Aquaglyceroporin-7 overexpression in women with the polycystic ovary syndrome

Kok Min Seow, Yu Hung Lin, Peng Hui Wang, Jiann Loung Hwang, Low Tone Ho, Chi Chang Juan

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: Aquaglyceroporin-7 (AQP7) is an adipose glycerol channel protein that has been suggested to be involved in whole-body glucose homeostasis and insulin sensitivity. The aim of this study was to investigate the expression of AQP7 in visceral adipose tissues from women with the polycystic ovary syndrome (PCOS). Methods:AQP7 mRNA and protein levels were measured in omental adipose tissue from 5 women with the PCOS and 4 healthy controls matched for body mass index and age; this was done by the real-time polymerase chain reaction (PCR) and Western blotting. -Results: The women with the PCOS had significantly higher homeostasis model insulin resistance indices (HOMA IR) and their quantitative insulin sensitivity check indices were significantly lower compared to the controls (p <0.05). No significant difference was noted between the two groups for the plasma glycerol concentration. AQP7 mRNA expression and protein levels in omental adipose tissue from women with the PCOS were significantly higher than those of the controls (p = 0.007). AQP7 expression showed a positive correlation with fasting insulin levels, insulin levels at 2 h after glucose loading and HOMAIR in women with the PCOS. Conclusion:AQP7 overexpression may be related to insulin sensitivity and glucose homeostasis in women with the PCOS.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalGynecologic and Obstetric Investigation
Volume75
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Aquaporin-7
  • Insulin resistance
  • Obesity
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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