This paper describes the increasingly unique and powerful role that affinity chromatography is occupying both as a tool for the treatment of extracorporeal plasma exchange (to discard biological compounds with noxious metabolic or immunologic effects in patients) and as a purification tool in the production of therapeutic plasma protein derivatives. Management of both applications requires careful monitoring of the parameters applied to the plasma material, to avoid immunological stimulation or activation of the coagulation cascade. Examples of direct current applications of affinity ligands in therapeutic removal and industrial production of plasma compounds are presented. Copyright (C) 1998 Elsevier Science B.V.
|Number of pages||16|
|Journal||Journal of Chromatography B: Biomedical Applications|
|Publication status||Published - Sep 11 1998|
- Plasma fractionation
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