AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasis

JuanJuan Yin, Yen Nien Liu, Heather Tillman, Ben Barrett, Stephen Hewitt, Kris Ylaya, Lei Fang, Ross Lake, Eva Corey, Colm Morrissey, Robert Vessella, Kathleen Kelly

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The recurrence of prostate cancer metastases to bone after androgen deprivation therapy is a major clinical challenge. We identified FN14 (TNFRSF12A), a TNF receptor family member, as a factor that promotes prostate cancer bone metastasis. In experimental models, depletion of FN14 inhibited bone metastasis, and FN14 could be functionally reconstituted with IKKβ-dependent, NFκB signaling activation. In human prostate cancer, upregulated FN14 expression was observed in more than half of metastatic samples. In addition, FN14 expression was correlated inversely with androgen receptor (AR) signaling output in clinical samples. Consistent with this, AR binding to the FN14 enhancer decreased expression. We show here that FN14 may be a survival factor in low AR output prostate cancer cells. Our results define one upstream mechanism, via FN14 signaling, through which the NFκB pathway contributes to prostate cancer metastasis and suggest FN14 as a candidate therapeutic and imaging target for castrate-resistant prostate cancers.

Original languageEnglish
Pages (from-to)4306-4317
Number of pages12
JournalCancer Research
Volume74
Issue number16
DOIs
Publication statusPublished - Aug 15 2014

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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    Yin, J., Liu, Y. N., Tillman, H., Barrett, B., Hewitt, S., Ylaya, K., Fang, L., Lake, R., Corey, E., Morrissey, C., Vessella, R., & Kelly, K. (2014). AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasis. Cancer Research, 74(16), 4306-4317. https://doi.org/10.1158/0008-5472.CAN-13-3233