Application of bioaffinity technology in therapeutic extracorporeal plasmapheresis and large-scale fractionation of human plasma

T. Burnouf, H. Goubran, M. Radosevich

Research output: Contribution to journalReview article

22 Citations (Scopus)


This paper describes the increasingly unique and powerful role that affinity chromatography is occupying both as a tool for the treatment of extracorporeal plasma exchange (to discard biological compounds with noxious metabolic or immunologic effects in patients) and as a purification tool in the production of therapeutic plasma protein derivatives. Management of both applications requires careful monitoring of the parameters applied to the plasma material, to avoid immunological stimulation or activation of the coagulation cascade. Examples of direct current applications of affinity ligands in therapeutic removal and industrial production of plasma compounds are presented. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)65-80
Number of pages16
JournalJournal of Chromatography B: Biomedical Applications
Issue number1
Publication statusPublished - Sep 11 1998
Externally publishedYes



  • Plasma fractionation
  • Plasmapheresis
  • Proteins
  • Reviews

ASJC Scopus subject areas

  • Chemistry(all)

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