Arabinogalactan present in the mountain celery seed extract potentiated hypolipidemic bioactivity of coexisting polyphenols in hamsters

Li Yun Lin, Yaw Bee Ker, Chi Huan Chang, Kuan Chou Chen, Robert Y. Peng

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Context: Previously, we showed the essential oils (EO) of the mountain celery [Cryptotaenia japonica Hass (Umbelliferae)] seeds (MCS) to be a prominent hypolipidemic agent. Objective: We hypothesized the aqueous extract (AE) of its seeds could also exhibit a comparable nutritional effect. Materials and methods: Experiments were carried out for compositional analysis, antioxidant assay, and hypolipidaemic assay with AE in hamsters. Results: AE contained soluble arabinogalactan (AGal) with molecular weight (MW) 878 kDa. AE also was enriched in polyphenolics and flavonoids, reaching 30.4 and 2.20 mg/100g, respectively. AGal consisted of eight monosaccharides (in mols %), galactose (28.75), arabinose (24.84), glucose (17.91), mannose (6.93), ribose (6.03), fucose (5.83), xylose (5.30), and rhamnose (4.41), with average MW 878 kDa. In vitro, AE showed potent ferrous chelating and DPPH scavenging effects but only moderate H2O2 scavenging capability. In hamsters, AE exhibited promising hypolipidemic bioactivity, in particular, the HDL-C and hepatic unsaturated fatty acid (UFA) biosynthesis regarding oleic, linoleic, and arachidonic acids. Discussion and conclusion: The presence of AGal enhanced the hypolipidemic and antioxidative bioactivity of MCS. MCS is feasibly beneficial to the hepatic de novo UFA synthesis and the hypolipidemics as evidenced by hamster model.

Original languageEnglish
Pages (from-to)319-326
Number of pages8
JournalPharmaceutical Biology
Volume49
Issue number3
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Apium graveolens
Polyphenols
Cricetinae
Seeds
Unsaturated Fatty Acids
Molecular Weight
Apiaceae
Oleic Acids
Linoleic Acids
Arachidonic Acids
Hypolipidemic Agents
Rhamnose
Arabinose
Ribose
Fucose
Monosaccharides
Xylose
Liver
Volatile Oils
Mannose

Keywords

  • aqueous extract
  • hypolipidemic
  • LDL-C/HDL-C
  • mountain celery seeds
  • polyphenols and flavonoids
  • polysaccharides

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Molecular Medicine

Cite this

Arabinogalactan present in the mountain celery seed extract potentiated hypolipidemic bioactivity of coexisting polyphenols in hamsters. / Lin, Li Yun; Ker, Yaw Bee; Chang, Chi Huan; Chen, Kuan Chou; Peng, Robert Y.

In: Pharmaceutical Biology, Vol. 49, No. 3, 03.2011, p. 319-326.

Research output: Contribution to journalArticle

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abstract = "Context: Previously, we showed the essential oils (EO) of the mountain celery [Cryptotaenia japonica Hass (Umbelliferae)] seeds (MCS) to be a prominent hypolipidemic agent. Objective: We hypothesized the aqueous extract (AE) of its seeds could also exhibit a comparable nutritional effect. Materials and methods: Experiments were carried out for compositional analysis, antioxidant assay, and hypolipidaemic assay with AE in hamsters. Results: AE contained soluble arabinogalactan (AGal) with molecular weight (MW) 878 kDa. AE also was enriched in polyphenolics and flavonoids, reaching 30.4 and 2.20 mg/100g, respectively. AGal consisted of eight monosaccharides (in mols {\%}), galactose (28.75), arabinose (24.84), glucose (17.91), mannose (6.93), ribose (6.03), fucose (5.83), xylose (5.30), and rhamnose (4.41), with average MW 878 kDa. In vitro, AE showed potent ferrous chelating and DPPH scavenging effects but only moderate H2O2 scavenging capability. In hamsters, AE exhibited promising hypolipidemic bioactivity, in particular, the HDL-C and hepatic unsaturated fatty acid (UFA) biosynthesis regarding oleic, linoleic, and arachidonic acids. Discussion and conclusion: The presence of AGal enhanced the hypolipidemic and antioxidative bioactivity of MCS. MCS is feasibly beneficial to the hepatic de novo UFA synthesis and the hypolipidemics as evidenced by hamster model.",
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