Aqueous synthesis of CuInZnS/ZnS quantum dots by using dual stabilizers: A targeting nanoprobe for cell imaging

Jayaraman Vinayagam, Guan Rong Chen, Ting Yi Huang, Jinn Hsuan Ho, Yong Chien Ling, Keng Liang Ou, Jia Yaw Chang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Herein, we prepared dual-stabilizer-capped CuInZnS/ZnS (CIZS/ZnS) quantum dots (QDs) in aqueous media via hydrothermal routes. On using the combination of poly (styrenesulfonic acid-co maleic acid) and glutathione stabilizers, we found that dual stabilizers effectively coat the surface of CIZS/ZnS QDs, resulting in high quantum yields and carboxylic acid groups that conjugate with various materials. To demonstrate their potential biomedical application, the dual-stabilizer-capped CIZS/ZnS QDs were conjugated with 3-aminophenylboronic acid, termed CIZS/ZnS@APBA, for HeLa tumor cell labeling. In vitro and in vivo assessments using HeLa cells and zebrafish embryos, respectively, revealed that these CIZS/ZnS@APBA nanoprobes exhibit low cytotoxicity under our experimental conditions. Confocal scanning laser imaging demonstrated that the nanoprobes can be efficiently internalized and are localized in the cytoplasm of HeLa cells. This work reveals the potential for use of CIZS/ZnS@APBA as a safe and effective targeted probe for in vivo imaging of cancer.

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalMaterials Letters
Volume173
DOIs
Publication statusPublished - Jun 15 2016

Fingerprint

Nanoprobes
Semiconductor quantum dots
quantum dots
Imaging techniques
acids
Acids
synthesis
cells
Quantum yield
Cytotoxicity
Carboxylic Acids
Carboxylic acids
Labeling
glutathione
Glutathione
cytoplasm
Tumors
embryos
Cells
carboxylic acids

Keywords

  • Cell imaging
  • Luminescence
  • Nanoparticles
  • Semiconductors

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Vinayagam, J., Chen, G. R., Huang, T. Y., Ho, J. H., Ling, Y. C., Ou, K. L., & Chang, J. Y. (2016). Aqueous synthesis of CuInZnS/ZnS quantum dots by using dual stabilizers: A targeting nanoprobe for cell imaging. Materials Letters, 173, 242-247. https://doi.org/10.1016/j.matlet.2016.03.041

Aqueous synthesis of CuInZnS/ZnS quantum dots by using dual stabilizers : A targeting nanoprobe for cell imaging. / Vinayagam, Jayaraman; Chen, Guan Rong; Huang, Ting Yi; Ho, Jinn Hsuan; Ling, Yong Chien; Ou, Keng Liang; Chang, Jia Yaw.

In: Materials Letters, Vol. 173, 15.06.2016, p. 242-247.

Research output: Contribution to journalArticle

Vinayagam, Jayaraman ; Chen, Guan Rong ; Huang, Ting Yi ; Ho, Jinn Hsuan ; Ling, Yong Chien ; Ou, Keng Liang ; Chang, Jia Yaw. / Aqueous synthesis of CuInZnS/ZnS quantum dots by using dual stabilizers : A targeting nanoprobe for cell imaging. In: Materials Letters. 2016 ; Vol. 173. pp. 242-247.
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