Application of Aluminum Nitride Thin Film on Biosensing of Cell Differentiation

Keng Liang Ou, Chang Chih Chen, Che Tong Lin, Chin Sung Chen, Chia Cheng Lin, Sheng Yang Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The microstructural properties and functional failure of Al-N thin films metal-insulator-metal (MIM) capacitors fabricated by reactive-sputtering were studied for the application as differential biosensing of bone cell. The film properties and capacitor capability of Al-N films with and without cell culture were determined using glancing incident X-ray diffraction, leakage current density, cross-sectional transmission electron microscopy, and stress analysis as well as biocompatibility test. The as-deposited Al film has a face-center cubic structure and a low resistivity of 3.21 μ cm. With increasing nitrogen concentration of Al-N films, phase transformations are identified as fcc-Al→fcc-Al (N) →fcc-AlN→hcp-AlN. As the testing result of MIM capacitor, it was shown that the failure of the AlN MIM capacitors was caused by microvoids formed on the film after cell culture. The microvoid having occurred at the cell/AlN MIM capacitor caused it to leak out much of the current to the extent of a few microamperes even at 150 kVcm. The formation of microvoid and low break down voltage were explained by the stress variation during the cell differentiation and proliferation. The stress induced by interaction bone cell and hcp-AlN film resulted in lattice and/or atomic displacement and distortion of AlN. It is believed that the [002] oriented AlN film is shown to perform effectively as a biosensing film to detect the cell differentiation and proliferation by MIM capacitor device. Furthermore, the biosensing film will have a potential for use in wireless technology to monitor the osseointegration in the future.

Original languageEnglish
JournalJournal of the Electrochemical Society
Volume154
Issue number2
DOIs
Publication statusPublished - 2007
Externally publishedYes

Fingerprint

Aluminum nitride
aluminum nitrides
Metals
Thin films
thin films
cells
capacitors
Capacitors
metals
insulators
Cell culture
bones
Bone
aluminum nitride
stress analysis
Reactive sputtering
biocompatibility
Electric breakdown
Stress analysis
Biocompatibility

ASJC Scopus subject areas

  • Electrochemistry
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Cite this

Application of Aluminum Nitride Thin Film on Biosensing of Cell Differentiation. / Ou, Keng Liang; Chen, Chang Chih; Lin, Che Tong; Chen, Chin Sung; Lin, Chia Cheng; Lee, Sheng Yang.

In: Journal of the Electrochemical Society, Vol. 154, No. 2, 2007.

Research output: Contribution to journalArticle

Ou, Keng Liang ; Chen, Chang Chih ; Lin, Che Tong ; Chen, Chin Sung ; Lin, Chia Cheng ; Lee, Sheng Yang. / Application of Aluminum Nitride Thin Film on Biosensing of Cell Differentiation. In: Journal of the Electrochemical Society. 2007 ; Vol. 154, No. 2.
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