Abstract

Background: Impairment of arterial properties has been suggested as a pathological link between diabetes and adverse cardiovascular (CV) events. Accumulating evidence has supported a role for reduced nocturnal blood pressure (BP) reduction in predicting CV risk. In light of the clinical importance of CV risk in diabetic patients, the question of whether normotensive Type 2 diabetic patients have increased CV risk as determined by augmentation index (AI) value deserves further attention. The association between AI value and the magnitude of nocturnal BP reduction is also of interest. Purpose: This study aimed to compare AI between normotensive Type 2 diabetic patients and mildly hypertensive patients. The association between AI and the magnitude of nocturnal BP reduction in Type 2 diabetic patients was also examined. Methods: A total of 113 participants were included in this study. AI was derived by pulse wave analysis using radial applanation tonometry coupled with the generalized transfer function. Ambulatory BP measurements were performed over a 24-hour period. Results: There was no significant difference in AI between the diabetic patients and the mildly hypertensive patients after adjustment of age and body height. On the other hand, the diabetic patients exhibited a significantly lesser degree of nocturnal BP reduction than the mildly hypertensive patients even after adjusting conventional CV risk. AI was not correlated to the magnitude of nocturnal BP reduction in the diabetic patients. Conclusions: The diabetic patients did not have higher AI than mild hypertensive patients, whereas the diabetic patients had significant blunted nocturnal BP reduction than the mildly hypertensive patients. The utility of AI as a maker for CV risk in normotensive Type 2 diabetic patients remained to be determined.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume3
Issue number2
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Type 2 Diabetes Mellitus
Blood Pressure
Pulse Wave Analysis
Body Height
Manometry

Keywords

  • Augmentation index
  • Nocturnal BP reduction
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{d45926756ea9441883d66efb367fba1d,
title = "Aortic Augmentation Index is not a Useful Index of Cardiovascular Risk in Type 2 Diabetes",
abstract = "Background: Impairment of arterial properties has been suggested as a pathological link between diabetes and adverse cardiovascular (CV) events. Accumulating evidence has supported a role for reduced nocturnal blood pressure (BP) reduction in predicting CV risk. In light of the clinical importance of CV risk in diabetic patients, the question of whether normotensive Type 2 diabetic patients have increased CV risk as determined by augmentation index (AI) value deserves further attention. The association between AI value and the magnitude of nocturnal BP reduction is also of interest. Purpose: This study aimed to compare AI between normotensive Type 2 diabetic patients and mildly hypertensive patients. The association between AI and the magnitude of nocturnal BP reduction in Type 2 diabetic patients was also examined. Methods: A total of 113 participants were included in this study. AI was derived by pulse wave analysis using radial applanation tonometry coupled with the generalized transfer function. Ambulatory BP measurements were performed over a 24-hour period. Results: There was no significant difference in AI between the diabetic patients and the mildly hypertensive patients after adjustment of age and body height. On the other hand, the diabetic patients exhibited a significantly lesser degree of nocturnal BP reduction than the mildly hypertensive patients even after adjusting conventional CV risk. AI was not correlated to the magnitude of nocturnal BP reduction in the diabetic patients. Conclusions: The diabetic patients did not have higher AI than mild hypertensive patients, whereas the diabetic patients had significant blunted nocturnal BP reduction than the mildly hypertensive patients. The utility of AI as a maker for CV risk in normotensive Type 2 diabetic patients remained to be determined.",
keywords = "Augmentation index, Nocturnal BP reduction, Type 2 diabetes",
author = "Wang, {Mei Yeh} and Chang, {Nei Chung} and Liu, {Ju Chi} and Tsai, {Pei Shan}",
year = "2011",
month = "4",
doi = "10.1016/j.jecm.2011.02.002",
language = "English",
volume = "3",
pages = "70--73",
journal = "Journal of Experimental and Clinical Medicine",
issn = "1878-3317",
publisher = "Elsevier Taiwan LLC",
number = "2",

}

TY - JOUR

T1 - Aortic Augmentation Index is not a Useful Index of Cardiovascular Risk in Type 2 Diabetes

AU - Wang, Mei Yeh

AU - Chang, Nei Chung

AU - Liu, Ju Chi

AU - Tsai, Pei Shan

PY - 2011/4

Y1 - 2011/4

N2 - Background: Impairment of arterial properties has been suggested as a pathological link between diabetes and adverse cardiovascular (CV) events. Accumulating evidence has supported a role for reduced nocturnal blood pressure (BP) reduction in predicting CV risk. In light of the clinical importance of CV risk in diabetic patients, the question of whether normotensive Type 2 diabetic patients have increased CV risk as determined by augmentation index (AI) value deserves further attention. The association between AI value and the magnitude of nocturnal BP reduction is also of interest. Purpose: This study aimed to compare AI between normotensive Type 2 diabetic patients and mildly hypertensive patients. The association between AI and the magnitude of nocturnal BP reduction in Type 2 diabetic patients was also examined. Methods: A total of 113 participants were included in this study. AI was derived by pulse wave analysis using radial applanation tonometry coupled with the generalized transfer function. Ambulatory BP measurements were performed over a 24-hour period. Results: There was no significant difference in AI between the diabetic patients and the mildly hypertensive patients after adjustment of age and body height. On the other hand, the diabetic patients exhibited a significantly lesser degree of nocturnal BP reduction than the mildly hypertensive patients even after adjusting conventional CV risk. AI was not correlated to the magnitude of nocturnal BP reduction in the diabetic patients. Conclusions: The diabetic patients did not have higher AI than mild hypertensive patients, whereas the diabetic patients had significant blunted nocturnal BP reduction than the mildly hypertensive patients. The utility of AI as a maker for CV risk in normotensive Type 2 diabetic patients remained to be determined.

AB - Background: Impairment of arterial properties has been suggested as a pathological link between diabetes and adverse cardiovascular (CV) events. Accumulating evidence has supported a role for reduced nocturnal blood pressure (BP) reduction in predicting CV risk. In light of the clinical importance of CV risk in diabetic patients, the question of whether normotensive Type 2 diabetic patients have increased CV risk as determined by augmentation index (AI) value deserves further attention. The association between AI value and the magnitude of nocturnal BP reduction is also of interest. Purpose: This study aimed to compare AI between normotensive Type 2 diabetic patients and mildly hypertensive patients. The association between AI and the magnitude of nocturnal BP reduction in Type 2 diabetic patients was also examined. Methods: A total of 113 participants were included in this study. AI was derived by pulse wave analysis using radial applanation tonometry coupled with the generalized transfer function. Ambulatory BP measurements were performed over a 24-hour period. Results: There was no significant difference in AI between the diabetic patients and the mildly hypertensive patients after adjustment of age and body height. On the other hand, the diabetic patients exhibited a significantly lesser degree of nocturnal BP reduction than the mildly hypertensive patients even after adjusting conventional CV risk. AI was not correlated to the magnitude of nocturnal BP reduction in the diabetic patients. Conclusions: The diabetic patients did not have higher AI than mild hypertensive patients, whereas the diabetic patients had significant blunted nocturnal BP reduction than the mildly hypertensive patients. The utility of AI as a maker for CV risk in normotensive Type 2 diabetic patients remained to be determined.

KW - Augmentation index

KW - Nocturnal BP reduction

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=79954851361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954851361&partnerID=8YFLogxK

U2 - 10.1016/j.jecm.2011.02.002

DO - 10.1016/j.jecm.2011.02.002

M3 - Article

AN - SCOPUS:79954851361

VL - 3

SP - 70

EP - 73

JO - Journal of Experimental and Clinical Medicine

JF - Journal of Experimental and Clinical Medicine

SN - 1878-3317

IS - 2

ER -