consciousness, , New York: Oxford:Oxford University Press; Hunter, M.D., Eickhoff, S.B., Miller, T.W., Farrow, T.F., Wilkinson, I.D., Woodruff, P.W., Neural activity in speech-sensitive auditory cortex during silence (2006) Proc Natl Acad Sci U S A, 103, pp. 189-194; Dierks, T., Linden, D.E., Jandl, M., Formisano, E., Goebel, R., Lanfermann, H., Activation of Heschl's gyrus during auditory hallucinations (1999) Neuron, 22, pp. 615-621; Diederen, K.M., Van Lutterveld, R., Sommer, I.E., Neuroimaging of voice hearing in non-psychotic individuals: A mini review (2012) Front Hum Neurosci, 6, p. 111; Ford, J.M., Dierks, T., Fisher, D.J., Herrmann, C.S., Hubl, D., Kindler, J., Neurophysiological studies of auditory verbal hallucinations (2012) Schizophr Bull, 38, pp. 715-723; Northoff, G., Qin, P., How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations (2011) Schizophr Res, 127, pp. 202-214; Waters, F., Woodward, T., Allen, P., Aleman, A., Sommer, I., Self-recognition deficits in schizophrenia patients with auditory hallucinations: A meta-analysis of the literature (2012) Schizophr Bull, 38, pp. 741-750; Liddle, P.F., Regional brain abnormalities associated with specific syndromes of persistent schizophrenic symptoms (1992) Clin Neuropharmacol, 15 (Part A), pp. 401A-402A; Gur, R.E., Mozley, P.D., Resnick, S.M., Mozley, L.H., Shtasel, D.L., Gallacher, F., Resting cerebral glucose metabolism in first-episode and previously treated patients with schizophrenia relates to clinical features (1995) Arch Gen Psychiatry, 52, pp. 657-667; Homan, P., Kindler, J., Hauf, M., Walther, S., Hubl, D., Dierks, T., Repeated measurements of cerebral blood flow in the left superior temporal gyrus reveal tonic hyperactivity in patients with auditory verbal hallucinations: A possible trait marker (2013) Front Hum Neurosci, 7, p. 304; Diederen, K.M., Neggers, S.F., De Weijer, A.D., Van Lutterveld, R., Daalman, K., Eickhoff, S.B., Aberrant resting-state connectivity in non-psychotic individuals with auditory hallucinations (2013) Psychol Med, 43, pp. 1685-1696; Sommer, I.E., Clos, M., Meijering, A.L., Diederen, K.M., Eickhoff, S.B., Resting state functional connectivity in patients with chronic hallucinations (2012) PLoS One, 7; Shin, S.E., Lee, J.S., Kang, M.H., Kim, C.E., Bae, J.N., Jung, G., Segmented volumes of cerebrum and cerebellum in first episode schizophrenia with auditory hallucinations (2005) Psychiatry Res, 138, pp. 33-42; Wolf, N.D., Sambataro, F., Vasic, N., Frasch, K., Schmid, M., Schönfeldt-Lecuona, C., Dysconnectivity of multiple resting-state networks in patients with schizophrenia who have persistent auditory verbal hallucinations (2011) J Psychiatry Neurosci, 36, pp. 366-374; Whitfield-Gabrieli, S., Thermenos, H.W., Milanovic, S., Tsuang, M.T., Faraone, S.V., McCarley, R.W., Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia (2009) Proc Natl Acad Sci U S A, 106, pp. 1279-1284; Rotarska-Jagiela, A., Van De Ven, V., Oertel-Knöchel, V., Uhlhaas, P.J., Vogeley, K., Linden, D.E., Resting-state functional network correlates of psychotic symptoms in schizophrenia (2010) Schizophr Res, 117, pp. 21-30; Karbasforoushan, H., Woodward, N.D., Resting-state networks in schizophrenia (2012) Curr Top Med Chem, 12, pp. 2404-2414; Yu, Q., Allen, E.A., Sui, J., Arbabshirani, M.R., Pearlson, G., Calhoun, V.D., Brain connectivity networks in schizophrenia underlying resting state functional magnetic resonance imaging (2012) Curr Top Med Chem, 12, pp. 2415-2425; Hoptman, M.J., Zuo, X.N., Butler, P.D., Javitt, D.C., D'Angelo, D., Mauro, C.J., Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study (2010) Schizophr Res, 117, pp. 13-20; Liu, H., Kaneko, Y., Ouyang, X., Li, L., Hao, Y., Chen, E.Y., Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network (2012) Schizophr Bull, 38, pp. 285-294; Northoff, G., Bermpohl, F., Cortical midline structures and the self (2004) Trends Cogn Sci, 8, pp. 102-107; Carhart-Harris, R.L., Leech, R., Erritzoe, D., Williams, T.M., Stone, J.M., Evans, J., Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis (2013) Schizophr Bull, 39, pp. 1343-1351; Enzi, B., De Greck, M., Prösch, U., Tempelmann, C., Northoff, G., Is our self nothing but reward? Neuronal overlap and distinction between reward and personal relevance and its relation to human personality (2009) PLoS One, 4; Northoff, G., Heinzel, A., De Greck, M., Bermpohl, F., Dobrowolny, H., Panksepp, J., Self-referential processing in our brain - A meta-analysis of imaging studies on the self (2006) Neuroimage, 31, pp. 440-457; Qin, P., Northoff, G., How is our self related to midline regions and the default-mode network? (2011) Neuroimage, 57, pp. 1221-1233; Whitfield-Gabrieli, S., Moran, J.M., Nieto-Castañón, A., Triantafyllou, C., Saxe, R., Gabrieli, J.D., Associations and dissociations between default and self-reference networks in the human brain (2011) Neuroimage, 55, pp. 225-232; Gawęda L, Woodward TS, Moritz S, Kokoszka A. Impaired action self-monitoring in schizophrenia patients with auditory hallucinations (2013) Schizophr Res, 144, pp. 72-79; Ford, J.M., Roach, B.J., Jorgensen, K.W., Turner, J.A., Brown, G.G., Notestine, R., Tuning in to the voices: A multisite FMRI study of auditory hallucinations (2009) Schizophr Bull, 35, pp. 58-66; Smith, D.M., Grant, B., Fisher, D.J., Borracci, G., Labelle, A., Knott, V.J., Auditory verbal hallucinations in schizophrenia correlate with P50 gating (2013) Clin Neurophysiol, 124, pp. 1329-1335; Shergill, S.S., Brammer, M.J., Amaro, E., Williams, S.C., Murray, R.M., McGuire, P.K., Temporal course of auditory hallucinations (2004) Br J Psychiatry, 185, pp. 516-517; Shergill, S.S., Bullmore, E., Simmons, A., Murray, R., McGuire, P., Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations (2000) Am J Psychiatry, 157, pp. 1691-1693; Hoffman, R.E., Anderson, A.W., Varanko, M., Gore, J.C., Hampson, M., Time course of regional brain activation associated with onset of auditory/verbal hallucinations (2008) Br J Psychiatry, 193, pp. 424-425; Van De Ven, V.G., Formisano, E., Röder, C.H., Prvulovic, D., Bittner, R.A., Dietz, M.G., The spatiotemporal pattern of auditory cortical responses during verbal hallucinations (2005) Neuroimage, 27, pp. 644-655; Hoffman, R.E., Hampson, M., Wu, K., Anderson, A.W., Gore, J.C., Buchanan, R.J., Probing the pathophysiology of auditory/verbal hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation (2007) Cereb Cortex, 17, pp. 2733-2743; Mechelli, A., Allen, P., Amaro, E., Jr., Fu, C.H., Williams, S.C., Brammer, M.J., Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations (2007) Hum Brain Mapp, 28, pp. 1213-1222; Raij, T.T., Valkonen-Korhonen, M., Holi, M., Therman, S., Lehtonen, J., Hari, R., Reality of auditory verbal hallucinations (2009) Brain, 132, pp. 2994-3001; Blankenburg, W., Approach to the psychopathology of common sense (1969) Confin Psychiatr, 12, pp. 144-163; Lysaker, P., Lysaker, J., (2008) Schizophrenia and the Fate of the Self, , New York:Oxford University Press; Minkowski, E., The essential disorder underlying schizophrenia and schizophrenic thought (1987) The Clinical Roots of the Schizophrenia Concept: Translations of Seminal European Contributions on Schizophrenia. Orignal Work Published 1927, , Cutting J, Shepherd M, editors. New York:Cambridge University Press; Parnas, J., Self and schizophrenia: A phenomenological perspective (2003) The Self in Neuroscience and Psychiatry, , Kircher T, David AS, editors. New York:Cambridge University Press; Parnas, J., Handest, P., Phenomenology of anomalous self-experience in early schizophrenia (2003) Compr Psychiatry, 44, pp. 121-134; Parnas, J., Raballo, A., Handest, P., Jansson, L., Voller-Larsen, A., Saetbye, D., Self-experience in the early prodromal phases of schizophrenia. 5-year follow-up of the Copenhagen Prodromal study (2011) World Psychiatry, 10, pp. 200-204; Sass, L.A., Schizophrenia, self-experience, and the so-called 'negative symptoms' (2000) Exploring the Self: Philosophical and Psychopathological Perspectives on Self-experience, , Zahavi D, editor. Amsterdam:John Benjamins Pub; Sass, L.A., Self-disturbance in schizophrenia: Hyperreflexivity and diminished (2003) The Self in Neuroscience and Psychiatry, , Kircher T, David AS, editors. New York:Cambridge University Press; Sass, L.A., Parnas, J., Phenomenology of self disturbances in schizophrenia: Some research findings and directions (2001) Philos Psychiatry Psychol, 8, pp. 347-356; Sass, L.A., Kircher, T., David, A., Self-disturbance in schizophrenia: Hyperreflexivity and diminished self-affection (2003) The Self in Neuroscience and Psychiatry, , Kircher T, editor. New York:Cambridge University Press; No. 870539117; Bin Kimura, B., The self and its time (1997) Evol Psychiatr, 62, pp. 225-348; Parnas, J., Handest, P., Saebye, D., Jansson, L., Anomalies of subjective experience in schizophrenia and psychotic bipolar illness (2003) Acta Psychiatr Scand, 108, pp. 126-133; Sass, L., Schizophrenia, self-experience, and the so-called negative symptoms (2000) Exploring the Self: Philosophical and Psychopathological Perspectives on Self-experience, pp. 149-182. , Zahavi D, editor. Amsterdam:John Benjamins Pub

PY - 2014

Y1 - 2014

N2 - While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenal, i.e., subjective-experiential features as explored in phenomenological accounts. Therefore I speak of a 'neurophenomenal resting state hypothesis' of auditory hallucinations in schizophrenia. Copyright© 2014, Korean College of Neuropsychopharmacology

AB - While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenal, i.e., subjective-experiential features as explored in phenomenological accounts. Therefore I speak of a 'neurophenomenal resting state hypothesis' of auditory hallucinations in schizophrenia. Copyright© 2014, Korean College of Neuropsychopharmacology

KW - Auditory cortex

KW - Hallucinations

KW - Intrinsic activity

KW - Schizophrenia

KW - Article

KW - auditory cortex

KW - auditory hallucination

KW - brain depth stimulation

KW - brain mapping

KW - default mode network

KW - human

KW - neuromodulation

KW - resting state network

U2 - 10.9758/cpn.2014.12.3.189

DO - 10.9758/cpn.2014.12.3.189

M3 - Article

VL - 12

SP - 189

EP - 195

JO - Clinical Psychopharmacology and Neuroscience

JF - Clinical Psychopharmacology and Neuroscience

SN - 1738-1088

IS - 3

ER -