Applications of mesenchymal stem cells

An updated review

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) can be readily isolated from a number of adult and fetal tissues, and have the capacity of expansion in vitro on a clinical scale. Bone marrow MSCs are able to differentiate into multiple cell lineages that resemble osteoblasts, chondrocytes, myoblasts, adipocytes, endothelial cells, neuron-like cells, cardiomyocytes and hepatocytes. Preclinical findings from animal experiments are promising and have shown that human multipotent MSCs may have considerable therapeutic potential in a wide variety of human diseases. Research into the role that MSCs play in the induction of tolerance in bone marrow and organ transplantation holds great for future therapeutic strategies. Clinical trials are underway to assess the safety, feasibility and efficacy of MSC transplantation in a variety of human diseases. Clinicians need to know the recent progress and rationale for performing these clinical studies. As such, this review focuses on the background of MSCs and medical research in this area, bridging bench and bedside applications. Conflicting preclinical results and published data from our laboratory are discussed.

Original languageEnglish
Pages (from-to)228-236
Number of pages9
JournalChang Gung Medical Journal
Volume31
Issue number3
Publication statusPublished - May 2008
Externally publishedYes

Fingerprint

Mesenchymal Stromal Cells
Mesenchymal Stem Cell Transplantation
Multipotent Stem Cells
Stem Cell Research
Myoblasts
Organ Transplantation
Cell Lineage
Chondrocytes
Osteoblasts
Bone Marrow Transplantation
Adipocytes
Cardiac Myocytes
Biomedical Research
Hepatocytes
Fetus
Endothelial Cells
Bone Marrow
Clinical Trials
Safety
Neurons

Keywords

  • Bone marrow
  • Mesenchymal stem cell

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Applications of mesenchymal stem cells : An updated review. / Lee, Kuan Der.

In: Chang Gung Medical Journal, Vol. 31, No. 3, 05.2008, p. 228-236.

Research output: Contribution to journalReview article

@article{a6549e987b864a29b800f74123eaa09b,
title = "Applications of mesenchymal stem cells: An updated review",
abstract = "Mesenchymal stem cells (MSCs) can be readily isolated from a number of adult and fetal tissues, and have the capacity of expansion in vitro on a clinical scale. Bone marrow MSCs are able to differentiate into multiple cell lineages that resemble osteoblasts, chondrocytes, myoblasts, adipocytes, endothelial cells, neuron-like cells, cardiomyocytes and hepatocytes. Preclinical findings from animal experiments are promising and have shown that human multipotent MSCs may have considerable therapeutic potential in a wide variety of human diseases. Research into the role that MSCs play in the induction of tolerance in bone marrow and organ transplantation holds great for future therapeutic strategies. Clinical trials are underway to assess the safety, feasibility and efficacy of MSC transplantation in a variety of human diseases. Clinicians need to know the recent progress and rationale for performing these clinical studies. As such, this review focuses on the background of MSCs and medical research in this area, bridging bench and bedside applications. Conflicting preclinical results and published data from our laboratory are discussed.",
keywords = "Bone marrow, Mesenchymal stem cell",
author = "Lee, {Kuan Der}",
year = "2008",
month = "5",
language = "English",
volume = "31",
pages = "228--236",
journal = "Chang Gung Medical Journal",
issn = "0255-8270",
publisher = "Chang Gung Medical Journal",
number = "3",

}

TY - JOUR

T1 - Applications of mesenchymal stem cells

T2 - An updated review

AU - Lee, Kuan Der

PY - 2008/5

Y1 - 2008/5

N2 - Mesenchymal stem cells (MSCs) can be readily isolated from a number of adult and fetal tissues, and have the capacity of expansion in vitro on a clinical scale. Bone marrow MSCs are able to differentiate into multiple cell lineages that resemble osteoblasts, chondrocytes, myoblasts, adipocytes, endothelial cells, neuron-like cells, cardiomyocytes and hepatocytes. Preclinical findings from animal experiments are promising and have shown that human multipotent MSCs may have considerable therapeutic potential in a wide variety of human diseases. Research into the role that MSCs play in the induction of tolerance in bone marrow and organ transplantation holds great for future therapeutic strategies. Clinical trials are underway to assess the safety, feasibility and efficacy of MSC transplantation in a variety of human diseases. Clinicians need to know the recent progress and rationale for performing these clinical studies. As such, this review focuses on the background of MSCs and medical research in this area, bridging bench and bedside applications. Conflicting preclinical results and published data from our laboratory are discussed.

AB - Mesenchymal stem cells (MSCs) can be readily isolated from a number of adult and fetal tissues, and have the capacity of expansion in vitro on a clinical scale. Bone marrow MSCs are able to differentiate into multiple cell lineages that resemble osteoblasts, chondrocytes, myoblasts, adipocytes, endothelial cells, neuron-like cells, cardiomyocytes and hepatocytes. Preclinical findings from animal experiments are promising and have shown that human multipotent MSCs may have considerable therapeutic potential in a wide variety of human diseases. Research into the role that MSCs play in the induction of tolerance in bone marrow and organ transplantation holds great for future therapeutic strategies. Clinical trials are underway to assess the safety, feasibility and efficacy of MSC transplantation in a variety of human diseases. Clinicians need to know the recent progress and rationale for performing these clinical studies. As such, this review focuses on the background of MSCs and medical research in this area, bridging bench and bedside applications. Conflicting preclinical results and published data from our laboratory are discussed.

KW - Bone marrow

KW - Mesenchymal stem cell

UR - http://www.scopus.com/inward/record.url?scp=45249103524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45249103524&partnerID=8YFLogxK

M3 - Review article

VL - 31

SP - 228

EP - 236

JO - Chang Gung Medical Journal

JF - Chang Gung Medical Journal

SN - 0255-8270

IS - 3

ER -