APCcdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division

Alexandra Reis, Heng Yu Chang, Mark Levasseur, Keith T. Jones

Research output: Contribution to journalArticlepeer-review

114 Citations (Scopus)

Abstract

Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

Original languageEnglish
Pages (from-to)539-540
Number of pages2
JournalNature Cell Biology
Volume8
Issue number5
DOIs
Publication statusPublished - May 2006
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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