Abstract

The apolipoprotein E-ε4 allele is a well-known genetic risk factor for late-onset Alzheimer's disease, which also impacts the cognitive functions and brain network connectivity in healthy middle-aged adults without dementia. Previous studies mainly focused on the effects of apolipoprotein E-ε4 allele on single index using task or resting-state fMRI. However, how these evoked and spontaneous BOLD indices interact with each other remains largely unknown. Therefore, we evaluated the 'rest-stimulus interaction' between working-memory activation and resting-state connectivity in middle-aged apolipoprotein E-ε4 carriers (n=9) and non-carriers (n=8). Four n-back task scans (n = 0, 1, 2, 3) and one resting-state scan were acquired at a 3T clinical MRI scanner. The working-memory beta maps of low-, moderate-, and high-memory loads and resting-state connectivity maps of default mode, executive control, and hippocampal networks were derived and compared between groups. Apolipoprotein E-ε4 carriers presented declined working-memory activation in the high-memory load across whole brain regions and reduced hippocampal connectivity compared with non-carriers. In addition, disrupted rest-stimulus interactions were found in the right anterior insula and bilateral parahippocampal regions for middle-aged adults with apolipoprotein E-ε4 allele. The rest-stimulus interaction improved the detectability of network integrity changes in apolipoprotein E-ε4 carriers, demonstrating the disrupted intrinsic connectivity within the executive-functional regions and the modulated memory-encoding capability within hippocampus-related regions.

Original languageEnglish
Article numbere0128442
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 8 2015

Fingerprint

middle-aged adults
Apolipoprotein E4
apolipoprotein E
Alleles
alleles
Data storage equipment
Short-Term Memory
Brain
Chemical activation
brain
dementia
Executive Function
scanners
Alzheimer disease
hippocampus
cognition
Magnetic resonance imaging
Cognition
Dementia
Hippocampus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

APOE-ε4 allele altered the rest-stimulus interactions in healthy middle-aged adults. / Yan, Feng Xian; Wu, Chang-Wei; Chao, Yi Ping; Chen, Chi Jen; Tseng, Ying Chi.

In: PLoS One, Vol. 10, No. 6, e0128442, 08.06.2015.

Research output: Contribution to journalArticle

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