Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression: Detected by terminal-deoxynucleotidyl-transferase- mediated dUTP-FITC nick end labelling (TUNEL)

H. J. Harn, K. L. Shen, K. C. Yueh, L. I. Ho, J. C. Yu, S. C. Chiu, W. H. Lee

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Aims: We examined the relationship between apoptosis and three different major stages of human breast carcinoma: intraductal carcinoma (DCIS), infiltrating duct carcinoma (IDC) and metastatic carcinoma in lymph nodes. We also determined the correlation between apoptosis and oestrogen receptor (ER), progesterone receptor (PR) and p53. Methods and results: The study investigates the extent of apoptosis in 63 breast carcinomas by in-situ endlabelling, in formalin-fixed, paraffin-processed tissue sections. The 63 breast carcinomas, included 22 DCISs, 26 IDCs, three infiltrating lobular carcinomas (ILC) and 12 metastatic lymph nodes. The apoptotic labelling index was higher in DCIS than IDC and metastatic carcinoma (P

Original languageEnglish
Pages (from-to)534-539
Number of pages6
JournalHistopathology
Volume31
Issue number6
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Apoptosis
  • Oestrogen receptor
  • p53
  • Progesterone receptor
  • TUNEL

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

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