Application of bioaffinity technology in therapeutic extracorporeal plasmapheresis and large-scale fractionation of human plasma

T. Burnouf, H. Goubran, M. Radosevich

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

This paper describes the increasingly unique and powerful role that affinity chromatography is occupying both as a tool for the treatment of extracorporeal plasma exchange (to discard biological compounds with noxious metabolic or immunologic effects in patients) and as a purification tool in the production of therapeutic plasma protein derivatives. Management of both applications requires careful monitoring of the parameters applied to the plasma material, to avoid immunological stimulation or activation of the coagulation cascade. Examples of direct current applications of affinity ligands in therapeutic removal and industrial production of plasma compounds are presented. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)65-80
Number of pages16
JournalJournal of Chromatography B: Biomedical Applications
Volume715
Issue number1
DOIs
Publication statusPublished - Sep 11 1998
Externally publishedYes

Fingerprint

Plasma (human)
Fractionation
Plasmas
Affinity chromatography
Coagulation
Purification
Blood Proteins
Chemical activation
Ligands
Derivatives
Monitoring

Keywords

  • Plasma fractionation
  • Plasmapheresis
  • Proteins
  • Reviews

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Application of bioaffinity technology in therapeutic extracorporeal plasmapheresis and large-scale fractionation of human plasma. / Burnouf, T.; Goubran, H.; Radosevich, M.

In: Journal of Chromatography B: Biomedical Applications, Vol. 715, No. 1, 11.09.1998, p. 65-80.

Research output: Contribution to journalReview article

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