Apoptosis induced by nucleosides in the human hepatoma HepG2

Suh-Ching Yang, Che Lin Chiu, Chi Chang Huang, Jiun-Rong Chen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: To investigate the apoptotic effects of nucleosides on the human hepatoma HepG2. Methods: The nucleosides included inosine (I), cytidine (C), uridine (U), thymidine (T), adenosine (A), and guanosine (G). Cells were incubated by the mediums with or without nucleosides at 37 °C in a 50 mL/L CO2 humidified atmosphere. Results: It was found that the cell viabilities were significantly decreased, when cells were treated with 30 mmol/L I, 30 mmol/L C, 30 mmol/L U, 30 mmol/L T, 0.5 mmol/L A, and 0.5 mmol/L G after 12 h incubation (P1, cells were significantly increased in the mediums containing nucleosides such as C, U, T, A, and G (P

Original languageEnglish
Pages (from-to)6381-6384
Number of pages4
JournalWorld Journal of Gastroenterology
Volume11
Issue number40
Publication statusPublished - Oct 28 2005

Keywords

  • Apoptosis
  • HepG2
  • Nucleoside

ASJC Scopus subject areas

  • Gastroenterology

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