APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division.

Alexandra Reis, Heng Yu Chang, Mark Levasseur, Keith T. Jones

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

Original languageEnglish
Pages (from-to)539-540
Number of pages2
JournalNature cell biology.
Volume8
Issue number5
Publication statusPublished - May 2006
Externally publishedYes

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Oocytes
Anaphase-Promoting Complex-Cyclosome
Meiotic Prophase I
Prophase
G1 Phase
Luteinizing Hormone
Ovary
Cell Cycle

ASJC Scopus subject areas

  • Cell Biology

Cite this

Reis, A., Chang, H. Y., Levasseur, M., & Jones, K. T. (2006). APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division. Nature cell biology., 8(5), 539-540.

APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division. / Reis, Alexandra; Chang, Heng Yu; Levasseur, Mark; Jones, Keith T.

In: Nature cell biology., Vol. 8, No. 5, 05.2006, p. 539-540.

Research output: Contribution to journalArticle

Reis, A, Chang, HY, Levasseur, M & Jones, KT 2006, 'APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division.', Nature cell biology., vol. 8, no. 5, pp. 539-540.
Reis, Alexandra ; Chang, Heng Yu ; Levasseur, Mark ; Jones, Keith T. / APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division. In: Nature cell biology. 2006 ; Vol. 8, No. 5. pp. 539-540.
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