TY - JOUR
T1 - Arabinogalactan present in the mountain celery seed extract potentiated hypolipidemic bioactivity of coexisting polyphenols in hamsters
AU - Lin, Li Yun
AU - Ker, Yaw Bee
AU - Chang, Chi Huan
AU - Chen, Kuan Chou
AU - Peng, Robert Y.
N1 - Funding Information:
The work was in part financially supported by Grant NSC 91-2626-B-241-004, NSC 96-2320-B-241-006-MY3, NSC 97-2313-B-241-007-MY3 and NSC 97-2320-B-039-049-MY3 from the National Science Council, Taiwan.
PY - 2011/3
Y1 - 2011/3
N2 - Context: Previously, we showed the essential oils (EO) of the mountain celery [Cryptotaenia japonica Hass (Umbelliferae)] seeds (MCS) to be a prominent hypolipidemic agent. Objective: We hypothesized the aqueous extract (AE) of its seeds could also exhibit a comparable nutritional effect. Materials and methods: Experiments were carried out for compositional analysis, antioxidant assay, and hypolipidaemic assay with AE in hamsters. Results: AE contained soluble arabinogalactan (AGal) with molecular weight (MW) 878 kDa. AE also was enriched in polyphenolics and flavonoids, reaching 30.4 and 2.20 mg/100g, respectively. AGal consisted of eight monosaccharides (in mols %), galactose (28.75), arabinose (24.84), glucose (17.91), mannose (6.93), ribose (6.03), fucose (5.83), xylose (5.30), and rhamnose (4.41), with average MW 878 kDa. In vitro, AE showed potent ferrous chelating and DPPH scavenging effects but only moderate H2O2 scavenging capability. In hamsters, AE exhibited promising hypolipidemic bioactivity, in particular, the HDL-C and hepatic unsaturated fatty acid (UFA) biosynthesis regarding oleic, linoleic, and arachidonic acids. Discussion and conclusion: The presence of AGal enhanced the hypolipidemic and antioxidative bioactivity of MCS. MCS is feasibly beneficial to the hepatic de novo UFA synthesis and the hypolipidemics as evidenced by hamster model.
AB - Context: Previously, we showed the essential oils (EO) of the mountain celery [Cryptotaenia japonica Hass (Umbelliferae)] seeds (MCS) to be a prominent hypolipidemic agent. Objective: We hypothesized the aqueous extract (AE) of its seeds could also exhibit a comparable nutritional effect. Materials and methods: Experiments were carried out for compositional analysis, antioxidant assay, and hypolipidaemic assay with AE in hamsters. Results: AE contained soluble arabinogalactan (AGal) with molecular weight (MW) 878 kDa. AE also was enriched in polyphenolics and flavonoids, reaching 30.4 and 2.20 mg/100g, respectively. AGal consisted of eight monosaccharides (in mols %), galactose (28.75), arabinose (24.84), glucose (17.91), mannose (6.93), ribose (6.03), fucose (5.83), xylose (5.30), and rhamnose (4.41), with average MW 878 kDa. In vitro, AE showed potent ferrous chelating and DPPH scavenging effects but only moderate H2O2 scavenging capability. In hamsters, AE exhibited promising hypolipidemic bioactivity, in particular, the HDL-C and hepatic unsaturated fatty acid (UFA) biosynthesis regarding oleic, linoleic, and arachidonic acids. Discussion and conclusion: The presence of AGal enhanced the hypolipidemic and antioxidative bioactivity of MCS. MCS is feasibly beneficial to the hepatic de novo UFA synthesis and the hypolipidemics as evidenced by hamster model.
KW - LDL-C/HDL-C
KW - aqueous extract
KW - hypolipidemic
KW - mountain celery seeds
KW - polyphenols and flavonoids
KW - polysaccharides
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U2 - 10.3109/13880209.2010.516753
DO - 10.3109/13880209.2010.516753
M3 - Article
C2 - 21323484
AN - SCOPUS:79951727786
VL - 49
SP - 319
EP - 326
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
SN - 1388-0209
IS - 3
ER -