Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage

H. J. Harn, H. F. Hsieh, L. I. Ho, C. P. Yu, J. H. Chen, C. C. Chiu, H. C. Fan, W. H. Lee

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18 Citations (Scopus)

Abstract

Aims: We investigated the significance of apoptosis, using the terminal deoxynucleotidyl transferase mediated dUTP-digoxigenin nick end-labelling method, in nasopharyngeal carcinoma biopsy samples. Methods and results: The apoptotic index (AI) in 50 nasopharyngeal carcinomas was compared with various histopathological features and clinical stage. Also, the AI was correlated with p53, bcl-2 and Ki67 expression by immunohistochemistry. In histopathological studies, the AI was significantly higher in mixed cellular type (MC) than in keratizing squamous cell type (KS) and spindle cell type (SC) (P

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalHistopathology
Volume33
Issue number2
DOIs
Publication statusPublished - 1998
Externally publishedYes

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Keywords

  • Apoptosis
  • bcl-2
  • Ki67
  • Nasopharyngeal carcinoma
  • p53

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

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