Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes

Wei Jern Tsai, Chu Ting Chang, Guei Jane Wang, Tzong Huei Lee, Shwu Fen Chang, Shao Chun Lu, Yuh Chi Kuo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The central event in the generation of immune responses is the activation and clonal expansion of T cells. Interaction of T cells with antigens initiates a cascade of biochemical events and gene expression that induces the resting T cells to activate and proliferate [1]. Activation of nuclear factor of activated T cells (NF-AT) and a series of genes such as interleukin-2 (IL-2) and interferon-γ (IFN-γ) are pivotal in the growth of T lymphocytes induced by antigens [2,3]. Thus, growth modulators or other external events affecting T cell proliferation are likely to act by controlling the expression or function of the products of these genes [4]. The immune responses to invasive organisms, if inappropriately intense or prolonged, may paradoxically aggravate the injury or even cause death. The use of immunomodulatory medications must therefore be discreet. Regulation of T lymphocyte activation and proliferation and cytokine production is one of the action mechanisms [5,6].

Original languageEnglish
Title of host publicationRecent Advances in Plant-Based, Traditional, and Natural Medicines
PublisherApple Academic Press
Pages111-128
Number of pages18
ISBN (Electronic)9781482243598
ISBN (Print)9781771880138
Publication statusPublished - Jan 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Tsai, W. J., Chang, C. T., Wang, G. J., Lee, T. H., Chang, S. F., Lu, S. C., & Kuo, Y. C. (2014). Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes. In Recent Advances in Plant-Based, Traditional, and Natural Medicines (pp. 111-128). Apple Academic Press.